The default mode network is affected in the early stage of simian immunodeficiency virus infection:a longitudinal study

作     者：Zhen-Chao Tang Jiao-Jiao Liu Xue-Tong Ding Dan Liu Hong-Wei Qiao Xiao-Jie Huang Hui Zhang Jie Tian Hong-Jun Li Zhen-Chao Tang;Jiao-Jiao Liu;Xue-Tong Ding;Dan Liu;Hong-Wei Qiao;Xiao-Jie Huang;Hui Zhang;Jie Tian;Hong-Jun Li

作者机构：Beijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of Engineering MedicineBeihang UniversityBeijingChina Key Laboratory of Big Data-Based Precision Medicine(Beihang University)Ministry of Industry and Information Technology of the People’s Republic of ChinaBeijingChina Key Laboratory of Molecular ImagingInstitute of AutomationChinese Academy of SciencesBeijingChina Beijing Youan HospitalCapital Medical UniversityBeijingChina Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Institute of Laboratory Animal SciencesChinese Academy of Medical SciencesBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第7期

页      面：1542-1547页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,Nos.82271963(to HJL),81771806(to HJL),61936013(to HJL),82001914(to ZCT),81871511(to HZ) National Key R&D Program of China,No.2021YFA1301603(to ZCT) the Natural Science Foundation of Beijing,No.7212051(to HJL). 

主　　题：acquired immune deficiency syndrome analysis of variance antiretroviral therapy default mode network functional magnetic resonance imaging human immunodeficiency virus longitudinal study rhesus monkeys simian immunodeficiency virus SIV-mac239 

摘      要：Acquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode network.Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network following acquired immune deficiency syndrome infection and antiretroviral therapy.Specifically,when brain imaging data at only one time point are analyzed,determining the duration at which the default mode network is the most effective following antiretroviral therapy after the occurrence of acquired immune deficiency syndrome.However,because infection times and other factors are often uncertain,longitudinal studies cannot be conducted directly in the clinic.Therefore,in this study,we performed a longitudinal study on the dynamic changes in the default mode network over time in a rhesus monkey model of simian immunodeficiency virus infection.We found marked changes in default mode network connectivity in 11 pairs of regions of interest at baseline and 10 days and 4 weeks after virus inoculation.Significant interactions between treatment and time were observed in the default mode network connectivity of regions of interest pairs area 31/V6.R and area 8/frontal eye field(FEF).L,area 8/FEF.L and caudal temporal parietal occipital area(TPOC).R,and area 31/V6.R and TPOC.L.ART administered 4 weeks after infection not only interrupted the progress of simian immunodeficiency virus infection but also preserved brain function to a large extent.These findings suggest that the default mode network is affected in the early stage of simian immunodeficiency virus infection and that it may serve as a potential biomarker for early changes in brain function and an objective indicator for making early clinical intervention decisions.