检索结果-南通市图书馆

High-fidelity carbon dots polarity probes:revealing the heterogeneity of lipids in oncology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第7期11卷 1555-1564页

作者： Jingyu Hu Yuanqiang Sun Xin Geng Junli Wang Yifei Guo Lingbo Qu Ke Zhang Zhaohui Li Colllege of Chemistry Institute of Analytical Chemistry for Life ScienceZhengzhou Key Laboratory of Functional Nanomaterial and Medical TheranosticZhengzhou University450001 ZhengzhouChina Institute of Chemical Biology and Clinical Application at the First Affiliate Hospital Zhengzhou University450001 ZhengzhouChina Department of Chemistry and Chemical Biology Northeastern UniversityBostonMA 02115USA

Polarity is an integral microenvironment parameter in biological systems closely associated with a multitude of cellular *** polarity variations accompany the initiation and development of pathophysiological ***,monitoring the abnormal polarity is of scientific and practical *** state-of-the-art monitoring techniques are primarily based on fluorescence imaging which relies on a single emission intensity and may cause inaccurate detection due to heterogeneous accumulation of the ***,we report carbon dots(CDs)with ultra-sensitive responses to *** CDs exhibit two linear relationships:one between fluorescence intensity and polarity and the other between polarity and the maximum emission *** emission spectrum is an intrinsic property of the probes,independent of the excitation intensity or probe *** features enable two-color imaging/quantitation of polarity changes in lipid droplets(LDs)and in the cytoplasm via in situ emission *** probes reveal the polarity heterogeneity in LDs which can be applied to make a distinction between cancer and normal cells,and reveal the polarity homogeneity in cytoplasm.

关键词： polarity probes revealing

Progress towards revealing the mechanism of herpesvirus capsid maturation and genome packaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2020年第5期11卷 316-317页

作者： Zhihai Li Xuekui Yu Cryo-Electron Microscopy Research Center the CAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China

Members in the family Herpesviridae share a common architecture:the outer envelope,the inner nucleocapsid and the in-between *** are three types of capsids,A-,B-and C-capsids,which are matured from the *** procapsid is assembled in the host cell nucleus where the viral dsDNA genome is *** viral genome is driven into the procapsid by the terminase through the portal,which locates at a unique vertex of the icosahedral capsid(Heming et al.,2017).The A-capsid is empty and is believed to be resulted from unsuccessfully packaging of viral genome.B-capsid contains the scaffold similar to that of the procapsid and is likely resulted from failed initiation of viral DNA packaging.

关键词： revealing packaging likely

revealing the underlying mechanisms behind TE extraordinary THz transmission

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2020年第4期8卷 430-439页

作者： SUZANNA FREER MIGUEL CAMACHO SERGEI A.KUZNETSOV RAFAEL R.BOIX MIGUEL BERUETE MIGUEL NAVARRO-CíA School of Physics and Astronomy University of BirminghamBirmingham B152TTUK Department of Physics and Astronomy University of ExeterExeter EX44QDUK Rzhanov Institute of Semiconductor Physics SB RAS Novosibirsk Branch TDIAM Novosibirsk 630090Russia Physics Department Novosibirsk State UniversityNovosibirsk 630090Russia Department of Electronics and Electromagnetism Faculty of PhysicsUniversity of Seville41012 SevilleSpain Antennas Group-TERALAB Universidad Pública de Navarra31006 PamplonaSpain Institute of Smart Cities Universidad Pública de Navarra31006 PamplonaSpain

Transmission through seemingly opaque surfaces,so-called extraordinary transmission,provides an exciting platform for strong light–matter interaction,spectroscopy,optical trapping,and color *** of the effort has been devoted to understanding and exploiting TM extraordinary transmission,while TE anomalous extraordinary transmission has been largely omitted in the *** is regrettable from a practical point of view since the stronger dependence of the TE anomalous extraordinary transmission on the array’s substrate provides additional design parameters for *** provide high-performance and cost-effective applications based on TE anomalous extraordinary transmission,a complete physical insight about the underlying mechanisms of the phenomenon must be first laid *** this end,resorting to a combined methodology including quasi-optical terahertz(THz)time-domain measurements,full-wave simulations,and method of moments analysis,subwavelength slit arrays under s-polarized illumination are studied here,filling the void in the current *** believe this work unequivocally reveals the leaky-wave role of the grounded-dielectric slab mode mediating in TE anomalous extraordinary transmission and provides the necessary framework to design practical high-performance THz components and systems.

关键词： revealing the underlying mechanisms TE extraordinary transmission THz

Hyperspectral Imaging Technology for revealing the Original Handwritings Covered by the Same Inks

在线全文

学校读者我要写书评

暂无评论

Journal of Forensic Science and Medicine 2017年第4期3卷 210-216页

作者： Yuanyuan Lian Luning Liang Bing Li Key Laboratory of Evidence Science China University of Political Science and LawMinistry of Education 2011 Collaborative Innovation Center of Judicial Civilization Beijing 100088 Fada Institute of Forensic Medicine and Science Beijing 100192 The Ministry of Public Security Material Evidence Identification Center Beijing 100038China

This manuscript presents a preliminary investigation on the applicability of hyperspectral imaging technology for nondestructive and rapid analysis to reveal covered original *** hyperspectral imager Nuance‑Macro was used to collect the reflected light signature of inks from the overlapping *** software Nuance1p46 was used to analyze the reflected light signature of inks which shows the covered original *** types of black/blue ballpoint pen inks and black/blue gel pen inks were chosen for sample *** the hyperspectral images examined,the covered original handwritings of application were revealed in 90.5%,69.1%,49.5%,and 78.6%of the ***,the correlation between the revealing effect and spectral characteristics of the reflected light of inks at the overlapping parts was interpreted through theoretical analysis and experimental *** results indicated that when the spectral characteristics of the reflected light of inks at the overlapping parts were the same or very similar to that of the ink that was used to cover the original handwriting,the original handwriting could not be *** the contrary,when the spectral characteristics of the reflected light of inks at the overlapping parts were different to that of the ink that was used to cover the original handwriting,the original handwriting was revealed.

关键词： Covered original handwritings hyperspectral imaging technology metamerism revealing

Ingenious liquid-observed vapor exchange (LOVE) NMR method revealing how sugars protect dry protein structure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnetic Resonance Letters 2024年第2期4卷 75-76页

作者： Geying Ru Conggang Li Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China

Recently,Gary et *** an article elucidating how sugars contribute to the protection of dry protein *** utilized an ingenious liquid-observed vapor exchange(LOVE)nuclear magnetic resonance(NMR)method,providing valuable insights into the protection mechanism of sugars during the drying *** details of their study can be found in the article available at https://***/10.1021/***.2c00692.

关键词： structure sugar revealing

Facebook——Are You revealing Too Much?

在线全文

学校读者我要写书评

暂无评论

数理天地（初中版） 2019年第10期 48-49页

作者：周越不详

Most young people know what Facebook is:a free-access Internet social networking website popular among teenagers,and adults,*** was founded by a Harvard University student named Mark Zuckerberg and launched on Februar... 详细信息

关键词： Facebook Are You revealing Too Much

sRNAminer,a swiss army knife in small RNA research

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第10期67卷 2289-2290页

作者： Jiawen Zhao Zhonglong Guo Xiaozeng Yang State Key Laboratory of Plant Diversity and Specialty Crops Institute of Botanythe Chinese Academy of SciencesBeijing 100093China Co-Innovation Center for Sustainable Forestry in Southern China College of Life SciencesNanjing Forestry UniversityNanjing 210037China

Small RNAs(sRNAs)are crucial noncoding RNA molecules that regulate gene expression across all kingdoms of life,continually revealing new insights through decades of ***,sRNAs in plants are mainly categorized into microRNAs(miRNAs)and short interfering RNAs(siRNAs),with siRNAs predominantly consisting of phased small interfering RNAs(phasiRNAs)and heterochromatic siRNAs(hc-siRNAs)(Axtell and Meyers,2018).

关键词： sRNA insight revealing

SS-Pro:a simplified siamese contrastive learning approach for protein surface representation

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第5期18卷 243-245页

作者： Ao SHEN Mingzhi YUAN Yingfan MA Manning WANG Digital Medical Research Center School of Basic Medical ScienceFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention Shanghai 200032China

Protein surface serves as an important representation of protein structure,revealing how protein interacts with other biomolecules to perform its *** forms the basis for pharmaceutical and fundamental biological research[1].Datadriven deep learning methods in protein surface representation face challenges of label scarcity,since labeled data are typically obtained through wet lab experiments.

关键词： revealing representation simplified

A booster with SARS-CoV-2 vaccines:protection against Omicron infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第5期7卷 1357-1359页

作者： Yuehong Hu Qiu Sun State Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center for Biotherapy610041ChengduChina Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan University and NHC Key Laboratory of Chronobiology610041ChengduChina

Recently,Wang et *** a study in Nature that examined whether sera from individuals who received two or three doses of the inactivated vaccine could neutralize Omicron.1 Broad-spectrum and potent neutralizing antibodies were isolated from three-dose recipients,which could effectively neutralize strain pseudoviruses and authentic viruses of SARS-CoV-2 of concern(VOCs),including *** addition,the cryo-EM structures of the Omicron spike were elucidated,revealing a new critical immune evasion site and mechanism for the Omicron strain.

关键词： neutral authentic revealing