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Association of point in range withβ-cell function and insulin sensitivity of type 2 diabetes mellitus in cold areas

Frigid Zone Medicine 2023年第4期3卷 242-252,I0014页

作者： Yanan Ni Dan Liu Xiaona Zhang Hong Qiao Department of Endocrinology NO.2 Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Biostatistics Harbin Medical UniversityHarbin 150086China

Background and Objective:Self-monitoring of blood glucose(SMBG)is crucial for achieving a glycemic target and upholding blood glucose stability,both of which are the primary purpose of anti-diabetic ***,the association between time in range(TIR),as assessed by SMBG,andβ-cell insulin secretion as well as insulin sensitivity remains ***,this study aims to investigate the connections between TIR,derived from SMBG,and indices representingβ-cell functionality and insulin *** primary objective of this study was to elucidate the relationship between short-term glycemic control(measured as points in range[PIR])and bothβ-cell function and insulin ***:This cross-sectional study enrolled 472 hospitalized patients with type 2 diabetes mellitus(T2DM).To assessβ-cell secretion capacity,we employed the insulin secretion-sensitivity index-2(ISSI-2)and(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index,while insulin sensitivity was evaluated using the Matsuda index and *** SMBG offers glucose data at specific point-in-time,we substituted TIR with *** to clinical guidelines,values falling within the range of 3.9-10 mmol were considered"in range,"and the corresponding percentage was calculated as ***:We observed significant associations between higher PIR quartiles and increased ISSI-2,(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index,Matsuda index(increased)and HOMA-IR(decreased)(all P<0.001).PIR exhibited positive correlations with log ISSI-2(r=0.361,P<0.001),log(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index(r=0.482,P<0.001),and log Matsuda index(r=0.178,P<0.001)and negative correlations with log HOMA-IR(r=-0.288,P<0.001).Furthermore,PIR emerged as an independent risk factor for log ISSI-2,log(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index,log Matsuda index,and log ***:PIR can serve as a valuable tool for assessingβ-cell function and insulin sensitivity.

关键词： time in range points in range self-monitoring of blood glucose β-cell function insulin sensitivity

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