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risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in Shanghai patients with arthropathy

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Acta Pharmacologica Sinica 2004年第3期25卷 103-111页

作者： Wen SHI2,Yong-ming WANG,Shao-li LI3,Min YAN3,Duan Li,Bin-yan CHEN,Neng-neng CHENG Department of Pharmacology,School of Pharmacy,Fudan University,Shanghai 200032 The Center for Drug Reevaluation and 3 The Center for Adverse Drug Reaction Monitoring,State Food and Drug Administration,Beijing 100061,China Department of Pharmacology School of Pharmacy Fudan University 上海 200032 The Center for Drug Reevaluation and The Center for Adverse Drug Reaction Monitoring State Food and Drug Administration 北京 100061

AIM: The study was to screen the possible risk factors of adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs) in Shanghai patients with arthropathy. METHODS: The subjects were ran- domly selected from a database of outpatients with arthropathy from 9 main hospitals in Shanghai. A door to door retrospective epidemiological survey was used to collect demographic information about the patients, both indi- vidual and familial. This included data on their medical histories, lifestyle and dietary habits, history of smoking and alcohol consumption, history of drug therapy, quality of life (QOL) prior to NSAIDs intake, history of NSAIDs therapy and its ADR events, etc. Descriptive statistical methods and univariate analysis were also used to identify possible risk factors for ADRs induced by NSAIDs. RESULTS: Of the 1002 patients surveyed, the average length of NSAIDs intake was 2 years. ADR incidence from different NSAIDs was high, in a range from 46.7 %-66.2 %. In general, the candidate risk factors for ADRs were different for each NSAID. Each of the candidate risk factors were defined and studied in order to evaluate its role in the determination of ADRs from NSAIDs. “Family history of ADRs caused by NSAIDs” was found to be a significant risk factor for the four commonly used NSAIDs: meloxicam, diclofenac, nimesulide, and nabumetone. CONCLUSION: A retrospective epidemiological survey was useful in detecting the risk factors for ADRs caused by NSAIDs. The study found that different NSAIDs might have different risk factors and that there is no single risk factor universally applicable to all NSAIDs.

关键词： non-steroidal anti-inflammatory drugs adverse drug reaction risk factors retrospective studies quality of life

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risk factors of prognosis after acute kidney injury in hospitalized patients

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Frontiers of Medicine 2017年第3期11卷 393-402页

作者： Sasa Nie Zhe Feng Lihua Xia Jiuxu Bai Fenglin Xiao Jian Liu Li Tang Xiangmei Chen Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing 100853 China

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury （AK1） remain unclear. We conducted a retrospective survey of Chinese People＇s Liberation Army General Hospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by Kidney Disease Improving Global Outcomes. The epidemiological features and factors influencing hospital mortality and renal function recovery were evaluated through logistic regression analysis. Among 77 662 cases of hospitalized patients, 1387 suffered from AKI. The incidence rate and mortality of AKI were 1.79~ and 14.56%, respectively. Multivariate logistic regression analysis revealed that high AKI stage, age greater than 80 years, neoplastic disease, low cardiac output, increased white blood cell count, and decreased platelet count and serum albumin levels were the risk factors affecting the mortality of AKI patients. Conversely, body mass index between 28 and 34.9 was a protective factor. Increased AKI stage, tumor disease, post-cardiopulmonary resuscitation, and RRT were the risk factors of renal function recovery upon discharge. In addition to traditional risk factors, white blood cell count, platelet count, albumin, and BMI were the predictors of the mortality of AKI patients. No laboratory indicators were found to be the risk factors of renal function recovery in AKI patients.

关键词： acute kidney injury risk factors prognosis

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risk factors for immediate post-operative fatal recurrence after curative resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第1期12卷 99-104页

作者： Bong-Wan Kim Young-Bae Kim Hee-Jung Wang Myung-Wook Kim Department of Surgery Ajou University School of MedicineWonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea Department of Pathology Ajou University School of Medicine.Wonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea

AIM： To investigate the clinicopathological risk factors for immediate post-operative fatal recurrence of hepatocellular carcinoma （HCC）, which may have practical implication and contribute to establishing high risk patients for pre- or post-operative preventive measures against HCC recurrence. METHODS： From June 1994 to May 2004, 269 patients who received curative resection for HCC were reviewed. Of these patients, those who demonstrated diffuse intrahepatic or multiple systemic recurrent lesions within 6 mo after surgery were investigated （fatal recurrence group）. The remaining patients were designated as the control group, and the two groups were compared for clinicopathologic risk factors. RESULTS： Among the 269 patients reviewed, 30 patients were enrolled in the fatal recurrence group. Among the latter, 20 patients showed diffuse intrahepatic recurrence type and 10 showed multiple systemic recurrence type. Multivariate analysis between the fatal recurrence group and control group showed that preoperative serum alpha-fetoprotein （AFP） level was greater than 1 000 μg/L （P= 0.02; odds ratio = 2.98）, tumor size greater than 6.5 cm （P= 0.03; OR= 2.98）, and presence of microvascular invasion （P= 0.01; OR=4.89） were the risk factors in the fatal recurrence group. The 48.1% of the patients who had all the three risk factors and the 220 of those who had two risk factors experienced fatal recurrence within 6 mo after surgery. CONCLUSION： Three distinct risk factors for immediate post-operative fatal recurrence of HCC after curative resection are pre-operative serum AFP level 〉 1 000 μg/L,tumor size〉6.5 cm, and microvascular invasion. The high risk patients with two or more risk factors should be the candidates for various adjuvant clinical trials.

关键词： Hepatocellular carcinoma Hepatectomy Early recurrence risk factors

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risk factors for delayed hemorrhage after endoscopic sphincterotomy

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 467-472页

作者： Jing Yan Chun-Xia Zhou Chong Wang Yuan-Yuan Li Le-Ying Yang You-Xiang Chen Jian-Jian Hu Guo-Hua Li Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Urology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Background:Hemorrhage is one of the most serious complications of endoscopic sphincterotomy(EST).The risk factors for delayed hemorrhage are not *** study aimed to explore the risk factors for post-EST delayed hemorrhage and suggest some precautionary ***:This study analyzed 8477 patients who successfully underwent endoscopic retrograde cholangiopancreatography(ERCP)and EST between January 2007 and June 2015 in the First Affiliated Hospital of Nanchang *** and multivariate analyses were performed to find the risk factors for delayed hemorrhage after ***:Of the 8477 patients screened,137(1.62%)experienced delayed *** analysis showed that male,the severity of jaundice,duodenal papillary adenoma and carcinoma,diabetes,intraoperative bleeding,moderate and large incisions,and directional deviation of incision were risk factors for post-EST delayed hemorrhage(Prisk factors for post-EST delayed ***:Delayed hemorrhage is the most common and dangerous complication of *** bleeding and directional deviation of incision are independent risk factors for post-EST delayed hemorrhage.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangiopancreatography Hemorrhage risk factors

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risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model

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Military Medical Research 2022年第4期9卷 444-483页

作者： Stefan Sammito Vedran Hadzic Thomas Karakolis Karen R.Kelly Susan P.Proctor Ainars Stepens Graham White Wes O.Zimmermann Section Experimental Aerospace Medicine Research German Air Force Centre of Aerospace MedicineFlughafenstraBe 151147 CologneGermany Occupational Medicine Faculty of MedicineOtto-Von-Guericke-University of Magdeburg39120 MagdeburgGermany Faculty of Sport University of Ljubljana1000 LjubljanaSlovenia Defence Research and Development Canada TorontoON M3K 2C9Canada Warfighter Performance Naval Health Research CenterSan DiegoCA 921063599USA Military Performance Division US Army Research Institute of Environmental MedicineNatickMA 01760USA Research Service VA Boston Healthcare SystemBostonMA 02130USA Centre for Military Medicine Research Riga Stradins UniversityRiga 1007Latvia Human and Social Sciences Group Defense Science and Technology LaboratoryPortsdown Hill RoadFareham PO176ADUK Department of Military Sports Medicine Royal Netherlands Army3584 AB UtrechtThe Netherlands Department of Military/Emergency Medicine Uniformed Services University of the Health SciencesBethesdaMD 20814USA.

Background: Musculoskeletal injuries(MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during initial training,operational training, and deployment and have a direct negative impact on overall troop readiness. Currently, a systematic overview of all risk factors for MSkIs in the military is not ***: A systematic literature search was carried out using the PubMed, Ovid/Medline, and Web of Science databases from January 1, 2000 to September 10, 2019. Additionally, a reference list scan was performed(using the “snowball method”). Thereafter, an international, multidisciplinary expert panel scored the level of evidence per risk factor, and a classification of modifiable/non-modifiable was ***: In total, 176 original papers and 3 meta-analyses were included in the review. A list of 57 reported potential risk factors was formed. For 21 risk factors, the level of evidence was considered moderate or strong. Based on this literature review and an in-depth analysis, the expert panel developed a model to display the most relevant risk factors identified, introducing the idea of the “order of importance” and including concepts that are modifiable/nonmodifiable, as well as extrinsic/intrinsic risk ***: This is the qualitative systematic review of studies on risk factors for MSkIs in the military that has attempted to be all-inclusive. A total of 57 different potential risk factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups.

关键词： Military Musculoskeletal injuries risk factors Prevention Intervention Injury

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risk factors for neoplastic progression in Barrett's esophagus

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World Journal of Gastroenterology 2011年第32期17卷 3672-3683页

作者： Elizabeth F Wiseman Yeng S Ang Department of Gastroenterology Royal Albert Edward Infirmary Wigan Lane Wigan Greater Manchester WN1 2NN United Kingdom Faculty of Medical and Human Sciences School of Translational Medicine The University of Manchester Oxford Road Manchester M13 9PL United Kingdom

Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.

关键词： Barrett’s esophagus Esophageal adeno-carcinoma Metaplasia-dysplasia-carcinoma Neoplastic progression risk factors

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risk factors of metabolic syndrome after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 582-587页

作者： Jun Zheng Wei-Lin Wang Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalZhejiang University School of Medicine Department of Surgery The University of Hong Kong Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

BACKGROUND： Liver transplantation is a treatment of choice for both acute and chronic liver failure. Accompanied with the increase of long-term survival rates of recipients, metabolic syndrome and its individual components, including obesity, hyperglycemia, hypertension and hyperlipidemia, have become more frequent post liver transplantation. Here we reviewed the literature concerning the risk factors for the development of metabolic complications in liver recipients.

关键词： liver transplantation risk factors hypertension hyperlipidemia diabetes mellitus

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risk factors of Learning Disabilities in Chinese Children in Wuhan

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Biomedical and Environmental Sciences 2003年第4期16卷 392-397页

作者： BIN YAO AND HAN-RONG WUDepartment of Children and Adolescent Health, Maternity and Child Health Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China Department of Children and Adolescent Health Maternity and Child Health Care Tongji Medical College Huazhong University of Science and Technology 湖北 Wuhan 430030

Objective To investigate prevalence rate of learning disabilities (LD) in Chinese children, and to explore related risk factors, and to provide theoretical basis for preventing such disabilities. Methods One thousand and one hundred fifty one children were randomly selected in primary schools. According to criteria set by ICD-10, 118 children diagnosed as LD were classified into the study group. Four hundred and ninety one children were classified into the normal control group. Five hundred and forty two children were classified into the excellent control group. The study instruments included PRS (The pupil rating scale revised screening for learning disabilities), Conners' children behavior check-list taken by parents and YG-WR character check-list. Results The prevalence rate of LD in Chinese children was 10.3%. Significant differences were observed between LD and normally learning children, and between the LD group and the excellent group, in terms of scores of Conners' behavior check-list (Pfactors. Good studying and living environments should be created for LD children.

关键词： Learning disabilities (LD) Behavior problems Character Children risk factors

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risk factors and clinical outcomes of incomplete endoscopic resection of small rectal neuroendocrine tumors in southern China:a 9-year data analysis

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Gastroenterology Report 2023年第1期11卷 191-198页

作者： Xiaoduan Zhuang Shaoheng Zhang Guiquan Chen Zongqi Luo Huiqin Hu Wenfeng Huang Yu Guo Yongwen Ouyang Liang Peng Qing Qing Huiting Chen Bingsheng Li Jie Chen Xinying Wang Department of Gastroenterology Zhujiang HospitalSouthern Medical UniversityGuangzhouP.R.China Department of Gastroenterology Affiliated Dongguan HospitalSouthern Medical University(Dongguan People’s Hospital)DongguanP.R.China Department of Gastroenterology Huizhou First HospitalHuizhouP.R.China Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China Department of Digestive Diseases The First People’s Hospital of FoshanFoshanP.R.China Department of Gastroenterology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouP.R.China Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Gastroenterology and Hepatology Guangzhou Digestive Disease CenterGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouP.R.China Center for Neuroendocrine Tumors Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Head&Neck Tumors and Neuroendocrine Tumors Fudan University Shanghai Cancer CenterShanghaiP.R.China

Background:The histologically complete resection(CR)rate of small rectal neuroendocrine tumors(RNETs)is unsatisfactory at the first *** factors and clinical outcomes associated with incomplete resection(IR)have not been explicitly *** study aims to explore the relevant factors of ***:This retrospective study reviewed patients with small RNETs(10mm)in eight centers from January 2013 to December *** characteristics and clinical outcomes were compared between the CR and IR groups,and the polypectomy and advanced treatment ***:Of the 326 patients included,83(25.5%)were diagnosed with ***(odds ratio[OR]=16.86),a central depression(OR=7.50),and treatment in the early period(OR=2.60)were closely associated with *** analysis revealed that an atypical hyperemic appearance(OR=7.49)and treatment in the early period(OR=2.54)were significantly associated with the inappropriate use of polypectomy(both Prisk factors for ***,an atypical hyperemic appearance and treatment in the early period were significant predisposing factors for inappropriate choice of *** histologically incompletely resected small RNETs,follow-up may be a safe and feasible alternative to rigorous salvage therapy.

关键词： rectal neuroendocrine tumors incomplete resection risk factors clinical outcomes

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risk factors of Precancerous Gastric Lesions in A Population at High risk of Gastric Cancer

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Chinese Journal of Cancer Research 2010年第4期22卷 267-273页

作者： Jian Liu Li-Ping Sun Yue-Hua Gong Yuan Yuan Cancer Institute The First Affiliated Hospital China Medical University Shenyang 110001

Objective： In cancer prevention, the targeting of precancerous lesions has been recognized as the most promising method. However, little attention has been paid to the risk factors of precancerous gastric lesions, especially in rural China where there is high prevalence of precancerous gastric lesions. We therefore conducted a cross-sectional study in Liaoning province, China, to investigate the potential risk and protective factors of these precancerous gastric lesions. Methods： A total of 1,179 subjects with high risk of gastric cancer from Zhuanghe County were included in this study. Standard questionnaires were used in collecting epidemiological factors and the data were then analyzed by the unconditional logistic regression model. Results： Smoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects, and the association of smoking or drinking and the precancerous gastric lesions increased in strength with the daily consumption and duration. As the factors such as age, gender, smoking, alcohol were controlled, a multivariable analysis revealed that there was a significant correlation between the deep-fry food intake and the gastric epithelial dysplasia with the odds ratio （OR） of 1.78 [95% confidence interval （CI）： 1.01-3.12]. Garlic eating was shown to confer protection against the development of gastric ulcer （OR=0.55, 95% CI： 0.33-0.92）. Conclusion： Smoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects. Deep-fry food intake might be one of the risk factors for the precancerous gastric lesions and garlic eating was shown to confer protection against the development of gastric ulcer among rural Chinese population.

关键词： risk factors Precancerous gastric lesions High risk of gastric cancer

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