给予颞叶癫痫患者电刺激以评估癫痫的发作位点及发作的过渡时间

作     者：Kalitzin S. Velis D. Suffczynski P. 江山 

作者机构：Medical Physics Department Dutch Epilepsy Clinics FoundationAchterweg 5 2103 SW Heemstede Netherlands 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第7期

页      面：18-18页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：颞叶癫痫患者 过渡时间 电刺激 seizures epileptic 发作间期 海马结构 epilepsy stimulation evoked 

摘      要：Objective: To explore and validate a novel stimulation and analysis paradigm p roposed to monitor spatial distribution and temporal changes of the excitability state in patients with temporal lobe epilepsy (TLE). Methods: We use intermitte nt pulse stimulation in the frequency range 10-20 Hz. A quantitative measure of spectral phase de-modulation, the relative phase clustering index (rPCI) was a pplied to the evoked EEG signals,measured from electrodes implanted in the hippo campal ***: We found that in the interictal periods, high values o f rPCI recorded from specific sites were correlated with the most probable seizu re onset sites (SOS). Furthermore we found that high values of rPCI from certain locations correlated with shorter time intervals to the next seizure. Conclusio ns:Our clinical findings indicate that although the precise moment of ictal tran sitions is in general unpredictable, it maybe possible to estimate the probabili ty of occurrence of some epileptic seizures. Significance: The use of the rPCI f or probabilistic forecasting of upcoming epileptic seizures is *** me asurements may be used to guide interventions with the aim of modifying local ti ssue excitability that ultimately might prevent ictal transitions.