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pharmacological effects of denervated muscle atrophy due to metabolic imbalance in different periods

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BIOCELL 2023年第11期47卷 2351-2359页

作者： JIAYING QIU YAN CHANG WENPENG LIANG MENGSI LIN HUI XU WANQING XU QINGWEN ZHU HAIBO ZHANG ZHENYU ZHANG Department of Prenatal Screening and Diagnosis Center Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Nantong Institute of Genetics and Reproductive Medicine Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Department of Emergency Medicine Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Medical School of Nantong University Nantong UniversityNantong226001China School of Life Sciences Nantong UniversityNantong226001China

Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of *** pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation ***,an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages,along with targeted treatment and protection,becomes essential for effective atrophy *** preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray *** review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation and muscle ***,drugs targeting the reactivare oxygen species stage and the inflammation stage assume critical *** intervention during the initial atrophy stages can expedite protection against skeletal muscle ***,pharmaceutical intervention in the ubiquitin-proteasome pathway associated with atrophy and autophagy lysosomes can effectively slow down skeletal muscle *** molecules within this stage encompass MuRF1,MAFbx,LC3II,p62/SQSTM1,*** review also compiles a profile of drugs with protective effects against skeletal muscle atrophy at distinct postdenervation stages,thereby augmenting the evidence base for denervation-induced skeletal muscle atrophy treatment.

关键词： pharmacological effects Denervated muscle atrophy Metabolic imbalance

Research progress on the pharmacological effects and chemical constituents of Pien Tze Huang and its potential Q-markers

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Chinese Journal of Natural Medicines 2023年第9期21卷 658-669页

作者： DONG Zhaomin WANG Hong WANG Guangji Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China

Pien Tze Huang(PTH)was documented as an imperial prescription composed of Notoginseng Radix,Calculus Bovis,Snake Gallbladder,and *** is famous in China and Asian countries due to its excellent effects in heat clearing,detoxifying,swelling reduction,and pain *** pharmacological studies demonstrate that PTH shows excellent effects against various inflammatory diseases,liver diseases,and *** review summaries the pharmacological effects,clinical applications,and mainchemical components of *** importantly,its potential quality markers(Q-markers)were then analyzed based on the“five principles”of Q-markers under the guidance of Traditional Chinese Medicine theory,including transfer and traceability,specificity,efficacy,compatibility,and *** a result,ginsenosides Rb1,ginsenoside Rg1,ginsenoside Rd,ginsenoside Re,notoginsenoside R1,dencichine,bilirubin,biliverdin,taurocholic acid,and muscone are considered as the Q-markers of *** findings will provide guidance and assistance for the construction of a quality control system for PTH.

关键词： Pien Tze Huang(PTH) Quality marker(Q-marker) Chemical components pharmacological effects Clinical application Qualitycontrol

A mini-review on pharmacological effects of ginsenoside Rb3,a marked saponin from Panax genus

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BIOCELL 2022年第6期46卷 1417-1423页

作者： WEI LI YUEYANG DUAN XIAOTONG YAN XIANGXIANG LIU MEILING FAN ZI WANG College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun130118China National&Local Joint Engineering Research Center for Ginseng Breeding and Development Changchun130118China Maternity Diagnosis&Treatment Center The Affiliated Hospital of Changchun University of Chinese MedicineChangchun130021China

Ginsenoside Rb3(G-Rb3)is one of the primary active compounds isolated from Panax ginseng Meyer,which belongs to protopanaxadiol ginsenosides(PPD).Based on the structure-activity relationship(SAR)of ginsenosides,the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain ***,pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins,such as Compound K,F2,etc.A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials,which was achieved by diminishing oxidative stress and ***,more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical *** article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.

关键词： Ginsenoside Rb3 pharmacological effects Review Signaling pathway

Research Progress on Chemical Constituents and pharmacological effects of Celosia L.

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Chinese Medicine 2023年第4期14卷 255-266页

作者： Shutong Li Science of Chinese Materia Medica Chengdu University of Traditional Chinese Medicine Chengdu China

Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. Which have a variety of effects such as antimicrobial, hepatoprotective and antitumour. To provide a scientific foundation for the subsequent phase of research and development for Celosia L., 30 years of pertinent global literature is summarized, analyzed, and categorized. An overview of 75 chemical constituents, pharmacological activities, and clinical applications is provided.

关键词： Celosia L. Chemical Constituents pharmacological effects

Research review on the main chemical constituents and pharmacological effects of Tripterygium hypoglaucum (Levl.) Hutch.

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Asian Journal of Traditional Medicines 2022年第3期17卷 94-107页

作者： Yunfei Ai Shuhui Dong Xiaoxiao Huang Shaojiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Tripterygium hypoglaucum(Levl.)Hutch.(THH),which belongs to Tripterygium genus of Celastraceae family,is widely used as the common Chinese herbal *** has been reported that the chemical constituents of *** include monoterpenoids,sesquiterpenoids,diterpenoids,triterpenoids,sesquiterpene alkaloids,flavonoids,anthraquinone derivatives,et *** compounds showed a wide range of bioactivities,such as anti-inflammatory,anti-cancer,immunosuppressive,anti-HIV,anti-fertility and insecticidal *** this paper,we summarized the chemical constituents and pharmacological activities of *** to provide a reference for its further research and developement.

关键词： Tripterygium hypoglaucum. chemical constituents pharmacological effects review

Advances in Research of pharmacological effects and Molecular Mechanisms of Daurisoline

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Medicinal Plant 2022年第3期13卷 87-91页

作者： Quan QUAN Chenghao JIN College of Life Science and Technology Heilongjiang Bayi Agricultural University Daqing 163319 China

Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family *** to its pharmacological effects such as anti-arrhythmia,anti-ischemia and anti-cancer,daurisoline has attracted wide attention of *** this paper,the pharmacological effects and action mechanism of daurisoline were reviewed in combination with relevant research literature,to provide a theoretical basis for the development and clinical application of daurisoline.

关键词： Daurisoline pharmacological effects Calcium regulation Anticancer

Chemical constituents,biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver

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Food Science and Human Wellness 2019年第2期8卷 177-188页

作者： Yi-Fan Xing Dong He Yi Wang Wen Zeng Chong Zhang Yuan Lu Nan Su Yan-Hua Kong Xin-Hui Xing Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringRoom 601Yingshi BuildingBeijing 100084China Centre for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Animal Disease Control and Prevention Centre South Section of Hangu RoadLingbao CityHenan 472500China

Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development ***,the comprehensive utilization rate of *** *** still very low,only bark has been used as medicine and other parts of Eucommia ulmoides *** be fully utilized,even the leaves have been well utilized in food products in Japan in the past *** order to improve the comprehensive utilization efficiency of *** Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of *** *** findings suggest that other parts of *** *** replace the bark of *** *** some extent besides of their respective *** unique and extensive physiological functions between different parts of *** *** that the comprehensive utilization of *** *** a wide space to develop,which is also an effective way to protect *** *** and improve its the utilization rate.

关键词： Eucommia ulmoides Oliver Comprehensive utilization Chemical constituents Biological functions pharmacological effects

A critical review on chemical constituents and pharmacological effects of Lilium

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Food Science and Human Wellness 2019年第4期8卷 330-336页

作者： Pengyu Wang Jian Li Fatma Alzahra K.Attia Wenyi Kang Jinfeng Wei Zhenhua Liu Changqin Li National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China School of Food Science and Engineering Hefei University of TechnologyHefei 23009China Department of Ornamental Medicinal and Aromatic PlantsFaculty of AgricultureAssiut University71515Egypt Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China

Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological *** researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and *** effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and *** paper summarized chemical constituents and pharmacological effects of Lilium.

关键词： Lilium Chemical constituents pharmacological effects

Advances in research on chemical constituents and pharmacological effects of Paecilomyces hepiali

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Food Science and Human Wellness 2021年第4期10卷 401-407页

作者： Akang Dan Yujia Hu Ruyan Chen Xiangyang Lin Yongqi Tian Shaoyun Wang School of Biological Science and Technology Fuzhou UniversityFuzhou 350108China

Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps *** main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and *** to the huge development potential of *** in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the *** this paper,the chemical constituents and their pharmacological effects of *** are reviewed,which can provide reference for the development and application of ***.

关键词： Paecilomyces hepiali Chemical constituents pharmacological effects