Effects of Xuezhikang Capsule(血脂康胶囊) on Blood Lipids,Platelet Activation and Coagulation-Fibrinolysis Activity in Patients with Hyperlipidemia

作     者：刘志高 余细勇 

作者机构：Department of Cardiology Affiliated Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan (430077) Guangdong Provincial Institute of Cardiovascular Diseases Guangzhou 

出 版 物：《Chinese Journal of Integrated Traditional and Western Medicine》 (中国中西医结合杂志（英文版）)

年 卷 期：2004年第10卷第4期

页      面：259-262页

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：Xuezhikang capsule Simvastatin hyperlipidemia platelet α-granule membrane glycopro-tein hyperlipidemia coagulation-fibrinolysis 

摘      要：Objective: To investigate the effects of Xuezhikang capsule (XZK,血脂康胶囊) on blood lipids level, platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia. Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups, the XZK group (n=38) treated with XZK 600mg, taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day, with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C), plasma GMP-140, fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control. Results: Before treantment the levels of TC, TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P0.05), instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment (P0.05 or P0.01). Conclusion: XZK could inhibit platelet activity and improve coagulation-fibrinolysis function, besides its lipids lowering effect.