Differential regulation of glutathione S-transferase Yb1mRNA levels in rat prostate, liver and brain by androgen

作     者：ZHANG YUAN YOUDUAN ZHANG CHAWNSHANG CHANG YONGLIAN ZHANG(Shanghai Institute of Biochemistry, Academia Sinica, 320Yueyang Road, Shanghai 200031, China.)(Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.) 

作者机构：Shanghai Institute of Biochemistry Academia Sinica Shanghai China Department of Human Oncology University of Wiscon-sin USA 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：1995年第5卷第2期

页      面：235-242页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

主　　题：GST Yb1 mRNA androgen regulation rat prostate rat liver rat brain 

摘      要：Northern blot analysis of glutathione S-transferase (GST) Yb1 mRNA in different tissues of male and female rats revealed that its tissue-specific transcription patterns were highly sex hormone related. Although the GST Yb1 mRNA could be detected in most of the tissues examined at various levels, the highest abundance was observed in the ventral prostate, uterus and liver, which were the main target tissue for androgen, estrogen and glucocorticoid respectively The effect of androgen on the transcription of GST Yb1 was also tissue-specific. Since androgen withdrawal by castration caused the up-regulation of GST Yb1 mRNA in the ventral prostate but down-regulation in the liver and no effect in the brain, evaluation of this system for studying the regulation mechanisms of gene expression by which androgen exerts its differential effects has been discussed.