Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis

作     者：Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li Xiaotian Li;Lu Liu;Jianyun Zhang;Ming Ma;Lisha Sun;Xuefen Li;Heyu Zhang;Jianbin Wang;Yanyi Huang;Tiejun Li

作者机构：Department of Oral PathologyPeking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijing 100081China Beijing Advanced Innovation Center for Genomics(ICG)Biomedical Pioneering Innovation Center(BIOPIC)School of Life SciencesPeking UniversityBeijing 100871China School of Life Sciences and Beijing Advanced Innovation Center for Structural BiologyTsinghua UniversityBeijing 100084China Central LaboratoryPeking University School and Hospital of StomatologyBeijing 100081China Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial RegionsChinese Academy of Medical Sciences(2019RU034)Beijing 100081China College of Chemistry and Molecular Engineering and Beijing National Laboratory for Molecular SciencesPeking UniversityBeijing 100871China Institute for Cell AnalysisShenzhen Bay LaboratoryShenzhen 528107China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第9期

页      面：1379-1391页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81671006,81300894,22050002,22050004) Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-038) 

主　　题：oral leukoplakia copy number alteration prognosis prediction 

摘      要：Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell ***,a predictor of oral leukoplakia prognosis has not yet been *** investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin *** of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with *** also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up *** malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)***,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia.