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Connexin 43 hemichannels protect bone loss during estrogen deficiency

Bone Research 2019年第2期7卷 183-194页

作者： Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang Department of Orthopaedics Jinan Central Hospital Affiliated to Shandong UniversityJinanShandongChina Department of Biochemistry and Structural Biology UT Health San AntonioSan AntonioTX 78229USA Department of Orthopedics UT Health San AntonioSan AntonioTX 78229USA Department of Biomechanical Engineering University of Texas at San AntonioSan AntonioTX 78249USA

Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone *** 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and *** showed here that estrogen deficiency reduced Cx43 expression and HC *** determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were *** results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty ***,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 *** data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency.

关键词： hemichannels protect estrogen deficiency

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Will a New Myopia Prevention Guideline protect Children’s Eyesight?

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Beijing Review 2020年第19期63卷 46-47页

In some parts of China,where the novel coronavirus disease (COVID-19) pandemic has been effectively contained,schools are being reopened *** a large number of students must continue with online lessons that have alrea... 详细信息

关键词： Guideline protect Children’s Eyesight children

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BASF Offers Innovative Technology to protect China's Coastlines

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China Chemical Reporter 2008年第33期19卷 12-12页

BASF recently introduced a solution to China,which can effectively protect the country’scoastlines against threats from severe or changing Weather *** innovative

关键词： BASF innovative protect

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Establishing a System for Food Recalls to protect Food Quality and Safety in China

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China Standardization 2007年第6期52卷 10-13页

作者： Liu Wen Wang Jing China National Institute of Standardization (CNIS) China National Institute of Standardization (CNIS)

There are no explicit laws concerning food recalls in China; moreover, some related regulations have weaknesses. China should first create a system of laws and regulations governing food recalls, establish a system to... 详细信息

关键词： establishment, food recall system, protect food quality, food safety

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How Should We protect Portrait Rights From Webcast?

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Beijing Review 2019年第25期62卷 46-47页

Recently, a family having dinner in a restaurant in Xi’an, northwest China’s Shaanxi Province, was webcast against i ts will by the restaurant which is popular on the Internet. Discovering what the restaurant was do... 详细信息

关键词： We protect Portrait Rights Webcast

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RNeasy protect Mini Kit对肾活检标本RNA保存和纯化的作用

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肾脏病与透析肾移植杂志 2004年第3期13卷 299-300页

作者：沈茜杨毅孙利徐虹复旦大学附属儿科医院上海200032

生物样品一旦被收集分离，它的RNA极易立刻被降解。由于特异及非特异的RNA降解，或者由于应激反应产生新的RNA都可引起RNA状态的改变。就生物芯片、定量RT-PCR等实验而言，采样后立即稳定样品内RNA以保存当时RNA表达状态，是精确／定量... 详细信息

生物样品一旦被收集分离，它的RNA极易立刻被降解。由于特异及非特异的RNA降解，或者由于应激反应产生新的RNA都可引起RNA状态的改变。就生物芯片、定量RT-PCR等实验而言，采样后立即稳定样品内RNA以保存当时RNA表达状态，是精确／定量研究基因表达分析的重要前提。通常人们采用液氮保存生物样品以防止RNA降解，但操作不方便。

关键词： RNeasy protect Mini Kit 肾活检标本 RNA 生物芯片肾穿刺

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protect:一项预防血栓复发的协调性卒中治疗计划

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 50-51页

作者： Ovbiagele B. Saver J.L. Fredieu A. 李一明 Stroke Center Department of Neurology Univ. of California at Los Angeles 710 Westwood Plaza Los Angeles CA 90095 United States Dr.

Objective: To assess the impact of the Preventing Recurrence of Thromboembolic Events through Coordinated Treatment (protect) Program on achievement of its ei ght secondary prevention goals at the time of discharge. Methods: Achievement ra tes for the eight program goals at time of discharge were compared in all patien ts discharged from a university hospitalbased stroke service with a diagnosis of ischemic st roke or TIA during a 1 year period after implementation of the protect Program vs rates obtained from a comparable group of patients admitted to the same servi ce during the preceding year. Results: Demographic and medical features were com parable in the baseline and intervention cohorts for all patients with cerebral ischemia presumed due to large vessel atherosclerosis or small vessel disease (baseline year n = 117, intervention n = 130). Implementation rates in patients without specific contraindications increased for all four medication goals: 97 t o 100%for antithrombotic agents, 68 to 97%for statins, 42 to 90%for angiotens in converting enzyme inhibitors/angiotensin receptor blockers, and 14 to 70%fo r diuretics. Although data were not collected on baseline lifestyle instruction rates, instruction in the programs four lifestyle interventions was achieved b y discharge in 100%of the intervention cohort. Conclusion: Implementation of th is single center, systems based, inhospital program to initiate secondary stro ke prevention therapies was associated with a substantial increase in treatment utilization at the time of hospital discharge.

关键词：卒中治疗 protect 生活方式指导脑缺血干预组他汀类药物血管紧张素抗凝血药物大学医院受体阻断剂

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“protect AF研究”和“PREVAIL研究”5年随访结果看左心耳封堵所面临的质疑与挑战

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中国介入心脏病学杂志 2018年第10期26卷 597-600页

作者：江立生何奔上海市胸科医院心内科上海交通大学附属上海市胸科医院上海200030

左心耳封堵自2001年开始临床应用至今已走过17个年头,虽然该项技术在国内外获得了快速发展,但仍然受到不少的质疑、甚至挑战。经过梳理发现,这些质疑与挑战主要集中在“理论上是否站得住脚”“技术上是否可行”和“远期效果如何”三个方... 详细信息

左心耳封堵自2001年开始临床应用至今已走过17个年头,虽然该项技术在国内外获得了快速发展,但仍然受到不少的质疑、甚至挑战。经过梳理发现,这些质疑与挑战主要集中在“理论上是否站得住脚”“技术上是否可行”和“远期效果如何”三个方面,笔者针对这三方面的质疑与挑战,根据公开发表的临床研究数据,尤其是新近合并发布的“protect AF研究”和”PREVAIL研究”的5年随访结果[1]谈谈笔者的看法。

关键词： protect AF研究 PREVAIL研究左心耳封堵

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