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Neurological Disorder

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China Medical Abstracts(Internal Medicine) 2011年第4期28卷 242-242页

给予颞叶癫痫患者电刺激以评估癫痫的发作位点及发作的过渡时间

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 18-18页

作者： Kalitzin S. Velis D. Suffczynski P. 江山 Medical Physics Department Dutch Epilepsy Clinics FoundationAchterweg 5 2103 SW Heemstede Netherlands

Objective: To explore and validate a novel stimulation and analysis paradigm p roposed to monitor spatial distribution and temporal changes of the excitability state in patients with temporal lobe epilepsy (TLE). Methods: We use intermitte nt pulse stimulation in the frequency range 10-20 Hz. A quantitative measure of spectral phase de-modulation, the relative phase clustering index (rPCI) was a pplied to the evoked EEG signals,measured from electrodes implanted in the hippo campal formation.Results: We found that in the interictal periods, high values o f rPCI recorded from specific sites were correlated with the most probable seizu re onset sites (SOS). Furthermore we found that high values of rPCI from certain locations correlated with shorter time intervals to the next seizure. Conclusio ns:Our clinical findings indicate that although the precise moment of ictal tran sitions is in general unpredictable, it maybe possible to estimate the probabili ty of occurrence of some epileptic seizures. Significance: The use of the rPCI f or probabilistic forecasting of upcoming epileptic seizures is warranted.rPCI me asurements may be used to guide interventions with the aim of modifying local ti ssue excitability that ultimately might prevent ictal transitions.

关键词：颞叶癫痫患者过渡时间电刺激 seizures epileptic 发作间期海马结构 epilepsy stimulation evoked

难治性癫痫患者的神经精神性卟啉症:3例病例报道

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 24-24页

作者： Winkler A.S. Peters T.J. Elwes R.D.C. 胡慧敏 Dept. of Clinical Biochemistry King's College HospitalDenmark Hill London SE5 9RS United Kingdom Prof.

Objectives: Although epileptic seizures are an infrequent feature of acute att acks of the neuropsychiatric porphyrias, there are no significant reports of por phyria in chronic epilepsy. This paper attempts to redress the balance. Methods: Three case reports,including detailed laboratory and molecular diagnostics.Resu lts: Two patients with variegate porphyria and one with acute intermittent porph yria, referred within 1 year to a specialist porphyria service, with a long hist ory of chronic refractory epileptic seizures, are described. Conclusions: Porphy ria maybe an aetiological factor in some cases of chronic refractory partial or generalised epilepsy. Porphyria should also be considered if addition of a new a nti-epileptic medication causes a major deterioration in the epilepsy.

关键词：难治性癫痫神经精神性卟啉症 epileptic epilepsy 癫痫病 seizures refractory 变异型 medication