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The long-term immunological effects of alloferon and its analogues in the mealworm Tenebrio mofitor

Insect Science 2018年第3期25卷 429-438页

作者： Elzbieta Czarniewska Arkadiusz Urbanski Szymon Chowanski Mariola Kuczer Department of Animal Physiology and Development Adam Mickiewicz University Umultowska 89 61-614 Poznan Poland Faculty of Chemistry Wroclaw University Joliot-Curie 14 50-383 Wroctaw Poland

The subject of this article is a search for the long-term immunological effects of alloferon and 3 structural analogues of alloferon, which were earlier characterized by the highest pro-apoptotic activity in Tenebrio molitor. The differences in the actions of these peptides on immune response were observed. Alloferon increased nodulation and significantly phenoloxidase activity in the hemolymph of experimentally infected T. molitor. However, [Phe（p-NH2）^1 ]- and [Phe（p-OMe） ^1 ]-alloferon strongly inhibited cellular and humoral defense of the mealworm against Staphylococcus aureus infection. One day after injection of these peptides, the specific biochemical and morphological hallmarks of apoptosis in bacteria-challenged hemocytes were visible; in contrast, 3 days after peptides injection in all hemocytes, caspase activation was not observed. However, these new, circulating hemocytes differed from the control and the peptide-untreated bacteria-challenged hemocytes. They had an increased adhesion that led to a separation of viable, anucleated fragments of hemocytes that retain the ability to adhere and to form long filopodia. The peptide-induced separation ofhemocyte fragments may resemble the formation ofplatelets in mammals and perhaps play a role in sealing wounds in insects. The results of in vivo studies may suggest a long half-life of studied peptides in the hemolymph of mealworm. Moreover, we showed the importance of the N-terminal histidine residues at position one of the alloferon molecule for its immunological properties in insects. The results obtained here show that alloferon plays pleiotropic functions in insects.

关键词： alloferon analogue hemocyte's apoptosis immune response nodulation phenoloxidase activity

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Effects of Dietary Vitamin C on the Immune Function of Shrimps, Penaeus chinensis

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Journal of Ocean University of Qingdao 2002年第1期1卷 50-54页

作者： WANGWeiqing LIAijie CheungSiugin SchoolofFisheries OceanUniversityofQingdaoQingdao266003P.R.China DepartrnentofBiology＆Chemistry CityUniversityofHongKongHongKongP.R.China

Prepared in this experiment were six groups of diets, i.e. VC0, VC1, VC2, VC3, VC4 and VC5 with the contents of vitamin C (VC mg(100 g) -1 diet) of 0, 100, 200, 400, 800, and 1200 respectively. It was found that vitamin C increased the concentrations of immunoglobulin-like (IgG-like, IgA-like and IgM-like) substances in the serum of Penaeus chinensis after a feeding period of 3 weeks. The differences among groups were significant (P0.05). phenoloxidase (PO) activity in the serum of VC3 group shrimps was higher than that of VC0 and other groups, but no significant difference was observed between VC0 group and other groups. Furthermore, bactericidal activity of the serum to Vibrio parahaemolyticus in shrimps fed with the VC1 diet was higher than that in the other groups (Pactivity to Vibrio alginolyticus (P>0.05). It is, therefore, suggested that vitamin C (100-400 mg(100 g) -1 diets) could be used as an immunostimulant of P. chinensis.

关键词： Penaeus chinensis vitamin C immune function phenoloxidase activity

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