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Effects of Xuezhikang Capsule(血脂康胶囊) on Blood Lipids,platelet Activation and Coagulation-Fibrinolysis Activity in Patients with Hyperlipidemia

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Chinese Journal of Integrated Traditional and Western Medicine 2004年第4期10卷 259-262页

作者：刘志高余细勇 Department of Cardiology Affiliated Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan (430077) Guangdong Provincial Institute of Cardiovascular Diseases Guangzhou

Objective: To investigate the effects of Xuezhikang capsule (XZK,血脂康胶囊) on blood lipids level, platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia. Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups, the XZK group (n=38) treated with XZK 600mg, taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day, with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C), plasma GMP-140, fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control. Results: Before treantment the levels of TC, TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P0.05), instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment (Pplatelet activity and improve coagulation-fibrinolysis function, besides its lipids lowering effect.

关键词： Xuezhikang capsule Simvastatin hyperlipidemia platelet α-granule membrane glycopro-tein hyperlipidemia coagulation-fibrinolysis

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