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Spatiotemporal cortical plasticity in response to persistent nociception

Spatiotemporal cortical plasticity in response to persistent...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： JunCHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain,Fourth Military Medical University,Xi''an 710038,China 2 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China

＜正＞Pain is composed of multiple dimensions including sensory-discriminative,affective-motivational and cognitive -evaluative *** it has been gradually known that nociceptive information is processed through widelydistributed, hierachically-interconnected neural network,referred to as neuromatrix,in the ***,the knowledge of pain perception,emotion and cognition at cellular and network level is surprisingly poor and requires to be gained by experimental research using multiple approaches at the cerebral *** the other hand,nociception,when persists,may result in comorbidities of pain such as anxiety,loss of sleep,amnesia,depression,*** still lack of effective therapeutic approaches in *** studies on the effects of persistent or chronic pain on cerebral cortical functions and structures are still *** this symposium,I would like to present some update data showing how persistent nociception influences cerebral cortices including somatosensory cortex area 1（SS1）,anterior cingulate cortex（ACC） and hippocampal formation（HF） which are believed to be involved in various functions of the *** using in vivo evoked potential recordings,in vitro multi-electrode-array（8x8 MEA） and whole-cell patch-clamp recordings on acutely prepared brain slices of rats suffering from persistent nociception,synaptic responses were significantly enhanced not only temporally （LTP-like） but also spatially（network enlargement） in SS 1 and HF,however in ACC,spatial enlargement of synaptic connections were observed,but LTP-like phenomenon was not significantly ***,the altered synaptic connections and functions at the cerebral levels were demonstrated to be caused by peripheral persistent nociception because blockade of impulses in the periphery could eliminate the cerebral changes *** single synaptic level, it was further shown that imbalance between excitatory（EAA） and inhibitory（IAA） amino acids at pre-synaptic components an

关键词： persistent nociception pain perception cortical plasticity

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Imbalance between excitatory and inhibitory synaptic transmission is associated with persistent pain-induced spatial plasticity in the anterior cingulate cortex

Imbalance between excitatory and inhibitory synaptic transmi...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Fa-Le CAO~1,Ying HE~2,Ke-Rui GONG~2,Yan WANG~1,Dong-Liang YUAN~1,Xue-Feng CHEN~1,Rui-Rui WANG~1,Jun CHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi''an 710038,China 2 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China

＜正＞Objective There is substantial evidence supporting the notion that the anterior cingulate cortex（ACC） is an important limbic structure involved in the affective-emotional component of ***,neuronal and synaptic plasticity occurring within the ACC after injury has been proposed to contribute substantially to the pathophysiogenesis of chronic ***,fewer reports have been conducted to investigate simultaneously spatial and temporal features of synaptic plasticity in the ACC in response to persistent pain at cellular and network *** present study was thus undertaken to evaluate,at the local network level,potential changes in synaptic connection and transmission in the ACC following peripheral persistent nociception in *** and Results An initial probe of underlying mechanisms was also attempted at the cellular *** using multi-electrode array recording coupled with two-dimensional current source density imaging,we found that persistent pain produced enlargement of synaptic connection size in the ACC slices, reflecting increased spatial plasticity by pain,with the temporal plasticity,namely long-term potentiation,being unaffected. Further slice patch clamp recordings on identified ACC neurons demonstrated enhancement of excitatory and impairment of inhibitory synaptic transmission following peripheral persistent nociception,leading to imbalance between the two counterparts in the *** of pre-synaptic components is likely to be responsible for the increased excitatory synaptic drive,while both pre- and post-synaptic alterations account for the loss of *** The present study reveals a unique scenario of enhanced spatial plasticity,but not temporal plasticity,in the ACC area following persistent painful experience,reflecting complexity of brain dysfunction caused by the persistence of painful *** addition,we proposed that disruption of the excitatory-inhibitory balance at the supraspinal/cortical

关键词： persistent nociception anterior cingulate cortex synaptic plasticity multi-electrode array recording slice patch clamp recording

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Altered locomotor and exploratory behaviors of rats caused by subcutaneous bee venom injection:open field test

Altered locomotor and exploratory behaviors of rats caused b...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Dan LU~1,Jun CHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China 2 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi''an 710038,China

＜正＞Background:Pain is usually considered to be a complex phenomenon,which requires the scoring of several behavioral *** pathological state,persistent or chronic pain can affect various higher brain functions and lead to emotional *** open field test is usually used to study the emotional state,the effect of various pharmacological agents,biological/physical environmental factors,and the impact of chronic pain on emotional ***,the spontaneous behavioral responses induced by peripheral persistent inflammatory pain in the open field were rarely ***:In this report,we investigated the altered behavioral responses induced by hind-paw bee venom（BV） injection and the relationship between pain-related behaviors and spontaneous responses in the open ***:Male Sprague-Dawley albino rats were randomly divided into four groups:naive,saline,BV-inflamed,bupivacaine-pretreated BV-inflamed *** the open field test,the spontaneous behavioral responses of the rats in these four groups were clearly and long-term ***: It was found that BV-induced persistent nociception can reduce the locomotor and exploratory behavioral responses. The BV-inflamed group also has a significantly increased traveled distance in four corners and decreased traveled distance in center and four *** addition,these altered spontaneous pain-related responses in open field can be reversed by ***:We demonstrated that bee venom induced persistent nociception can elicit alteration of spontaneous behavioral responses in open field which is relevant to pain-related behavior directly.

关键词： open field test spontaneous behavioral responses persistent nociception bee venom test

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Antinociceptive effects of rapamycin on nociception and pain hypersensitivity:roles of mTOR signaling pathway?

Antinociceptive effects of rapamycin on nociception and pain...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Dan LV~1,Yan WANG~2,Chun-Li LI~2,Fan YANG~2,Jun CHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China 2 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi''an 710038,China

＜正＞Objective Mammalian target of rapamycin（mTOR） is a key regulator of mRNA translation which can be modified in a wide range of pathological *** studies indicated that mTOR was likely to be involved in the pathological process of pain hypersensitivity and neuronal *** the present report,we evaluate whether rapamycin is effective in antinociception and anti-hyperalgesia or anti-allodynia caused by subcutaneous injection of whole bee venom（BV）.Methods Rapamycin,a mTOR inhibitor,was administrered by intrathecal（i.t.） administration and intraplantar（***.） administration in conscious *** behavioral tests,persistent spontaneous nociceptive reflex was quantified by counting the number of paw flinches,heat hyperalgesia was quantified by measuring paw withdrawal thermal latency（PWTL） to radiant heat and mechanical hyperalgesia was quantified by measuring paw withdrawal threshold （PWMT） to von Frey *** *** of rapamycin（0.125,1.25 and 12.5μg） resulted in a doserelated suppression of the BV-induced persistent paw flinches,heat hypersensitivity,and mirror-image heat（MIH） hypersensitivity,but without any effectiveness on mechanical ***,*** of rapamycin （0.125,1.25 and 12.5μg） resulted in a dose-related suppression of the BV-induced persistent paw flinches,heat hypersensitivity,and mirror-image heat（MIH） hypersensitivity,but without any effectiveness on mechanical *** mTOR signaling pathway might be involved in pathophysiological processing associated with BV-induced nociception and inflammatory pain at both spinal and peripheral levels.

关键词： mammalian target of rapamycin(mTOR) persistent nociception pain hypersensitivity bee venom test

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nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats

Nociception-induced spatial and temporal plasticity of synap...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ming-Gang LIU~1,Xiao-Yan ZHAO~1,Yan WANG~2,Dong-Liang YUAN~2,Xue-Feng CHEN2,Rui-Rui WANG~2,Jun CHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China 2 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi''an 710038,China

＜正＞Objective Pain is known to be processed by a complex neural network（neuromatrix） in the *** is hypothesized that under pathological state,persistent or chronic pain can affect various higher brain functions through ascending pathways,leading to co-morbidities or mental disability of ***,so far the influences of pathological pain on the higher brain functions are less clear and this may hinder the advances in pain *** In the current study,by virtue of a well-developed multi-electrode array technique,we established an in vitro ’neural network’ model for studying spatiotemporal plasticity of synaptic connection and function in the hippocampal formation（HF） in response to persistent *** waveform of the field excitatory postsynaptic potential（fEPSP）,induced by perforant path electrical stimulation and pharmacologically identified as being activity-dependent and mediated by ionotropic glutamate receptors,was consistently positive-going in the dentate gyrus（DG）,while that in the CA1 was negative-going in shape in naive and saline control *** For the spatial characteristics of synaptic plasticity,persistent pain significantly increased the number of detectable fEPSP in both DG and CA1 areas at the network level and distinctly enhanced the input-output function of individual synaptic efficacy at the cellular *** the temporal plasticity,long-term potentiation produced by theta burst stimulation conditioning was also remarkably enhanced by ***,it is strikingly noted that the shape of fEPSP waveform was drastically deformed or split by the conditioning stimulus under the condition of persistent nociception,while that in naive or saline control state was not *** these changes in synaptic connection and function were further confirmed by the 2-dimentional current source density *** an initial step in dissecting the mechanisms underlying this phenomenon,we performed infrared differential interferen

关键词： persistent nociception hippocampal formation perforant path synaptic plasticity multi-electrode-array

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