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Underestimated contribution of fugitive emission to VOCs in pharmaceutical industry based on pollution characteristics, odorous activity and health risk assessment

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Journal of Environmental Sciences 2023年第4期126卷 722-733页

作者： Qinhao Lin Zhong Gao Weikun Zhu Jiangyao Chen Taicheng An Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong Technology Research Center for Photocatalytic Technology Integration and Equipment EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangzhou Key Laboratory of Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Fugitive emission has been becoming an important source of volatile organic compounds(VOCs) in pharmaceutical industry,but the exact contribution of fugitive emission remains incompletely *** present study,pollution characteristics,odorous activity and health risk of stack and fugitive emissions of VOCs from four functional units (e.g.,workshop,sewage treatment station,raw material storage and hazardous waste storage) of three representative pharmaceutical factories were *** was the dominant contributor to VOCs of fugitive emission in comparison with other functional *** high concentration of VOCs from fugitive emission in unsealed workshop (94.87 mg/m^(3))was observed relative to sealed one (1.18 mg/m^(3)),accounting for 31%and 5%of total VOCs,*** emission of VOCs in the unsealed workshop mainly consisted of nhexane,1-hexene and *** activity indexes and non-cancer hazard ratios of these VOCs from fugitive emission in the unsealed workshop were as high as that from stack ***,cancer risk of dichloromethane from fugitive emission and stack exhaust was up to (1.6-1.8)×10^(-5).Odorous activity or health risk index of the VOCs from fugitive emission was up to 13 or 11 times of the corresponding threshold value,posing remarkable health threat on pharmaceutical ***?ndings highlighted the possibly underestimated contribution of fugitive emission on VOCs in the pharmaceutical industry.

关键词： pharmaceutical industry VOC pollution Fugitive emission Odorous activity index Health risk

New medical reform and the sustainable development of the pharmaceutical industry in China

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Chinese Medical Journal 2013年第4期126卷 775-782页

作者： ZHOU Yi LI Lan-juan State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

The national economy development and the demanding of the drugs request the pharmaceutical industry in China to keep sustainable development especially under the background of the new medical reform. According to the status of industry development and drug consumption in China, the trend and the driving factors for pharmaceutical industry in the future were estimated. Based on the analysis of the background and conditions for pharmaceutical industry sustainable development in China, the problems and challenges, the goal as well as the main measures for the sustainable development of pharmaceutical industry were put forward.

关键词： sustainable development pharmaceutical industry new medical reform policy environment

Optimization of a Method for the Simultaneous Determination of Phloroglucinol and Trimethylphloroglucinol by High Performance Liquid Chromatography in Routine Use in a pharmaceutical industry in Abidjan

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Open Journal of Optimization 2023年第2期12卷 11-24页

作者： Jean-Kisito Kouamé Mariette Désirée Yéhé Claude Bérenger Ngalemo Ngantchouko Amani Germain Brou Carine Nina Ablé Aya Mélissa Diane Kouadio Bi Gogoua Désiré Vagny Vincent De Paul Ovi Christophe N’cho Amin Gildas Komenan Gbassi National Public Health Laboratory (NPHL) Food Control Service Abidjan Ivory Coast Department of Analytical Sciences and Public Health Training and Research Unit (UFR) of Pharmaceutical and Biological Sciences Félix Houphou&#235t Boigny University Abidjan Ivory Coast Higher Institute of Health Sciences of the University of the Mountains (UdM) Bangangté Cameroon

In order to provide the population with safe, effective and good quality medicines, the pharmaceutical industries, before releasing batches of their products into the pharmaceutical circuit, put in place internal dosage methods to control the quality of these products. The present study consisted in optimizing a method for the simultaneous determination of Phloroglucinol (PHG) and Trimethylphloroglucinol (TPH) by high performance liquid chromatography (HPLC) routinely used in a pharmaceutical industry located in a township in Abidjan (Ivory Coast). The basic chromatographic conditions were those routinely used for the determination of these two molecules: mobile phase: acetonitrile/water (60/40), stationary phase (C18 BDS Hypersil 250 mm * 4.6 mm - 5 μm), detection wavelength (265 nm), flow rate, injection volume and run time configured at the equipment level were respectively 1 mL/min, 10 μL and 8 min. The method of preparation of the analytes (PHG and TPHG) was also applied by the pharmaceutical industry. The application of these different parameters at the equipment level made it possible to determine a chromatogram which highlights three chromatographic peaks with respective retention times (RT) of 0.773 min (unidentified compound), 2.275 min (PHG) and 7.269 min for an analysis time of 8 min with a better resolution of the peaks and baseline. The progressive optimization of different parameters such as the stationary phase (C18 YMC 150 mm * 4.6 mm - 3 μm), the proportion of the mobile phase: acetonitrile/water (80/20), the flow rate impelled by the pump (0.8 mL/min) and the modification of the analyte preparation mode (same amount of PHG and TPHG in a 50 mL volumetric flask) resulted in a final chromatogram that highlighted two chromatographic peaks at the respective RT of 2.391 min (PHG) and 3.735 min (TPHG) at a run time of 6 min. The chromatographic conditions that led to the final chromatogram can be used routinely by the pharmaceutical industry for the dete

关键词： PHG TPHG pharmaceutical industry Chromatographic Profile Chromatographic Peak

Research on the Relationship between Export Orientation and R&D Investment of China’s pharmaceutical industry in Different Regions

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Asian Journal of Social Pharmacy 2021年第1期16卷 48-59页

作者： Qiao Jiahui Wang Su Chen Yuwen School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To study the relationship between export orientation and research and development(R&D)investment so as to provide suggestions and references for improving the R&D investment level and innovation capabilities of pharmaceutical industry due to the progress of globalization and the continuous development of export trade of China’s pharmaceutical *** The relevant data of China’s pharmaceutical industry from 2001 to 2016 was selected to establish an error correction model based on the co-integration theory,and then the Granger causality test was conducted to determine the relationship between the export orientation and R&D investment of China’s pharmaceutical industry in different *** and Conclusion It is found that the export orientation of the pharmaceutical industry in different regions has a significant negative impact on the investment of R&*** them,the middle region has the greatest impact,followed by the eastern and western *** export orientation of the pharmaceutical industry in the middle region has a lag effect on R&D investment,and the lag phase is two years.

关键词： pharmaceutical industry export orientation R&D investment co-integration analysis

The Researches on Salary Fairness against the Background of Marketization: Evidence from Chinese pharmaceutical industry

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The Researches on Salary Fairness against the Background of ...

Research on the Impact of Independent R&D and Collaborative Innovation on Economic Performance in China’s pharmaceutical industry

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作者： Wu Siqi Mikio Kudo Business School Sichuan University International Graduate School of Accounting Policy Tohoku University

Salary fairness is the key to the reform of income distribution mechanisms in China. This research examines salary fairness under the background of marketization, using evidence from Chinese pharmaceutical listed companies. Based on the Rucker coefficient and related theories, a value added statement analysis is conducted. The research results indicate that salary inequity exists in China's pharmaceutical industry. It also suggests that non-state owned enterprises that located in regions with lower marketization level face a more serious problem of salary fairness. Most significantly, it reveals that the shareholders and government claim a larger portion of the value produced by the enterprises than other stakeholders. This is especially true concerning the shareholders who claim the largest share.

关键词： pharmaceutical industry marketization salary fairness Rucker coefficient value added statement analysis

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Asian Journal of Social Pharmacy 2023年第4期18卷 315-325页

作者： Li Wanting Qiao Jiahui Wang Su Chen Yuwen School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To study the impact of independent R&D and collaborative innovation on economic performance in the pharmaceutical *** A panel regression model was established by selecting the panel data of China’s pharmaceutical industry from 2009 to *** and Conclusion Independent R&D and collaborative innovation of the pharmaceutical industry in eastern,central and western regions of China had a positive effect on economic ***,the promotion effect of independent R&D was greater than that of collaborative *** positive driving effect of economic performance is the largest among the three regions,followed by the central and western *** collaborative innovation has the greatest positive effect on economic performance in the central region,followed by the eastern and western regions.

关键词： independent R&D collaborative innovation economic performance pharmaceutical industry

Research on the Relationship between Cooperation Innovation Expenditure and Economic Output of China’s pharmaceutical industry

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Asian Journal of Social Pharmacy 2022年第3期17卷 204-213页

作者： Wang Qiuli Chen Yuwen School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To empirically analyze the relationship between cooperation innovation expenditure and economic output of China’s pharmaceutical industry,and provide a reference for improving its economic benefits and the capability of cooperation innovation in the *** The relevant data of China’s pharmaceutical industry from 2000 to 2016 was selected as a *** on the co-integration theory,an error correction model was established to conduct Granger test of causality to study the relationship between cooperation innovation expenditure and economic output of China’s pharmaceutical *** and Conclusion The cooperation innovation expenditure of China’s pharmaceutical industry has a significant positive impact on economic *** cooperation innovation expenditure increases 1%,its economic output will go up by 1.7%.At the same time,the long-term promotion effect of cooperation innovation expenditure on economic output is more significant than the short-term effect.

关键词： pharmaceutical industry cooperation innovation expenditure economic output co-integration test

The Impact of Recent Reforms and Determinants of pharmaceutical industry Patent Application in China

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The Impact of Recent Reforms and Determinants of Pharmaceuti...

作者： Felix Andres Conde Chaux 上海交通大学

学位级别：硕士

China`s State Intellectual Property Office in 2015 became the first office to receive over a million patent applications in a single *** office received almost as many applications as the leaders in IP area combined(Japan,the Republic of Korea and U.S.).On the other hand,China`s pharmaceutical market became the world 2nd(regarding industry value),coming from the 9th place,in the period between 2005 to 2016,according to a IMS Health *** on a patent search and literature research,this study carefully analyzes the impact of recent reforms in the patent applications from pharmaceutical industry in China,identifies the principal fields of technology developed,leading inventors and companies patenting products in the country,and a trend in the applications after two major reforms in the patent ***,based on a questionnaire and interviews to 18 companies with operations in China,the study identifies the factors that companies in pharmaceutical industry considered the most important for their IP strategy and patent application;it has been found that(i) partnership(ii) exclusivity and(iii) licensing opportunities are the factors that influence those decisions in the ***,it has been found that companies are satisfied with the IPR system and found it userfriendly,as well as helpful to the industry growth.

关键词： Intellectual Property Patent Law IP strategy pharmaceutical industry

Research on the Relationship between Salary Incentives for R&D Personnel and R&D Investment in China’s pharmaceutical industry

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Asian Journal of Social Pharmacy 2021年第4期16卷 295-304页

作者： Wang Yuzhuo Wang Su Chen Yuwen School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To explore the relationship between salary incentives for R&D personnel and R&D investment in China’s pharmaceutical industry through an empirical analysis so as to propose suggestions for increasing more R&D investment from the perspective of stimulating R&D *** Based on the relevant data of the China’s pharmaceutical industry in the“China High-tech industry Statistical Yearbook”and other data from the National Bureau of Statistics from 1995 to 2018,co-integration tests was used to construct error correction models and Granger causality tests to explore the relationship between R&D personnel salary incentives and R&D *** and Conclusion There is a long-term balanced relationship between the salary level of R&D personnel in China’s pharmaceutical industry and the investment of R&*** the per capita salary of R&D personnel increases by 1 unit,the internal expenditure of R&D investment will increase by 2.2451 *** the short term,the per capita salary of R&D personnel has a slight negative impact on the internal expenditure of R&D *** addition,the salary incentives for R&D personnel have the most significant role in promoting R&D investment after five years of implementation.

关键词： pharmaceutical industry R&D investment salary incentives for R&D personnel cointegration test