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Emerging hemostatic materials for non-compressible hemorrhage control

National Science Review 2022年第11期9卷 223-239页

作者： Ruonan Dong Hualei Zhang Baolin Guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong University Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University

Non-compressible hemorrhage control is a big challenge in both civilian life and the battlefield, causing a majority of deaths among all traumatic injury mortalities. Unexpected non-compressible bleeding not only happens in pre-hospital situations but also leads to a high risk of death during surgical processes throughout in-hospital treatment. Hemostatic materials for pre-hospital treatment or surgical procedures for non-compressible hemorrhage control have drawn more and more attention in recent years and several commercialized products have been developed. However, these products have all shown non-negligible limitations and researchers are focusing on developing more effective hemostatic materials for non-compressible hemorrhage control. Different hemostatic strategies(physical, chemical and biological)have been proposed and different forms(sponges/foams, sealants/adhesives, microparticles/powders and platelet mimics) of hemostatic materials have been developed based on these strategies. A summary of the requirements, state-of-the-art studies and commercial products of non-compressible hemorrhage-control materials is provided in this review with particular attention on the advantages and limitations of their emerging forms, to give a clear understanding of the progress that has been made in this area and the promising directions for future generations.

关键词： non-compressible hemorrhage control commercialized hemorrhage-control strategies hemostatic sponge hydrogel microparticle platelet mimics

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