Antinociceptive effects of rapamycin on nociception and pain hypersensitivity:roles of mTOR signaling pathway?
会议名称：《中国神经科学学会第四次会员代表大会暨第八届全国学术会议》
会议日期：2009年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：mammalian target of rapamycin(mTOR) persistent nociception pain hypersensitivity bee venom test
摘 要：正Objective Mammalian target of rapamycin（mTOR） is a key regulator of mRNA translation which can be modified in a wide range of pathological *** studies indicated that mTOR was likely to be involved in the pathological process of pain hypersensitivity and neuronal *** the present report,we evaluate whether rapamycin is effective in antinociception and anti-hyperalgesia or anti-allodynia caused by subcutaneous injection of whole bee venom（BV）.Methods Rapamycin,a mTOR inhibitor,was administrered by intrathecal（i.t.） administration and intraplantar（***.） administration in conscious *** behavioral tests,persistent spontaneous nociceptive reflex was quantified by counting the number of paw flinches,heat hyperalgesia was quantified by measuring paw withdrawal thermal latency（PWTL） to radiant heat and mechanical hyperalgesia was quantified by measuring paw withdrawal threshold （PWMT） to von Frey *** *** of rapamycin（0.125,1.25 and 12.5μg） resulted in a doserelated suppression of the BV-induced persistent paw flinches,heat hypersensitivity,and mirror-image heat（MIH） hypersensitivity,but without any effectiveness on mechanical ***,*** of rapamycin （0.125,1.25 and 12.5μg） resulted in a dose-related suppression of the BV-induced persistent paw flinches,heat hypersensitivity,and mirror-image heat（MIH） hypersensitivity,but without any effectiveness on mechanical *** mTOR signaling pathway might be involved in pathophysiological processing associated with BV-induced nociception and inflammatory pain at both spinal and peripheral levels.