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The Chinese-German Journal of Clinical Oncology 2007年第4期6卷 405-407页

作者： Juan Wang Weihong Gong Huige Fan Aixia Sui Na Zhao Yongqing Shen Department of Oncology Hebei Provincial People＇s Hospital Shijiazhuang 050051 China

Objective:To observe the possibility of neoplasm needle track implantation after radioactive seeds implantation and seek preventive measures to avoid ***:Superficial tissue of 250 seeding needle cores and 250 stylophores employed in neoplasm radioactive seeds implantation was smeared on slides to search for tumor *** patients received chemotherapy or endocrine therapy after *** B-mode or computer tomography(CT)was performed at 10th day,30th day,60th day,and 180th day post operation to detect neoplasm implantation metastasis through needle tracks. Results:Positive cells were found on 13 of 250(5.20%)cores,and 7 of 250(2.80%)*** difference was not sta- tistically significant(P>0.05).The positive cells frequency of needles those traversed distance less than 3 cm in normal tissue was 6.19%(13/210),while the frequency of the others those traversed longer distance in normal tissue was 2.41%(7/290). The positive cells frequency of needles traversing different distances in normal tissues is significantly different(Pradioactive seed *** preventive measures,such as optimization of pre-operation and intra-operation treatment plan,chemotherapy or endocrine therapy after operation,may be beneficial to avoid the implantation metastasis of neoplasm in seeding needle tracks.

关键词： tumors radioactive seeds puncture neoplasm implantation/metastasis preventions

Implanting iodine-125 seeds into rat dorsal root ganglion for neuropathic pain: neuronal microdamage without impacting hind limb motion

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Neural Regeneration Research 2014年第12期9卷 1204-1209页

作者： Ling Jiao Tengda Zhang Huixing Wang Wenyi Zhang Saijun Fan Xiaodong Huo Baosen Zheng Wenting Ma Institute of Radiation Medicine Chinese Academy of Medical Sciences Second Affiliated Hospital of Tianjin Medical University

The use of iodine-125 （L251） in cancer treatment has been shown to relieve patients＇ pain. Consid- ering dorsal root ganglia are critical for neural transmission between the peripheral and central nervous systems, we assumed that 125I could be implanted into rat dorsal root ganglia to provide relief for neuropathic pain. 125I seeds with different radioactivity （0, 14.8, 29.6 MBq） were im- planted separately through L4-5 and L5-6 intervertebral foramen into the vicinity of the L5 dorsal root ganglion, von Frey hair results demonstrated the mechanical pain threshold was elevated after implanting 125I seeds from the high radioactivity group. Transmission electron microscopy revealed that nuclear membrane shrinkage, nucleolar margination, widespread mitochondrial swelling, partial vacuolization, lysosome increase, and partial endoplasmic reticulum dilation were visible at 1,440 hours in the low radioactivity group and at 336 hours in the high radio- activity group. Abundant nuclear membrane shrinkage, partial fuzzy nuclear membrane and endoplasmic reticulum necrosis were observed at 1,440 hours in the high radioactivity group. No significant difference in combined behavioral scores was detected between preoperation and postoperation in the low and high radioactivity groups. These results suggested that the mechan- ical pain threshold was elevated after implanting 125I seeds without influencing motor functions of the hind limb, although cell injury was present.

关键词： nerve regeneration iodine-125 analgesia radioactive seeds ultrastructure pain threshold dorsal root ganglion injury neuropathic pain neural regeneration

Continuous Low-dose-rate Irradiation of Iodine-125 seeds Inhibiting Perineural Invasion in Pancreatic Cancer

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Chinese Medical Journal 2016年第20期129卷 2460-2468页

作者： Zheng Lu Teng-Hui Dong Pei-Ren Si Wei Shen Yi-Liang Bi Min Min Xin Chen Yan Liu Liver Cirrhosis Diagnosis and Therapy Center 302 Hospital of People's Liberation ArmyBeijing 100039China Department of Gastroenterology and Hepatology 307 Hospital of People's Liberation ArmyAcademy of Military Medical SciencesBeijing 100071China Department of Gastroenterology and Hepatology 107 Hospital of People's Liberation ArmyYantaiShandong 264002China Department of Bioengineering and Therapeutic Sciences University of CaliforniaSan FranciscoCA 94143-0912USA

Background：Perineural invasion （PNI） is a histopathological characteristic of pancreatic cancer （PanCa）.The aim of this study was to observe the treatment effect of continuous low-dose-rate （CLDR） irradiation to PNI and assess the PNI-related pain relief caused by iodine-125 （125I） seed ***：The in vitro PNI model established by co-culture with dorsal root ganglion （DRG） and cancer cells was interfered under 2 and 4 Gy of 125I seeds CLDR *** orthotopic models of PNI were established,and 125I seeds were implanted in *** PNI-related molecules were *** 30 patients with panCa,the pain relief was assessed using a visual analog scale （VAS）.Pain intensity was measured before and 1 week,2 weeks,and 1,3,and 6 months after 125I seed ***：The co-culture of DRG and PanCa cells could promote the growth of PanCa cells and DRG *** co-culture groups,the increased number of DRG neurites and pancreatic cells in radiation group was significantly *** orthotopic models,the PNI-positive rate in radiation and control group was 3/11 and 7/11;meanwhile,the degrees of PNI between radiation and control groups was significant difference （P 〈 0.05）.At week 2,the mean VAS pain score in patients decreased by 50% and significantly improved than the score at baseline （P 〈 0.05）.The pain scores were lower in all patients,and the pain-relieving effect was retained about 3 ***：The CLDR irradiation could inhibit PNI of PanCa with the value of further *** CLDR irradiation could do great favor in preventing local recurrence and alleviating pain.

关键词： Continuous Low-dose-rate Irradiation Pancreatic Cancer Perineural Invasion radioactive seeds

Dosimetry for ^(125) I radioactive seed implantation therapy for hepatocellular carcinoma

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Journal of Nanjing Medical University 2008年第5期22卷 269-272页

作者： Jin Lue Xiufeng Cao Oncology Center the Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 Jiangsu Province China

Hepatocellular carcinoma （HCC） is an aggressive malignancy. Early lesions respond well to hepatic resection or liver transplantation. However, only a few of HCC patients are suitable for surgical intervention. External beam radiation and chemotherapy is poorly efficacious. In the last 20 years, HCCs belonging to the radiosensitive tumor group has been confirmed. Along with the development of new radiotherapy technology and facilities, the research about brachytherapy（especially ^125I seed implantation therapy） has provoked more interests in the world. radioactive seed implantation therapy is a form of interstitial brachytherapy, with the property of local ＂conformal radiotherapy＂ and the advantages of minimal invasion, convenience, high performance, and minimal adverse effects. It is a promising therapy for HCC, however the dosimetry hasn＇ t yet been identified and lacks verification in prospective research. This report aims to further explore the best prescription dose and radioactivity for ^125I interstitial implantation brachytherapy for HCC.

关键词： carcinoma, hepatocellular/radiotherapy brachytherapy radioactive seeds ^125I