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Zoological Research 2023年第1期44卷 30-42页

作者： Yu Yan Dong Ik Park Anja Horn Mari Golub Christoph W.Turck Proteomics and Biomarkers Max Planck Institute of PsychiatryMunich 80804Germany Ludwig-Maximilians-Universität Chair of Vegetative AnatomyInstitute of AnatomyFaculty of MedicineMunich 80336Germany Department of Environmental Toxicology University of CaliforniaDavisCA 95616USA

Fluoxetine(Prozac^(TM))is the only antidepressant approved by the US Food and Drug Administration(FDA)for the treatment of major depressive disorder(MDD)in *** its considerable efficacy as a selective serotonin reuptake inhibitor,the possible long-term effects of fluoxetine on brain development in children are poorly *** the current study,we aimed to delineate molecular mechanisms and protein biomarkers in the brains of juvenile rhesus macaques(Macaca mulatta)one year after the discontinuation of fluoxetine treatment using proteomic and phosphoproteomic *** identified several differences in protein expression and phosphorylation in the dorsolateral prefrontal cortex(DLPFC)and cingulate cortex(CC)that correlated with impulsivity in animals,suggesting that the GABAergic synapse pathway may be affected by fluoxetine *** in combination with the identified pathways contribute to a better understanding of the mechanisms underlying the chronic effects of fluoxetine after discontinuation in children.

关键词： Major depressive disorder Fluoxetine rhesus monkeys Proteomics GABAergic synapse

F-heparin modified intraocular lenses in rhesus monkeys

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 141-144页

作者： Gui-Qin Wang Han-Qing Gu Jia-Qin Yuan Hui-Min Sun and Yan-Shan Xu Department of Ophthalmology the Naval General Hospital Beijing 100048 China

AIMIn order to improve the biocompatibility of intraocular lenses (IOL), the polymethylmethacrylate (PMMA) IOL was modified with F-heparin.

关键词： intraocular lenses F-heparin surface modification biocompatibility rhesus monkeys

The Effect of Recombinant Human Parathyroid Hormone 1-84 on Binding Antibody Level in Sprague-dawley Rats and rhesus monkeys

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The Effect of Recombinant Human Parathyroid Hormone 1-84 on ...

A more consistent intraluminal rhesus monkey model of ischemic stroke

The 12th Asian Pacific Confederation of Chemical Engineering Congress

作者： Liu Qinghai~a Wu Hao~b Zhang Xiao-Dong~c Qin Ying~a Tao Xin-Yi~a Ma Xing-Yuan~a Wei Dong-Zhi~a Yang Sheng-Li~d Yuan Bo-Jun~e a New World Institute of Biotechnology State Key Laboratory of Bioreactor Engineering East China University of Science and Technology 200237 Shanghai China b Center for Drug Evaluation Shanghai Municipal Food and Drug Administration 200021 Shanghai China c Genter for New Drug Evaluation The Second Military Medical University 200433 Shanghai China d Shanghai Research Genter of Biotechnology Chinese Academy of Sciences 200233 Shanghai China

＜正＞We studied the effect of Recombinant human parathyroid hormone 1-84（rhPTH 1-84）on the immunogenicity in Sprague-Dawley rats and rhesus *** Rats were divided to re- ceive once daily subcutaneous injection of 20... 详细信息

关键词： rhPTH 1-84 immunogenicity binding antibodies sprague-dawley rats rhesus monkeys

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Neural Regeneration Research 2014年第23期9卷 2087-2094页

作者： Bo Zhao Guowei Shang Jian Chen Xiaokun Geng Xin Ye Guoxun Xu Ju Wang Jiasheng Zheng Hongjun Li Fauzia Akbary Shengli Li Jing Lu Feng Ling Xunming Ji Department of Neurosurgery Xuanwu Hospital Capital Medical University Department of Anesthesiology Xuanwu Hospital Capital Medical University Department of Laboratory Animal Science Capital Medical University Radiology Department Beijing Youan Hospital Capital Medical University Wayne State University School of Medicine Center of Stroke Beijing Institute for Brain Disorders

Endovascular surgery is advantageous in experimentally induced ischemic stroke because it causes fewer cranial traumatic lesions than invasive surgery and can closely mimic the pathophysiology in stroke patients. However, the outcomes are highly variable, which limits the accuracy of evaluations of ischemic stroke studies. In this study, eight healthy adult rhesus monkeys were randomized into two groups with four monkeys in each group： middle cerebral artery occlusion at origin segment （M1） and middle cerebral artery occlusion at M2 segment. The blood flow in the middle cerebral artery was blocked completely for 2 hours using the endovascular microcoil placement technique （1 mm × 10 cm）（undetachable）, to establish a model of cerebral ischemia. The microcoil was withdrawn and the middle cerebral artery blood flow was restored. A reversible middle cerebral artery occlusion model was identified by hematoxylin-eosin staining, digital subtraction angiography, magnetic resonance angiography, magnetic resonance imaging, and neurological evaluation. The results showed that the middle cerebral artery occlusion model was successfully established in eight adult healthy rhesus monkeys, and ischemic lesions were apparent in the brain tissue of rhesus monkeys at 24 hours after occlusion. The rhesus monkeys had symptoms of neurological deficits. Compared with the M1 occlusion group, the M2 occlusion group had lower infarction volume and higher neurological scores. These experimental findings indicate that reversible middle cerebral artery occlusion can be produced with the endovascular microcoil technique in rhesus monkeys. The M2 occluded model had less infarction and less neurological impairment, which offers the potential for application in the field of brain injury research.

关键词： nerve regeneration brain injury rhesus monkeys model middle cerebral artery microcoil infarction stroke interventional therapy digital subtraction angiography magnetic resonance image neuroimaging neuroregeneration

A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair

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Neural Regeneration Research 2014年第10期9卷 1041-1046页

作者： Dong Wang Xijun Huang Guo Fu Liqiang Gu Xiaolin Liu Honggang Wang Jun Hu Jianhua Yi Xiaofeng Niu Qingtang Zhu Department of Orthopedics and Microsurgery the First Affiliated Hospital of Sun Yat-Sen University

Current research on bone marrow stem cell transplantation and autologous or xenogenic nerve transplantation for peripheral nerve regeneration has mainly focused on the repair of peripher-al nerve defects in rodents. In this study, we established a standardized experimental model of radial nerve defects in primates and evaluated the effect of repair on peripheral nerve injury. We repaired 2.5-cm lesions in the radial nerve of rhesus monkeys by transplantation of autografts, acellular allografts, or acellular allografts seeded with autologous bone marrow stem cells. Five months after surgery, regenerated nerve tissue was assessed for function, electrophysiology, and histomorphometry. Postoperative functional recovery was evaluated by the wrist-extension test. Compared with the simple autografts, the acellular allografts and allografts seeded with bone marrow stem cells facilitated remarkable recovery of the wrist-extension functions in the rhesus monkeys. This functional improvement was coupled with radial nerve distal axon growth, a higher percentage of neuron survival, increased nerve fiber density and diameter, increased myelin sheath thickness, and increased nerve conduction velocities and peak amplitudes of compound motor action potentials. Furthermore, the quality of nerve regeneration in the bone marrow stem cells-laden allografts group was comparable to that achieved with autografts. The wrist-extension test is a simple behavioral method for objective quantification of peripheral nerve regeneration.

关键词： nerve regeneration peripheral nerve injury rhesus monkeys bone marrow stem cells allogeneic nerve transplantation wrist-extension test electrophysiology neurological function NSFC grant neural regeneration

The default mode network is affected in the early stage of simian immunodeficiency virus infection:a longitudinal study

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Neural Regeneration Research 2023年第7期18卷 1542-1547页

作者： Zhen-Chao Tang Jiao-Jiao Liu Xue-Tong Ding Dan Liu Hong-Wei Qiao Xiao-Jie Huang Hui Zhang Jie Tian Hong-Jun Li Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijingChina Key Laboratory of Big Data-Based Precision Medicine(Beihang University) Ministry of Industry and Information Technology of the People’s Republic of ChinaBeijingChina Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijingChina Beijing Youan Hospital Capital Medical UniversityBeijingChina Renji Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina Institute of Laboratory Animal Sciences Chinese Academy of Medical SciencesBeijingChina

Acquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode *** recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network following acquired immune deficiency syndrome infection and antiretroviral ***,when brain imaging data at only one time point are analyzed,determining the duration at which the default mode network is the most effective following antiretroviral therapy after the occurrence of acquired immune deficiency ***,because infection times and other factors are often uncertain,longitudinal studies cannot be conducted directly in the ***,in this study,we performed a longitudinal study on the dynamic changes in the default mode network over time in a rhesus monkey model of simian immunodeficiency virus *** found marked changes in default mode network connectivity in 11 pairs of regions of interest at baseline and 10 days and 4 weeks after virus *** interactions between treatment and time were observed in the default mode network connectivity of regions of interest pairs area 31/V6.R and area 8/frontal eye field(FEF).L,area 8/FEF.L and caudal temporal parietal occipital area(TPOC).R,and area 31/V6.R and *** administered 4 weeks after infection not only interrupted the progress of simian immunodeficiency virus infection but also preserved brain function to a large *** findings suggest that the default mode network is affected in the early stage of simian immunodeficiency virus infection and that it may serve as a potential biomarker for early changes in brain function and an objective indicator for making early clinical intervention decisions.

关键词： acquired immune deficiency syndrome analysis of variance antiretroviral therapy default mode network functional magnetic resonance imaging human immunodeficiency virus longitudinal study rhesus monkeys simian immunodeficiency virus SIV-mac239