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Effect of Nitrogen Form on the Activity of Tonoplast pyrophosphatase in Tomato Roots

Acta Botanica Sinica 2001年第11期43卷 1146-1149页

作者：朱祝军钱亚榕 Wolfgang PFEIFFER 浙江大学农业与生物技术学院园艺系杭州310029 奥地利萨尔茨堡大学植物生理研究所

Effect of nitrate and ammonium on the activity of tonoplast pyrophosphatase (V-PPase) was investigated in the roots of tomato ( Lycopersicon esculentum L.). The results showed that the activity of V-PPase was increased by ammonium nutrition, compared with nitrate nutrition. The H+ transport of tonoplast vesicles by V-PPase was also stimulated by ammonium nutrition. The result of Western blot indicated that the protein amount of V-PPase was increased by ammonium nutrition.

关键词： tomato nitrogen form tonoplast pyrophosphatase

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Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica

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Science China(Life Sciences) 2022年第3期65卷 618-630页

作者： Xia Wang Jiaxuan Cheng Jiawei Shen Liguo Liu Ningning Li Ning Gao Feng Jiang Qi Jin NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Tsinghua-Peking Center for Life Sciences School of Life SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Peking-Tsinghua Center for Life SciencesSchool of Life SciencesPeking UniversityBeijing 100871China

The extracellular contractile injection systems(e CISs)are encoded in the genomes of a large number of bacteria and *** have previously characterized the overall structure of Photorhabdus Virulence Cassette(PVC),a typical member of the e CIS *** resembles the contractile tail of bacteriophages and exerts its action by the contraction of outer sheath and injection of inner tube plus central ***,the biological function of PVC effectors and the mechanism of effector translocation are still *** combining cryo-electron microscopy and functional experiments,here we show that the PVC effectors Pdp1(a new family of widespread d NTP pyrophosphatase effector in e CIS)and Pnf(a deamidase effector)are loaded inside the inner tube lumen in a"Peas in the Pod"***,we observe that Pdp1 and Pnf can be directly injected into J774 A.1 murine macrophage and kill the target cells by disrupting the d NTP pools and actin cytoskeleton formation,*** results provide direct evidence of how PVC cargoes are loaded and delivered directly into mammalian macrophages.

关键词： Photorhabdus asymbiotica PVC cryo-electron microscopy effector pyrophosphatase

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Role of genetic polymorphisms in hepatitis C virus chronic infection

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World Journal of Clinical Cases 2015年第9期3卷 807-822页

作者： Nicola Coppola Mariantonietta Pisaturo Caterina Sagnelli Lorenzo Onorato Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples Department of Clinical and Experimental Medicine and Surgery "F.Magrassi e A.Lanzara" Second University of Naples

AIM: To analyze the host genetics factors influencing the clinical course and the response to antiviral treatment in patients with chronic hepatitis C(CHC).METHODS: We conducted an electronic search on the Pub Med and MEDLINE(2000-2014) databases and Cochrane library(2000-2014). A total of 73 articles were retrieved and their data were extensively evaluated and discussed by the authors and then analyzed in this review ***: Several studies associated polymorphisms in the interleukin 28 B gene on chromosome 19(19q13.13) with a spontaneous viral clearance in acute hepatitis C and with the response to pegylated interferon(PegIFN)-based treatment in chronic hepatitis C patients. Other investigations demonstrated that inosine triphosphate pyrophosphatase genetic variants protect hepatitis C virus-genotype-1 CHC patients from ribavirin-induced anemia, and other studies that a polymorphism in the patatin-like phospholipase domain-containing protein 3 was associated with hepatic steatosis in CHC patients. Although not conclusive, some investigations suggested that the vitamin D-associated polymorphisms play an important role in the achievement of sustained virologic response in CHC patients treated with Peg-IFN-based antiviral therapy. Several other polymorphisms have been investigated to ascertain their possible impact on the natural history and on the response to treatment in patients with CHC, but the data are preliminary and warrant confirmation. CONCLUSION: Several genetic polymorphisms seem to influence the clinical course and the response to antiviral treatment in patients with CHC, suggesting individualized follow up and treatment strategies.

关键词： Single nucleotide polymorphism Hepatitis C virus infection Interleukin 28B Inosine triphosphate pyrophosphatase Patatin-like phospholipase domaincontaining protein 3

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