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Differential regulation of glutathione S-transferase Yb1mRNA levels in rat prostate, liver and brain by androgen

Cell Research 1995年第2期5卷 235-242页

作者： ZHANG YUAN YOUDUAN ZHANG CHAWNSHANG CHANG YONGLIAN ZHANG(Shanghai Institute of Biochemistry, Academia Sinica, 320Yueyang Road, Shanghai 200031, China.)(Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.) Shanghai Institute of Biochemistry Academia Sinica Shanghai China Department of Human Oncology University of Wiscon-sin USA

Northern blot analysis of glutathione S-transferase (GST) Yb1 mRNA in different tissues of male and female rats revealed that its tissue-specific transcription patterns were highly sex hormone related. Although the GST Yb1 mRNA could be detected in most of the tissues examined at various levels, the highest abundance was observed in the ventral prostate, uterus and liver, which were the main target tissue for androgen, estrogen and glucocorticoid respectively The effect of androgen on the transcription of GST Yb1 was also tissue-specific. Since androgen withdrawal by castration caused the up-regulation of GST Yb1 mRNA in the ventral prostate but down-regulation in the liver and no effect in the brain, evaluation of this system for studying the regulation mechanisms of gene expression by which androgen exerts its differential effects has been discussed.

关键词： GST Yb1 mRNA androgen regulation rat prostate rat liver rat brain

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Androgen regulation of rat prostatic steroid binding protein (PSBP) genes transcription

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Progress in Natural Science:Materials International 1995年第1期 8-17页

作者：张永莲 China Chinese Academy of Sciences Shanghai 200031 Shanghai Institute of Biochemistry State Key Laboratory of Molecular Biology

A series of normal and abnormal biological processes such as embryogeny and its development,cell differentiation, hormone regulation and tumour formation, *** in molecular biology terms have been regarded as the results of different related genes expressed differencially in a fine timing and spacial order and under various influences of different physical and chemical factors. The understanding of these elaborative regulation mechanisms will be able to not only provide some clues to understanding the mysteries of the nature but also explore more ways to conquer and remake the nature. In the early 1960s, the discovery of the steroid hormone receptors opened the door to the understanding of steroid hormones actions. Since

关键词： androgen rat prostate PSBP genes transcription regulation.

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