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Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction

Neural Regeneration Research 2013年第28期8卷 2641-2648页

作者： Yanan Zhang Sha Yang Xiaonong Fan Shu Wang Nina He Lingxin Li Ding Luo Xuemin Shi First Teaching Hospital of Tianjin University of Traditional Chinese Medicine acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine Key Laboratory of Cerebropathy acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin Key Laboratory of acupuncture & Moxibustion Science Three-level Laboratory of acupuncture Dose-Effect Relationship State Administration of Traditional Chinese Medicine Wuhai Hospital of Traditional Chinese Medicine Department of Rehabilitation Medicine West China Medical SchoolWest China Hospital Sichuan University Postgraduate School Tianjin University of Traditional Chinese Medicine

The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan （PC6） with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. In- teractions between frequency and duration play a critical role in quantified acupuncture therapy.

关键词： neural regeneration acupoint quantified acupuncture Neiguan middle artery occlusion injury lift-ing and thrusting method orthogonal design lifting and thrusting frequency acupuncture duration grants-supported paper neuroregeneration

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