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Phenylpropanoids as the biologically active compounds of the medicinal plants and phytopharmaceuticals

Advances in Biological Chemistry 2013年第1期3卷 26-28页

作者： Vladimir A. Kurkin Department of Pharmacognosy Samara State Medical University Samara Russia

In the present paper are discussed the results of the investigations of the phenylpropanoids of the medicinal plants which are of the great interest as the sources of the neurotropic, adaptogenic, immunostimulating, antioxidative, and hepatoprotective preparations. There were shown the necessity of using of the standard samples of triandrin (Rhodiola rosea L. tissue cultures, Salix viminalis L. barks), rosavin (Rhodiola rosea L. rhizomes), syringin, or eleutheroside B [Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. rhizomes, Syringa vulgaris L. barks], and silybin [Silybum marianum (L.) Gaertn. fruits] for purpose of the standardization of the corresponding drugs and pharmaceuticals. It was shown also the significance of γ-schizandrin, chicoric acid, rosmarinic acid and lavandoside for purposes of the standardization of raw material and preparations of Schizandra chinensis Baill. fruits and seeds, Echinacea purpurea (L.) Moench. herbs, Melissa officinalis L. herbs and Lavandula spica L. flowers respectively.

关键词： Phenylpropanoids Medicinal Plants phytopharmaceuticals Standardization Neurotropic Adaptogenic Hepatoprotective Antioxidative Immunomodulating Activities

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Xenobiotics-Induced Liver Damage Is Biochemically Abrogated by Treatment with Lipophilic Extracts of <i>Moringa oleifera in Vivo</i>

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Health 2018年第3期10卷 313-325页

作者： Maxwell Omabe Kenneth Nwobini Omabe David Igwe Ogbonnaya Chukwu John Samuel Kalu Uchenna Sunday Elom Department of Oncology Cancer Research Division Immunology Group University of Saskatchewan Saskatoon Canada Diagnostic Molecular Biology Research Group Molecular Pathology and Immunology Division Chemical Pathology & Histopathology Unit Department of Medical Laboratory Sciences School of Biomedical Science Faculty of Health Science Ebonyi State University Abakaliki Nigeria Department of Molecular Biology Faculty of Natural Sciences Federal University Abakaliki Nigeria Department of Trauma and Orthopaedic Rotherham NHS Trust Rotherham UK Department of Medical Biochemistry Faculty of Basic Medical Sciences Federal University Abakaliki Nigeria

Context Drug-induced hepatotoxicity represents a significant proportion of liver disease cases. Currently, there is no effective treatment. To date efforts to identify treatment regimen that can reverse progressive damage have not been successful. We have previously shown that extract from Moringa (M) oleifera possesses clinically relevant antidiabetic and electrolyte modulators. Objective The aim of the current studies is to create experimental model of xenobiotic induced liver damage and investigate if treatment with lipophilic extract of M. oleifera could biochemically reverse progressive liver damage. Materials and Method For two groups of healthy rats, 7 in each group received 200 mg of extract or vehicle twice daily for 14 days. Acute toxicity, hepatotoxicity and hematologic/endothelial toxicity were monitored. Then 30 rats weighing 130 - 200 g received repeated dose of acetaminophen (xenobiotics) (640 mg/kg) for 5 days. Hepatotoxicity was confirmed biochemically by an established protocol. Treatment with M. oleifera extract resulted in mean weight of 132.2 ± 5.05 compared to the control with 134.1 ± 5.08 (P > 0.8115) among the healthy rats. Their LDH levels were 170.7 ± 13.02 and 133.8 ± 7.17 (P > 0.0698) for controls group, while the mean serum (ALT) level was 12.4 ± 1.2 or 25.6 ± 5.644 (P M. oleifera resulted in 100% biochemical recovery from hepatitis compared to the control group (P M. oleifera could effectively and biochemically abrogate xenobiotics induced liver damage in animal model.

关键词： phytopharmaceuticals Phytomedicine Drug Discovery Inflammation Alanine-Aminotransferase Haematological Toxicity Lactate Dehydrogenase Hepatitis

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Dendrobium orchid polysaccharide extract: Preparation,characterization and in vivo skin hydrating efficacy

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Chinese Herbal Medicines 2019年第4期11卷 400-405页

作者： Mayuree Kanlayavattanakul Tamonpatch Pawakongbun Nattaya Lourith School of Cosmetic Science Mae Fah Luang UniversityChiang Rai 57100Thailand Phytocosmetics and Cosmeceuticals Research Group Mae Fah Luang UniversityChiang Rai 57100Thailand

Objective:Dendrobium spp.,the major globally commercializing tropical orchid,has been continuously used in Chinese ***,preparation and standardization of this therapeutic orchid including its clinical evidence for topical application are sparely to be ***:Maceration of the white orchid(Dendrobium *** Sanan)in water was varied on the extraction *** extraction yields and total polysaccharide content of the extracts were *** best extract condition was selected,standardized,and evaluated on safety and skin hydrating efficacy in human ***:The extraction for 3 h gave the extract with polysaccharide content that significantly(P<0.001)greater than the other extraction times with the following specification:yield[(35.60±2.51)%],moisture content[(7.65±0.21)%],total polysaccharide,sugar,reducing sugar and ash content[(72.95±2.37)%,(34.38±0.00)%,(16.28±0.00)%,and(0.12±0.00)%],p H(4.42±0.01),viscosity[(15.07±0.12)cps]swelling and water absorption capacities[(10.00±0.00)%,(1.19±0.24)g/g].This antioxidative polysaccharide caused no skin irritation with a better skin hydrating efficacy than the untreated skin and the benchmark as examined in 22 Thai ***:White Dendrobium is ready to be supplied as a specialty ingredient with a safe and efficient profile for skin dryness *** innovative application of the identified traditional Chinese medicinal herb flows in the main stream of the consumers’preferences and demand upon natural derived products.

关键词： clinical study moisturizer orchid phytopharmaceuticals polysaccharide skin hydrating

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