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primary hypertension in a postoperative paraganglioma patient:A case report

World Journal of Clinical Cases 2022年第22期10卷 7931-7935页

作者： Jian-Hui Wei Hai-Li Yan Department of Vasculocardiology Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina

BACKGROUND primary hypertension is a common clinical *** and paraganglioma is a rare cause of secondary *** diagnosis of the latter is still difficult,and the relationship between the two is not *** successful diagnosis of this case confirmed that standardized etiological investigation of secondary hypertension is necessary,contributes to the accurate diagnosis of rare diseases,and is conducive to the formulation or optimization of treatment *** shows an example of the coexistence of primary hypertension and secondary *** SUMMARY The patient was a 54-year-old male and was hospitalized with high blood pressure for 4 *** patient’s blood pressure was measured at 150/100 mmHg during physical examination 4 years ago and had no paroxysmal or persistent elevated blood pressure,no typical triad of headache,palpitation,and sweating,without postural *** taking nifedipine sustained release tablets intermittently,the blood pressure did not meet the *** examination revealed blood pressure of 180/120 *** was no abnormality in cardiopulmonary and abdominal *** results of blood and/or urinary catecholamines/metanephrine and normetanephrine before and after operation were *** examination revealed retinal arteriosclerosis in both *** was a history of paraganglioma diagnosed by pathology after retroperitoneal tumor resection,a family history of hypertension,and a history of passive *** clinical diagnosis was subclinical paraganglioma,primary hypertension,and hypertensive fundus *** patient’s blood pressure was regulated,blood lipid was reduced,and anti-inflammatory,and symptomatic support were *** treatment,the blood pressure was stable and up to standard without discomfort *** Subclinical paraganglioma and primary hypertension can *** holistic thinking in clinical practice is helpful to the early diagnosis of

关键词： Paraganglioma primary hypertension Secondary hypertension Diagnosis and Differential diagnosis Genetic Case report

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Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tran Tat Thang Pham Hong Phuong Nguyen Sa Huynh Nguyen Trung Kien NguyenDuy Toan Nguyen Thi Thu Ha Le Ha Khoa Nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye Hospital Nghe An 43000Vietnam Nghe An Friendship General Hospital Nghe An 43000Vietnam Military Hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam Hanoi Medical University Ha Noi 100000Vietnam Bạch Mai Hospital Ha Noi 100000Vietnam TTH Vinh General Hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scoreshypertension patients was higher than in the control group(41.7%versus 18.8%;Phypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,Phypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,Phypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,Phypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

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Relevant detection indicator of prethrombotic state in patients with primary hypertension

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World Journal of Clinical Cases 2023年第24期11卷 5678-5691页

作者： Jie Luo Tuo Yang Lan Ding Jian-Hui Xiong Teng Ying Fen Xu Medical Technology Department Jiangxi Medical CollegeShangrao 334000Jiangxi ProvinceChina Inspection Department Guangdong Zhanjiang Health School Labor UnionZhanjiang 524094Guangzhou ProvinceChina Department of Medical Technology Jiangxi Medical CollegeShangrao 334000Jiangxi ProvinceChina Department of Cardiology The First Affiliated Hospital of Jiangxi Medical CollegeShangrao 334000Jiangxi ProvinceChina

BACKGROUND hypertension is a common chronic disease that affects many people *** a few reports related to the exploration of relevant indicators of the prethrombotic state in patients with primary hypertension(PH)in clinical settings were *** To detect prethrombotic state-related indicators in patients with PH and analyze their differences in different patient populations to provide a laboratory basis for the clinical prevention and control of hypertensive thrombotic *** The general data of patients with PH who attended the Department of Cardiovascular Medicine,The First Affiliated Hospital of Jiangxi Medical College,from January 2022 to December 2022 were collected *** patients were divided into three groups of 40 patients each according to the Grade of PH:Grade 1,Grade 2,and Grade 3 hypertension experimental *** baseline data of 40 volunteers,who underwent physical examination in our hospital but were not diagnosed with PH during the same period,were included in the control *** relevant indicators of prethrombotic state of the participants were compared,and mainly included inflammation-related indicators,hemorheology-related indicators,and coagulation function related *** relationship between the aforementioned indicators and the progression of PH was *** No significant differences were observed in age,sex,diabetes mellitus,smoking history,drinking history,body mass index,New York Heart Association functional classification,or the course of hypertension among the four groups(P>0.05).The expressions of high-sensitivity C-reactive protein(hs-CRP),thrombomodulin(TM),hematocrit(Hct),erythrocyte sedimentation rate(ESR),P-selectin on platelet surface(CD62P),and fibrinogen(FIB)in the control group werehypertension grouphypertension grouphypertension group,and the expressions of platelet(PLT),activated partial thromboplastin time(APTT),prothrombin(PT),and plasm

关键词： primary hypertension Prethrombotic state Hematocrit P-selectin on platelet surface Activated partial thromboplastin time Erythrocyte sedimentation rate

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Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with primary hypertension and Coronary Artery Disease

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Chinese Journal of Integrative Medicine 2006年第3期12卷 166-170页

作者：程文立柯元南史载祥王瑛陈莉鞠镐范书英 Department of National Integrative Medicine Center for Cardiovascular Diseases China-Japan Friendship HospitalBeijing (100029)

Objective： To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque （OAAP） in patients with primary hypertension and coronary heart disease （PHT-OHD）. Methods： Seventynine patients with PHT-OHD were randomly divided into the treated group （39 patients） treated with garlicin and fosinopril and the control group （40 patients） treated with fosinopril alone. The change of OAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 （IOAM-1） and high sensitive O-reactive protein （hs-ORP） were measured by ELISA, with the observation proceeding for 52 weeks totally. Results： By the end of the experiment, the number of complex plaques, Orouse integrals, intima-media thickness, serum IOAM-1 and hs-ORP were significantly lower in the treated group than those in the control group with significant difference （P〈0.05）. Conclusion： Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.

关键词： garlicin primary hypertension coronary heart disease atherosclerotic plaque intercellular adhesion molecule-1 high sensitive C-reactive protein

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Effect of Yinian Jiangya Yin on primary hypertension in Early Stage—A Clinical Observations on 40 Patients

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Journal of Traditional Chinese Medicine 2010年第3期30卷 171-175页

作者：赵永华刘煜德关莹刘乃维段树民 TCM College Macao University of Science and Technology The First Hospital Affiliated to Guangzhou University of Chinese Medicine

Objective: To observe the effect of Yinian Jiangya Yin (Decoction for lowering blood pressure to prolong life) on patients with early hypertension and its mechanism on the function of vascular endotheliocytes. Methods: The 79 patients with early primary hypertension belonging to the TCM syndrome of stagnation of phlegm and blood stasis in meridians and hyperactivity of the liver-yang were randomly divided into a treatment group of 40 patients treated with Yinian Jiangya Yin and a control group of 39 patients treated with Tianma Gouteng Yin (Decoction of Gastrodia and Uncaria). The changes in score of TCM syndrome and in blood pressure before and after treatment were observed in the two groups. The contents of nitrogen monoxide (NO) and endothelin (ET) in serum after treatment were determined. Results: There was a statistical difference (Pprimary hypertension in early stage and on lowering blood pressure may be related to its regulating the imbalanced condition between ET and NO for restoring the function of endothelium-dependent vasodilation.

关键词： Yinian Jiangya Yin primary hypertension endothelial function stagnation of phlegm and blood stasis in meridians hyperactivity of the liver-yang

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Efficacy of Getong Tongluo Capsule(葛酮通络胶嚢)for Convalescent-Phase of Ischemic Stroke and primary hypertension:A Multicenter,Randomized,Double-Blind,Controlled Trial

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Chinese Journal of Integrative Medicine 2021年第4期27卷 252-258页

作者： ZHAO Qian-yu TANG Rong-hua LU Guo-xiong CAO Xu-zheng LIU Lu-ran ZHANG Ji-hua ZHANG Jin-tao XU Bin WEI Hong-tao YANG Miao WEI Ling ZHANG Mei ZHU Wen-zong WANG Hong LI Hong-lin MA Li-ping ZHONG Chi GAO Yan-jie ZHANG Na REN Shan CHEN Lu LIU Yun-hai CHEN Zhi-gang Department of neurology dongfang hospital affiliated to beijing university of chinese medicinebeijing(100078)china the second school of clinical medicine beijing university of chinese medicinebeijing(100029)china Department of neurology tongji hospital affiliated to tongji medical college of huazhong university of science and technologywuhan(430030)china Department of neurology the hospital affiliated to jiangxi university of traditional chinese medicinenanchang(330006)china Department of neurology the 211th hospital of the people's liberation armyharbin(150000)china Department of neurology the fourth hospital affiliated to harbin medical universityharbin(150000)china Department of neurology the first hospital of suihuasuihuaheilongjiang province(152053)china Department of neurology the 88th hospital of the people's liberation armytai'anshandong province(271000)china Department of neurology xinhua hospital of zhejiang provincehangzhou(310005)china Department of neurology the second provincial people's hospital of gansulanzhou(730000)china i 9.Department of neurology people's hospital of bozhoubozhouanhui province(236800)china Department of neurosurgery the third hospital affiliated to shanxi university of chinese medicinetaiyuan(030000)china Department of neurology the first people's hospital of huainanhuainananhui province(232007)china Department of neurology wenzhou hospital of traditional chinese medicinewenzhouzhejiang province(325000)china Department of neurology the first hospital affiliated to medical college of shihezi universityshihezixinjiang uygur autonomous region(832008)china Department of rehabilitation the second hospital affiliated to heilongjiang university of traditional chinese medicineharbin(150001)china Department of neurology people's hospital of xinzhouxinzhoushanxi province(034000)china Department of neurology people's hospital of weifangweifangshandong province(261000)china Department of neurology xiangya hospital affiliated to central south uni

Objective:To evaluate whether the efficacy of Getong Tongluo Capsule(葛酮通络胶囊,GTC,consisted of total flavone of Radix Puerariae)on improving patients'quality of life and lowering blood pressure are superior to the extract of Ginkgo biloba(EGB)for patients with convalescent-phase ischemic stroke and primary ***:This randomized,positive-drug-and placebo-controlled,double-blind trial was conducted from September 2015 to October *** 477 eligible patients from 18 hospitals in China were randomly assigned in a 2:1:1 ratio to the following interventions,twice a day for 12 weeks:(1)GTC 250 mg plus EGB-matching placebo 40 mg(237 cases,GTC group),(2)EGB 40 mg plus GTC-matching placebo 250 mg(120 cases,EGB group)or(3)GTC-matching placebo 250 mg plus EGB-matching placebo 40 mg(120 cases,placebo group).Moreover,all patients were orally administered aspirin enteric-coated tablets 100 mg,once a day fo r 12 *** primary outcome was the Barthel Index(Bl).The secondary outcomes included the control rate of blood pressure and National Institutes of Health Stroke Scale(NIHSS)*** incidence and severity of adverse events(AEs)were calculated and ***:The Bl relative independence rates,the clinical recovery rates of NIHSS,and the total effective rates of NIHSS in the GTC and EGB groups were significantly higher than the placebo group at 12 weeks after treatment(P0.05).The control rate of blood pressure in the GTC group was significantly higher than the EGB and placebo groups at 12,18 and 24 weeks after treatment(P0.05).Conclusion:GTC exhibited significant efficacy in improving patients'quality of life as well as neurological function and controlling hypertension.

关键词： convalescent-phase of ischemic stroke primary hypertension Getong Tongluo Capsule total flavone of Radix Puerariae randomized controlled trial Chinese medicine

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A novel autoantibody in patients with primary hypertension： antibody against L-type Ca^2＋ channel

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Chinese Medical Journal 2008年第16期121卷 1513-1517页

作者： ZHOU Zi-hua WANG Jun XIAO Hua CHEN Zhi-jian WANG Min CHENG Xiang LIAO Yu-hua Institute of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Background Recently, it has been proposed that the autoantibodies against various cardiovascular receptors play a role in the pathogenesis of primary hypertension. In this study, we aimed to identify whether or not there are autoantibodies against cardiovascular L-type Ca^2＋ channels in patients with primary hypertension. Methods A peptide corresponding to the sequence 2-16 of the alc-subunit of L-type Ca^2＋ channel was used as an antigen to screen the autoantibodies from 90 patients with primary hypertension and 45 healthy controls by an enzyme-linked immunosorbent assay （ELISA）. The clinical data of 90 hypertensive patients were compared between patients with and without these autoantibodies. Results Serum from 3 （6.7%） of the 45 healthy controls, 33 （36.7%） of 90 hypertensives showed positive responses in ELISA （P 〈0.01）. The prevalence of such autoantibodies in two subgroups of hypertensives with coronary heart disease （9/21, 57.14%, P 〈0.05） and left ventricular diastolic dysfunction （28/63, 44.4%, P 〈0.05） was higher than in those without the corresponding complications. And the patients with such autoantibodies had lower E/A than patients without such autoantibodies （0.803±0.191 vs 1.004±0.322, P=0.002）. Conclusion There are autoantibodies against vascular L-tyPe Ca^2＋ channels in patients with primary hvnertension.

关键词： autoantibody primary hypertension L-trpe Ca^2+ channel

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Correlation between angiotensinogen gene and primary hypertension with cerebral infarction in the Li nationality of China

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Neuroscience Bulletin 2007年第5期23卷 287-292页

作者：王埮陈志斌金水晶苏庆杰海南医学院附属医院神经内科海口市570102 海南省干部疗养院神经内科海口市571100

Objective To investigate the relationship of four single nucleotide polymorphism （SNP） haplotypes in the angiotensinogen （AGT） gene to the primary hypertension with or without cerebral infarction in the Li nationality of Hainan, China. Methods Total 300 subjects were allocated into three different groups： Groupl, 100 patients who have primary hypertension; Group 2, 100 patients who have primary hypertension with cerebral infarction; and control group, 100 healthy individuals. The genotypes of all subjects were determined by PCR-sequencing to analyze the four poly- morphisms at position - 152 （G-A）, -20 （A-C）, - 18 （C-T）, and -6 （A-G） in the promoter region of AGT. Results The frequen- cies ofCT genotype of AGT-18 and T allele in Group 1 （P = 0.003, P = 0.004） and Group 2 （P = 0.002, P = 0.002） were both significantly higher than in healthy controls. The frequency of G allele of AGT-6 was significantly higher in Group 2 than in the control group （P = 0.016）, while there is no significant difference between Group 1 and the control. Haplotype analysis revealed that H6 haplotype frequency which included -20C and -6G was significantly increased in Group 2 （P = 0.003） compared with the control group, while H5 haplotype frequency which included -20C and -18T was signifi- cantly increased in Group 1 （P = 0.006） versus the control. Conclusion The -20 （A-C） and - 18 （C-T） of the AGT may play an important role in pathogenesis of primary hypertension; and -20 （A-C）, -18 （C-T）, and -6 （A-G） may be the genetic risk factors for the onset of primary hypertension with cerebral infarction in the Li nationality of Halnan, China.

关键词： angiotensinogen gene primary hypertension cerebral infarction single nucleotide polymorphism haplotype

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The anti-hypertensive effect of time acupuncture on the patients with primary hypertension

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World Journal of Acupuncture-Moxibustion 2020年第4期30卷 272-276页

作者： Yan-jun WANG Xin ZHAO Xiang-dong LAN Shui-qing XU Li-hua ZHANG Affiliated Hospital of Hebei University of Traditional Chinese Medicine Shijiazhuang 050011China Heibei Provincial Chinese Medicine Hospital Shijiazhuang 050011China Cangzhou Integrated Traditional Chinese and Western Medicine Hospital Cangzhou 061000Hebei ProvinceChina

Objective:To observe the anti-hypertensive effect of time acupuncture on primary hypertension so as to provide the therapeutic regimen for the treatment of primary ***:A total of 120 patients with primary hypertension were randomized into a western medication group and an acupuncture-medication group,60 cases in each *** the western medication group,levoamlodipine maleate tablets were prescribed for oral *** the acupuncture-medication group,on the base of the treatment as the western medication group,time acupuncture was combined in the period of a day from 7:00 *** 9:00 *** duration of treatment was 4 weeks in the two *** and after treatment,blood pressure,serum endothelin(ET)and nitrious oxide(NO)were measured successively and the clinical therapeutic effect was ***:(1)Blood pressure:the systolic and diastolic pressure after treatment were all lower than that before treatment in the two groups,indicating statistical differences(all Phypertension was 89%in the acupuncture-medication group,higher than 63%in the western medication group,indicating statistical difference(Pprimary hypertension as compared with simple western medication and its anti-hypertensive effect is probably related to the decrease of ET and the increase of NO.

关键词： Acupuncture primary hypertension Anti-hypertensive effect Acupuncture combines with medication Endothelin(ET) Nitrious oxide(NO)

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Plasma Hemoglobin Was Decreased in Elderly With primary hypertension and/or Type 2 Diabetes Complicated With End-stage Renal Disease

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South China Journal of Cardiology 2009年第2期10卷 53-58页

作者：李刚巩玲俊牟杨朱炳豹 Division of Cardiology Department of Geriatrics The First Affiliated Hospital Chongqing Medical University VIP Ward Ningbo LiHuili Hospital

Objectives To study the change in plasma hemoglobin concentration in elderly patients with primary hypertension and/or type 2 diabetes complicated with end-stage renal disease （ESRD） determined by estimated glomerular filtration rate. Methods Two hundred and thirty cases of Chinese patients aged 60 years or older with primary hypertension and/or type 2 diabetes complicated with chronic kidney disease were enrolled in the study. Patients with chronic kidney disease were divided into ESRD group with estimated glomemlar filtration rate less than 15 mL . min^-1.1.73 m^-2 （7.80 ± 3. 14 mL. min^-1 . 1.73 m^-2） and non-ESRD group with estimated glomerular filtration rate 15 ***^-1 . 1.73 m^-2（29. 76 ± 12. 90 ***^-1 . 1.73 m^-2） or higher. The plasma hemoglobin concentration was compared between the above two groups retrospectively. Results There was significant decrease in plasma hemoglobin concentration in ESRD group compared with non-ESRD group （74.4 ± 22. 5 g/L vs 100. 8 ± 23.0 g/L, P 〈 0. 05 ）. After stratification by sex, there was also significant decrease in plasma hemoglobin concentration both in male and female of ESRD groups compared with their respective non-ESRD groups（77. 2±22. 0 g/L vs 104. 9 ±20. 7 g/L; 69. 7 ±22. 8 g/L vs 96.4± 24.8 g/L, P 〈 0. 05, respectively）. Plasma hemoglobin concentration was positively related to estimated glomerular filtration rate significantly in patients with ESRD （ P 〈 0. 05 ）. Conclusions Plasma hemoglobin concentration is decreased significantly, and is positively related to estimated glomerular filtration rate significantly in elderly patients with primary hypertension and/or type 2 diabetes complicated with ESRD determined by estimated glomerular filtration rate.

关键词： primary hypertension type 2 diabetes end-stage renal disease estimated glomerular filtration rate plasma hemoglobin concentration

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