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Air-stable magnesium nickel hydride with autocatalytic and self-protective effect for reversible hydrogen storage

Nano Research 2022年第3期15卷 2130-2137页

作者： Zhongliang Ma Yingyan Zhao Zhaohui Wu Qinke Tang Jinlian Ni Yunfeng Zhu Jiguang Zhang Yana Liu Yao Zhang Hai-Wen Li Xiaohui Hu Xinjian Zhu Liquan Li College of Materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech University30 South Puzhu RoadNanjing 211816China Jiangsu Qianjing New Energy Industrial Technology Research Institute Co. Ltd1 Dangui RoadZhenjiang 212028China School of Materials Science and Engineering Southeast UniversityNanjing 211189China Hefei General Machinery Research Institute Hefei230031China WPI International Institute for Carbon-Neutral Energy Research(WPI-I2CNER)Kyushu UniversityFukuoka 819-0395Japan

Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key *** this work,a novel method,namely hydriding combustion synthesis plus short-term mechanical milling followed by air exposure,was proposed to synthesize air stable and autocatalytic magnesium nickel hydride(Mg2NiH4),which shows excellent hydrogen absorption/desorption kinetics,capacity retention and oxidation *** short-term-milled Mg2NiH4 can desorb 2.97 wt.%hydrogen within 500 s at 230℃.Even after exposure under air atmosphere for 67 days,it can still desorb 2.88 wt.%hydrogen within 500 s at 230℃.The experimental and theoretical results both indicated that the surface of as-milled Mg2NiH4 was easy to be oxidized under air ***,the in-situ formed Ni during air exposure of Mg2NiH4 improved the hydrogen desorption kinetics,and the formed surface passivation layer maintained the hydrogen storage capacity and avoided further poisoning,which we called autocatalytic and self-protective *** a novel dual effect modified the reaction activity and oxidation resistance of the air-exposed *** findings provide useful insights into the design and preparation of air stable metal-based hydride for large-scale utilization and long-term storage.

关键词： oxidation resistance autocatalytic self-protective magnesium based hydride hydrogen storage

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Biointerface engineering of self-protective bionic nanomissiles for targeted synergistic chemotherapy

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Chinese Chemical Letters 2023年第4期34卷 116-121页

作者： Xueyan Zhen Linhao Li Lanlan Jia Aihong Zhu Yixuan Yang Sicen Wang Xiaoyu Xie School of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi’an 710061China Shaanxi Engineering Research Center of Cardiovascular Drugs Screening&Analysis Xi’an 710061China

Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor ***, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.

关键词： Aptamer self-protective Biointerface Targeted drug delivery Synergistic chemotherapy

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