Emerging hemostatic materials for non-compressible hemorrhage control

作     者：Ruonan Dong Hualei Zhang Baolin Guo Ruonan Dong;Hualei Zhang;Baolin Guo

作者机构：State Key Laboratory for Mechanical Behavior of Materialsand Frontier Institute of Science and Technology Xi'an Jiaotong University Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2022年第9卷第11期

页      面：223-239页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：jointly supported by the National Natural Science Foundation of China (51973172) the Natural Science Foundation of Shaanxi Province (2020JC-03 and 2019TD-020) the State Key Laboratory for Mechanical Behavior of Materials,the World-Class Universities (Disciplines) Characteristic Development Guidance Funds for the Central Universities the Fundamental Research Funds for the Central Universities 

主　　题：non-compressible hemorrhage control commercialized hemorrhage-control strategies hemostatic sponge hydrogel microparticle platelet mimics 

摘      要：Non-compressible hemorrhage control is a big challenge in both civilian life and the battlefield, causing a majority of deaths among all traumatic injury mortalities. Unexpected non-compressible bleeding not only happens in pre-hospital situations but also leads to a high risk of death during surgical processes throughout in-hospital treatment. Hemostatic materials for pre-hospital treatment or surgical procedures for non-compressible hemorrhage control have drawn more and more attention in recent years and several commercialized products have been developed. However, these products have all shown non-negligible limitations and researchers are focusing on developing more effective hemostatic materials for non-compressible hemorrhage control. Different hemostatic strategies(physical, chemical and biological)have been proposed and different forms(sponges/foams, sealants/adhesives, microparticles/powders and platelet mimics) of hemostatic materials have been developed based on these strategies. A summary of the requirements, state-of-the-art studies and commercial products of non-compressible hemorrhage-control materials is provided in this review with particular attention on the advantages and limitations of their emerging forms, to give a clear understanding of the progress that has been made in this area and the promising directions for future generations.