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Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues

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Bioactive Materials 2021年第12期6卷 4717-4728页

作者： Xiaohui Wu Xin Wang Xiaobin Chen Xiaowei Yang Qian Ma Guohua Xu Lin Yu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceShanghai Stomatological HospitalFudan UniversityShanghai200438China Department of Orthopedic Surgery Spine CenterChangzheng HospitalNaval Medical UniversityShanghai200003China Zhuhai Fudan Innovation Institute ZhuhaiGuangdong519000China

It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep ***,we designed a novel macromolecular contrast agent with ultrahigh radiopacity(iodinate content>50%)via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol)(PEG).A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us,which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature,were selected as the demonstration *** addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels,but conferred them with excellent X-ray opacity,enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or *** a mouse model,the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging,and their injection volume could be accurately ***,the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative *** particular,the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric *** findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels,and can nondestructively trace and quantify their degradation in ***,the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials.

关键词： Thermosensitive hydrogels radiopacity Block copolymers In vivo degradation Non-invasive deep tissue imaging

Improving the radiopacity of Fe-Mn biodegradable metals by magnetron-sputtered W-Fe-Mn-C coatings:Application for thinner stents

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Bioactive Materials 2022年第6期7卷 64-70页

作者： Samira Ravanbakhsh Carlo Paternoster Gianni Barucca Paolo Mengucci Sofia Gambaro Theophraste Lescot Pascale Chevallier a Marc-Andre Fortin Diego Mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQuebec G1V 0A6Canada Laboratory for Biomaterials in Imaging(BIM) Axe Medecine RegeneratriceCentre Hospitalier Universitaire(CHU)de Quebec-Universite Laval2705boul.Laurier(T1-61a)QuebecG1V 4G2Canada Department of Materials Environmental Sciences and Urban PlanningUniversita Politecnica delle Marchevia Brecce Bianche 1260131AnconaItaly National Research Council Institute of Condensed Matter Chemistry and EnergyCNR-ICMATEVia de Marini 616149GenovaItaly Departement de Genie des Mines de la Metallurgie et des MateriauxCentre de Recherche sur les Materiaux Avances(CERMA)Universite LavalQuebecG1V 0A6Canada Axe Medecine Regeneratrice Centre Hospitalier Universitaire(CHU)de Quebec-Universite Laval2705boul.Laurier(T1-61a)QuebecG1V 4G2Canada

In this exploratory work,micrometric radiopaque W-Fe-Mn-C coatings were produced by magnetron sputtering plasma deposition,for the first time,with the aim to make very thin Fe-Mn stents trackable by *** power of Fe-13Mn-1.2C target was kept constant at 400 W while that of W target varied from 100 to 400 W producing three different coatings referred to as P100,P200,*** effect of the increased W power on coatings thickness,roughness,structure,corrosion behavior and radiopacity was *** coatings showed a power-dependent thickness and W concentration,different roughness values while a similar and uniform columnar *** amorphous phase was detected for both P100 and P200 coatings while γ-Fe,bcc-W and W_(3)C phases found for ***,P200 and P400 showed a significantly higher corrosion rate(CR)compared to *** presence of W,W_(3)C as well as the Fe amount variation determined two different micro-galvanic corrosion mechanisms significantly changing the CR of coatings,0.26±0.02,59.68±1.21 and 59.06±1.16μm/year for P100,P200 and P400,*** P200 with its most uniform morphology,lowest roughness(RMS=3.9±0.4 nm)and good radiopacity(~6%)appeared the most suitable radiopaque biodegradable coating investigated in this study.

关键词： Fe-Mn-Based alloys Degradable coatings W-Fe-Mn-C coatings Magnetron sputtering radiopacity Stent fluoroscopy

Production and characterisation of new bioresorbable radiopaque Mg–Zn–Y alloy to improve X-ray visibility of polymeric scaffolds

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Journal of Magnesium and Alloys 2022年第6期10卷 1694-1703页

作者： Alok Srivastava Naresh Bhatnagar Mechanical Engineering Department Indian Institute of TechnologyDelhiIndia

For the medical diagnosis,radiopaque materials(RM)made from high specific gravity elements like Pt,Au,Ta,Iodine,Bromine are either attached or blended or coated on an implant to makes it detectable under X-ray/Fluoroscopy/*** facilitate the surgeon in an operation theatre to position an implant during the ***,RM are non-degradable,thus in case of biodegradable implants,it may detach from the body and accumulate in vital organ cause serious health ***,a new bioresorbable radiopaque material(BRM)was produced by alloying the high specific gravity elements Zn(35%w/w)and Y(4%w/w)with Mg *** this alloy,three main phases were identified,alpha Mg,Mg_(7)Zn_(3)and icosahedral quasicrystalline I-phase Mg3Zn6Y,which reinforce the Mg ***,BRM was powdered to a size of less than 25 microns and blended in different ratios with bioresorbable poly-L-lactic acid(PLLA)for fabricating PLLA/BRM *** microparticles were uniformly distributed and interfacial bonded with the *** X-ray was passed through bio-composite to captureμCT radiograph for evaluating linear attenuation co-efficient(μ)and optical density(OD).Thermal analysis reveals that BRM particles act as a nucleating site and enhance the crystallinity of the polymeric *** the In Vitro accelerated degradation study,the alkaline nature of BRM neutralise the acidity of PLLA and balance the pH of the body fluid to reduce the inflammatory reactions,but this compromises the stability of the polymer as it increases the decomposition rate.

关键词： Magnesium alloys X-ray Quasicrystal Polymer matrix composites radiopacity

In-chain functionalization through the combination of ring opening copolymerization and oxime "Click" reaction towards X-ray opaque polylactide copolymers

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Chinese Chemical Letters 2020年第2期31卷 551-553页

作者： Wenhuan Wang Lin Sang Weizong Kong Yiping Zhao Zhiyong Wei Yang Li State Key Laboratory of Fine Chemicals Liaoning Key Laboratory of Polymer Science and EngineeringDepartment of Polymer Science and EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China School of Automotive Engineering Dalian University of TechnologyDalian 116024China Department of Gastroenterology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Radiology Second Affiliated Hospital of Dalian Medical UniversityDalian 116027China

X-ray imaging functionalization of biodegradable polyesters is a great demand and challenge in biomedical *** this work,a strategy of in-chain functionalization through the combination of ring opening copolymerization and oxime "Click" postfunctionalization was developed towards X-ray opaque polylactide copolymers.A functionalized cyclic carbonate was first synthesized and used as comonomer of polylactide copolymers,which were subjected to postfunctionalization of oxime "Click" reaction towards iodinated polylactide *** chemical structure and physical properties of the target products were traced and *** vitro cytotoxicity evaluation with 3T3-Swiss albino by Alamar blue demonstrated a low *** X-ray radiopacity was analyzed by Micro-CT and quantified by Hounsfield Units value,which could be tailorable by the *** is a promising X-ray visible implantable biomaterial in biomedical applications.

关键词： Polylactide X-ray radiopacity Iodinated polymer Oxime"Click"reaction In-chain functionalization

A General Strategy for Efficiently Constructing Multifunctional Cluster Fillers Using a Three-Fluid Nozzle Spray Drying Technique for Dental Restoration

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Engineering 2022年第1期8卷 138-147页

作者： Dan-Lei Yang Dan Wang Hao Niu Rui-Li Wang Mei Liu Fei-Min Zhang Jie-Xin Wang Mei-Fang Zhu State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Jiangsu Key Laboratory of Oral Diseases Department of ProsthodonticsAffiliated Hospital of StomatologyNanjing Medical UniversityNanjing 210029China

Multifunctional fillers are greatly required for dental resin composites(DRCs).In this work,a spray dryer with a three-fluid nozzle was applied for the first time to construct high-performance complex nanoparticle clusters(CNCs)consisting of different functional nanofillers for dental *** application of a three-fluid nozzle can effectively avoid the aggregation of different nanoparticles with opposite zeta potentials before the spray drying process in order to construct regularly shaped *** a SiO_(2)–ZrO_(2) binary system,the SiO_(2)–ZrO_(2) CNCs constructed using a three-fluid nozzle maintained their excellent mechanical properties((133.3±4.7)MPa,(8.8±0.5)GPa,(371.1±13.3)MPa,and(64.5±0.7)HV for flexural strength,flexural modulus,compressive strength,and hardness of DRCs,respectively),despite the introduction of ZrO_(2) nanoparticles,whereas their counterparts constructed using a two-fluid nozzle showed significantly decreased mechanical ***,heat treatment of the SiO_(2)-ZrO_(2) CNCs significantly improved the mechanical properties and radiopacity of the *** DRCs containing over 10%mass fraction ZrO_(2) nanoparticles can meet the requirement for radiopaque *** importantly,this method can be expanded to ternary or quaternary *** filled with SiO_(2)-ZrO_(2)-ZnO CNCs with a ratio of 56:10:4 displayed high antibacterial activity(antibacterial ratio>99%)in addition to excellent mechanical properties and ***,the three-fluid nozzle spray drying technique holds great potential for the efficient construction of multifunctional cluster fillers for DRCs.

关键词： Multifunctional cluster fillers Three-fluid nozzle spray drying Mechanical properties Antibacterial activity radiopacity Dental resin composites

Rosuvastatin‑Eluting Gold‑Nanoparticle‑Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model

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Advanced Fiber Materials 2023年第6期5卷 1986-2001页

作者： Carleigh Klusman Benjamin Martin Joy Vanessa D.Perez Allan John R.Barcena Marvin R.Bernardino Erin Marie D.San Valentin Jossana A.Damasco Huckie C.Del Mundo Karem A.Court Biana Godin Gino Martin Canlas Natalie Fowlkes Richard Bouchard Jizhong Cheng Steven Y.Huang Marites P.Melancon Department of Interventional Radiology The University of Texas MD Anderson Cancer CenterHouston 77030USA Baylor College of Medicine Houston 77030USA College of Medicine University of the Philippines Manila1000 ManilaPhilippines Department of Nanomedicine Houston Methodist Research InstituteHouston 77030USA Department of Chemistry Lamar UniversityBeaumont 77710USA Department of Veterinary Medicine and Surgery The University of Texas MD Anderson Cancer CenterHouston 77030USA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHouston 77030USA Section of Nephrology Department of MedicineSelzman Institute for Kidney HealthBaylor College of MedicineHouston 77030USA The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences Houston 77030USA

Arteriovenous fistulas(AVFs)are a vital form of AV access for patients requiring hemodialysis,but they link to overall morbidity and mortality when they fail to *** most common cause of AVF non-maturation is neointimal hyperplasia(NIH).To minimize the deleterious effects of NIH,a perivascular wrap composed of polycaprolactone(PCL),rosuvastatin(ROSU),and gold nanoparticles(AUNPs)was *** study assessed the impact of ROSU-eluting,radiopaque resorbable perivascular wraps on pathologic NIH in a chronic kidney disease(CKD)rodent model of *** PCL wraps containing AuNPs and/or ROSU were monitored for in vitro tensile strength,AuNP release,ROSU elution,and effect on cellular *** wraps were then implanted around an AVF in a CKD rodent model for in vivo ultrasound(US)and micro-computed tomography(mCT)*** specimens were collected for histological *** viability was preserved in the presence of both AuNP-and ROSU-containing *** vitro release of ROSU and AuNPs correlated with in vivo findings of decreasing radiopacity on mCT over ***-loaded wraps had higher radiopacity(1270.0-1412.0 HU at week 2)compared with other wraps(103.5-456.0 HU),which decreased over *** addition of ROSU decreased US and histologic measurements of *** reduced NIH seen with ROSU-loaded perivascular wraps suggests a synergistic effect between mechanical support and anti-hyperplasia ***,AuNP loading increased wrap ***,our results show that AuNP-and ROSU-loaded PCL wraps induce AVF maturation and suppress NIH while facilitating optimal implanted device visualization.

关键词： Arteriovenous fistula Chronic kidney disease Nanoparticles Polycaprolactone radiopacity Rosuvastatin

Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation

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Bioactive Materials 2021年第7期6卷 2105-2119页

作者： Xiaohong Li Xiongfa Ji Kun Chen Muhammad Wajid Ullah Basen Li Jiameng Cao Lin Xiao Jun Xiao Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou510006China Department of Orthopaedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Trans-catheter arterial embolization(TAE)plays an important role in treating various *** available embolic agents lack X-ray visibility and do not prevent the reflux phenomenon,thus hindering their application for TAE ***,we aim to develop a multifunctional embolic agent that combines the X-ray radiopacity with local procoagulant *** barium sulfate nanoparticles(BaSO4 NPs)were synthesized and loaded into the polyvinyl alcohol/chitosan(PVA/CS)to prepare the radiopaque BaSO4/PVA/CS microspheres(MS).Thereafter,thrombin was immobilized onto the BaSO4/PVA/CS MS to obtain the thrombin@BaSO4/PVA/CS *** prepared BaSO4/PVA/CS MS were highly spherical with diameters ranging from 100 to 300μ*** vitro CT imaging showed increased X-ray visibility of BaSO4/PVA/CS MS with the increased content of BaSO4 NPs in the PVA/CS *** biocompatibility assessments demonstrated that the MS were non-cytotoxic and possessed permissible hemolysis *** biofunctionalized thrombin@BaSO4/PVA/CS MS showed improved hemostatic capacity and facilitated hemostasis in ***,in vivo study performed on a rabbit ear embolization model confirmed the excellent X-ray radiopaque stability of the BaSO4/PVA/CS ***,both the BaSO4/PVA/CS and thrombin@BaSO4/PVA/CS MS achieved superior embolization effects with progressive ischemic necrosis on the ear tissue and induced prominent ultrastructural changes in the endothelial *** findings of this study suggest that the developed MS could act as a radiopaque and hemostatic embolic agent to improve the embolization efficiency.

关键词： BaSO_(4) Polyvinyl alcohol/chitosan radiopacity Thrombin Coagulation Embolization