Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues

作     者：Xiaohui Wu Xin Wang Xiaobin Chen Xiaowei Yang Qian Ma Guohua Xu Lin Yu Jiandong Ding 

作者机构：State Key Laboratory of Molecular Engineering of PolymersDepartment of Macromolecular ScienceShanghai Stomatological HospitalFudan UniversityShanghai200438China Department of Orthopedic SurgerySpine CenterChangzheng HospitalNaval Medical UniversityShanghai200003China Zhuhai Fudan Innovation InstituteZhuhaiGuangdong519000China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第12期

页      面：4717-4728页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Authors acknowledge funding from the National Natural Science Foundation of China(grant Nos.51773043,81772363 and 21975045) the National Key R&D Program of China(grant Nos.2020YFC1107102 and 2016YFC1100300) 

主　　题：Thermosensitive hydrogels Radiopacity Block copolymers In vivo degradation Non-invasive deep tissue imaging 

摘      要：It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep ***,we designed a novel macromolecular contrast agent with ultrahigh radiopacity(iodinate content50%)via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol)(PEG).A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us,which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature,were selected as the demonstration *** addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels,but conferred them with excellent X-ray opacity,enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or *** a mouse model,the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging,and their injection volume could be accurately ***,the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative *** particular,the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric *** findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels,and can nondestructively trace and quantify their degradation in ***,the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials.