检索结果-南通市图书馆

Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

引用

World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su Pin-Yu Lai Pei-Hsuan Hu Je-Ming Hu Pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin Chien-An Sun Tsan Yang Chih-Hsiung Hsu Hua-Ching Lin Yu-Ching Chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue prognosis prediction Colorectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation and Refinement of Two Interpretable Models for Coronavirus Disease 2019 prognosis prediction

引用

World Journal of Traditional Chinese Medicine 2023年第2期9卷 191-200页

作者： Kai Chang Ting Jia Ya-Na Zhou Zi-Xin Shu Ji-Fen Liu Jing Sun Qi-Guang Zheng Hao-Yu Tian Jia-Nan Xia Kuo Yang Ning Wang Hai-Long Sun Xin-Yan Wang Deng-Ying Yan Taane G.Clark Bao-Yan Liu Xiao-Dong Li Yong-Hong Peng Xue-Zhong Zhou Institute of Medical Intelligence School of Computer and Information TechnologyBeijing Jiaotong UniversityBejingChina College of Information Engineering Hubei University of Chinese MedicineWuhanHubeiChina Department of Data Center Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Infection Biology London School of Hygiene and Tropical MedicineLondonEngland Department of Infectious Disease Epidemiology Faculty of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineLondonEngland Data Center of Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Computing and Mathematics Manchester Metropolitan UniversityManchesterEngland

Objective:To validate two proposed coronavirus disease 2019(COVID-19)prognosis models,analyze the characteristics of different models,consider the performance of models in predicting different outcomes,and provide new insights into the development and use of artificial intelligence(AI)predictive models in clinical decision-making for COVID-19 and other *** and Methods:We compared two proposed prediction models for COVID-19 prognosis that use a decision tree and logistic regression *** evaluated the effectiveness of different model-building strategies using laboratory tests and/or clinical record data,their sensitivity and robustness to the timings of records used and the presence of missing data,and their predictive performance and capabilities in single-site and multicenter ***:The predictive accuracies of the two models after retraining were improved to 93.2% and 93.9%,compared with that of the models directly used,with accuracies of 84.3% and 87.9%,indicating that the prediction models could not be used directly and require retraining based on actual *** addition,based on the prediction model,new features obtained by model comparison and literature evidence were transferred to integrate the new models with better ***:Comparing the characteristics and differences of datasets used in model training,effective model verification,and a fusion of models is necessary in improving the performance of AI models.

关键词： Coronavirus disease 2019 decision tree interpretable models logistic regression prognosis prediction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis

引用

Science China(Life Sciences) 2021年第9期64卷 1379-1391页

作者： Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijing 100081China Beijing Advanced Innovation Center for Genomics(ICG) Biomedical Pioneering Innovation Center(BIOPIC)School of Life SciencesPeking UniversityBeijing 100871China School of Life Sciences and Beijing Advanced Innovation Center for Structural Biology Tsinghua UniversityBeijing 100084China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)Beijing 100081China College of Chemistry and Molecular Engineering and Beijing National Laboratory for Molecular Sciences Peking UniversityBeijing 100871China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 528107China

Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell ***,a predictor of oral leukoplakia prognosis has not yet been *** investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin *** of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with *** also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up *** malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)***,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia.

关键词： oral leukoplakia copy number alteration prognosis prediction

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/ UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation

引用

Cancer Communications 2018年第1期38卷 714-725页

作者： Cheng Fang Wei Wang Jing-Yu Deng Zhe Sun Sharvesh Raj Seeruttun Zhen-Ning Wang Hui-Mian Xu Han Liang Zhi-Wei Zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China Department of Gastric Cancer Surgery Tianjin Medical University Cancer Institute&HospitalTianjin 300000P.R.China Department of Surgical Oncology The First Hospital of China Medical UniversityShenyang 110000P.R.China

Background:The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control(AJCC/UICC)pathological tumor-node-metastasis(pTNM)staging system may have increased accuracy in predicting prognosis of gastric cancer due to its important modifications from previous ***,the homogeneity in prognosis within each subgroup classified according to the 8th edition may still *** study aimed to compare and analyze the prognosis prediction abilities of the 8th and 7th editions of AJCC/UICC pTNM staging system for gastric cancer and propose a modified pTNM staging system with external ***:In total,clinical data of 7911 patients from three high-capacity institutions in China and 10,208 cases from the Surveillance,Epidemiology,and End Results(SEER)Program Registry were *** homogeneity,discrimina-tory ability,and monotonicity of the gradient assessments of the 8th and 7th editions of AJCC/UICC pTNM staging system were compared using log-rank χ^(2),linear-trend χ^(2),likelihood-ratioχ2 statistics and Akaike information criterion(AIC)calculations,on which a modified pTNM classification with external validation using the SEER database was ***:Considerable stage migration,mainly for stage III,between the 8th and 7th editions was observed in both *** survival rates of subgroups of patients within stage IIIA,IIIB,or IIIC classified according to both editions were significantly different,demonstrating poor homogeneity for patient stratification.A modified pTNM staging system using data from the Chinese cohort was then formulated and demonstrated an improved homogeneity in these abovementioned *** staging system was further validated using data from the SEER cohort,and similar promising results were *** with the 8th and 7th editions,the modified pTNM staging system displayed the highest log-rank χ^(2),linear-trend χ^(2),likelihood-ratio χ^(2),and lowest AIC values,indicatin

关键词： Pathological TNM staging system Gastric cancer Akaike information criterion(AIC) prognosis prediction SEER Chinese

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of an anaplastic lymphoma kinase pathway signature with cell de-differentiation, neoadjuvant chemotherapy response, and recurrence risk in breast cancer

引用

Cancer Communications 2020年第9期40卷 422-434页

作者： Dingxie Liu Yong Wu Bluewater Biotech LLC New ProvidenceMandaluyongNJ 07974USA Division of Cancer Research and Training Department of Internal MedicineCharles R.Drew University of Medicine and ScienceLos AngelesCA 90059USA David Geffen UCLA School of Medicine and UCLA Jonsson Comprehensive Cancer CenterLos AngelesCA 90059USA

Background:Aberrant activation of anaplastic lymphoma kinase(ALK)signaling has been found to be involved in the tumorigenesis of multiple types of *** aim of this study was to determine the role of this pathway in the pathogenesis of breast ***:An ALK pathway signature that we generated previously was used to compute the ALK pathway activity in 6381 breast cancer samples from 42 microarray datasets,and the associations between ALK pathway signature score and clinical variables were examined using logistic regression and survival ***:Our results indicated that high ALK pathway activity was a significant risk factor for hormone receptor-negative,high-grade breast cancer in the 42 *** pathway activity was positively associated with pathological complete response(pCR)in 15 datasets annotated with patient’s neoadjuvant chemotherapy response information(overall odds ratio=1.67,P50 years old,with positive lymph nodes,or with residual disease after neoadjuvant ***:ALK may be involved in breast cancer tumorigenesis,and ALK pathway signature score may serve as a prognostic biomarker for breast cancer.

关键词： Anaplastic Lymphoma Kinase Breast cancer Differentiation Disease free survival Gene signature Neoadjuvant chemotherapy response prognosis prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial intelligence in gastric cancer: Application and future perspectives

引用

World Journal of Gastroenterology 2020年第36期26卷 5408-5419页

作者： Peng-Hui Niu Lu-Lu Zhao Hong-Liang Wu Dong-Bing Zhao Ying-Tai Chen Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Gastric cancer is the fourth leading cause of cancer-related mortality across the globe,with a 5-year survival rate of less than 40%.In recent years,several applications of artificial intelligence(AI)have emerged in the gastric cancer field based on its efficient computational power and learning capacities,such as imagebased diagnosis and prognosis ***-assisted diagnosis includes pathology,endoscopy,and computerized tomography,while researchers in the prognosis circle focus on recurrence,metastasis,and survival *** this review,a comprehensive literature search was performed on articles published up to April 2020 from the databases of PubMed,Embase,Web of Science,and the Cochrane *** the current status of AI-applications was systematically summarized in gastric ***,future directions that target this field were also analyzed to overcome the risk of overfitting AI models and enhance their accuracy as well as the applicability in clinical practice.

关键词： Gastric cancer Image-based diagnosis prognosis prediction Artificial intelligence Machine learning Deep learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial intelligence in small intestinal diseases:Application and prospects

引用

World Journal of Gastroenterology 2021年第25期27卷 3734-3747页

作者： Yu Yang Yu-Xuan Li Ren-Qi Yao Xiao-Hui Du Chao Ren Department of General Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China Trauma Research Center The Fourth Medical Center and Medical Innovation Research Division of the Chinese People‘s Liberation Army General HospitalBeijing 100048China Department of Burn Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China

The small intestine is located in the middle of the gastrointestinal tract,so small intestinal diseases are more difficult to diagnose than other gastrointestinal ***,with the extensive application of artificial intelligence in the field of small intestinal diseases,with its efficient learning capacities and computational power,artificial intelligence plays an important role in the auxiliary diagnosis and prognosis prediction based on the capsule endoscopy and other examination methods,which improves the accuracy of diagnosis and prediction and reduces the workload of *** this review,a comprehensive retrieval was performed on articles published up to October 2020 from PubMed and other *** the application status of artificial intelligence in small intestinal diseases was systematically introduced,and the challenges and prospects in this field were also analyzed.

关键词： Artificial intelligence Machine learning Deep learning prognosis prediction Small intestinal diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding

引用

World Journal of Gastrointestinal Surgery 2024年第3期16卷 790-806页

作者： Jun-Nan Hu Fei Xu Ya-Rong Hao Chun-Yan Sun Kai-Ming Wu Yong Lin Lan Zhong Xin Zeng Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Gastroenterology Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China

BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment *** To develop a new scoring system to predict its *** In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction *** en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during *** models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)*** Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor *** on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the *** with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,*** to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both *** removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was ***,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic *** The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies.

关键词： Upper gastrointestinal bleeding prognosis prediction Retrospective study Nomogram Post-endoscopic model Pre-endoscopic model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

引用

World Journal of Clinical Oncology 2024年第3期15卷 434-446页

作者： Hua Li Yi-Po Ma Hai-Long Wang Cai-Juan Tian Yi-Xian Guo Hong-Bo Zhang Xiao-Min Liu Peng-Fei Liu Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Critical Care Medicine Dingzhou City People’s HospitalDingzhou 073000Hebei ProvinceChina Department of Oncology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Tianjin Marvel Medical Laboratory Tianjin Marvelbio Technology Co.LtdTianjin 300180China Department of Intelligent Technology Tianjin Yunquan Intelligent Technology Co.LtdTianjin 300381China Department of Oncology Tianjin Huanhu HospitalTianjin 300350China

BACKGROUND The ubiquitin-proteasome pathway(UPP)has been proven to play important roles in *** To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these *** In this study,UPP-related E1,E2,E3,deubiquitylating enzyme,and proteasome gene sets were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)database,aiming to screen the prognostic genes using univariate and multivariate regression analysis and develop a prognosis predictive model based RESULTS Five genes(including autophagy related 10,proteasome 20S subunit alpha 8,proteasome 20S subunit beta 2,ubiquitin specific peptidase 17 like family member 2,and ubiquitin specific peptidase 8)were proven significantly correlated with prognosis and used to develop a prognosis predictive model for liver *** training,validation,and Gene Expression Omnibus sets,the overall survival differed significantly between the high-risk and low-risk *** expression of the five genes was significantly associated with immunocyte infiltration,tumor stage,and postoperative recurrence.A total of 111 differentially expressed genes(DEGs)were identified between the high-risk and low-risk groups and they were enriched in 20 and 5 gene ontology and KEGG *** division cycle 20,Kelch repeat and BTB domain containing 11,and DDB1 and CUL4 associated factor 4 like 2 were the DEGs in the E3 gene set that correlated with *** We have constructed a prognosis predictive model in patients with liver cancer,which contains five genes that associate with immunocyte infiltration,tumor stage,and postoperative recurrence.

关键词： Liver cancer Ubiquitin-proteasome pathway prognosis prediction Gene expression Immune infiltration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：