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Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population

World Journal of Clinical Cases 2021年第31期9卷 9431-9439页

作者： Hao-Lei Cai Yu-Ling Tong Department of Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina International Healthcare Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Atrophic gastritis is a precancerous lesion of the *** has been reported that pepsinogen(PG)can reflect the morphology and function of the gastric mucosa,and it is therefore used as a marker for the early diagnosis of atrophic *** To evaluate the diagnostic value of serum PG for degree of gastric mucosal atrophy in asymptomatic Chinese upon physical *** Medical data were collected from subjects who underwent transnasal gastroscopy between October 2016 and October *** each study subject,serum PG levels and presence of Helicobacter pylori(***)infection were *** was evaluated using the Operative Link for Gastritis Assessment(OLGA)classification and Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)*** statistical analyses were carried out using SPSS statistical *** A total of 2256 subjects were enrolled and 1922 cases were finally included in the *** on the OLGA grading system,the levels of PGI were slightly decreased,while those of PGII were slightly *** PGI/PGII ratio(PGR)was reduced with increasing *** association between PG and OLGA grading was higher compared with that between PG and the OLGIM grading *** with the OLGA-0 group,a statistically significant difference was observed in the mean age of OLGA-Ⅰ,Ⅲ,and Ⅳ groups(P<0.05).In the ***-positive subjects,the PGR levels were notably lower in the OLGA-Ⅰ,Ⅱ,and Ⅲ groups compared with the OLGA-0 group(P<0.05).***-positive subjects exhibited significantly higher PGI and PGII serum levels and a significantly lower PGR compared with ***-negative patients in different OLGA groups(P<0.05).CONCLUSION Serum PG levels may represent a non-invasive screening marker for gastric mucosal atrophy in asymptomatic subjects.

关键词： pepsinogen Helicobacter pylori Operative Link for Gastritis Assessment Atrophic gastritis Gastric mucosal atrophy Biomarker

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The ontogeny of acidic digestive tract in larval turbot Scophthalmus maximus based on H+/K+-ATPase and pepsinogen

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Journal of Oceanology and Limnology 2023年第3期41卷 1100-1108页

作者： Yanfeng WANG Shulan LIU Teng GUO Shihong XU Qinghua LIU Zhizhong XIAO Daoyuan MA Jun LI Liang CHI Key Laboratory of Experimental Marine Biology Centre for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Qingdao Agricultural University Qingdao 266109China Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China Conson Oriental(Yantai)Recirculating Aquaculture Technology Co. Ltd.Yantai 264000China

Acidic digestion is an important digestive process of marine *** fish stomach,two enzymes are involved in the secretion of hydrochloric acid(HCl)and proteomic digestion:H^(+)/K^(+)-ATPase and ***,the starting of digestive function in fish is still *** reveal the details of acidic digestion of turbot Scophthalmus maximus in early development,a 40 day of turbot larvae culture was *** H^(+)/K^(+)-ATPase gene from the turbot ***(smH^(+)/K^(+)-ATPase)was identified and *** on our previous discription on pepsinogen of turbot ***,we combined pepsinogen and H^(+)/K^(+)-ATPase and analyzed the mechanism of acidic digestion in *** show that the spatial and temporal expression profiles of H^(+)/K^(+)-ATPase agreed with pepsinogen A and C in turbot,indicating a synergetic action between H^(+)/K^(+)-ATPase and pepsinogen during the acidic digestion *** addition,the turbot juveniles showed a faster growth after the expressions of H^(+)/K^(+)-ATPase gene and pepsinogen gene,demonstrating that pepsin had a higher digestive efficiency,for which a compound diet should be provided to the fish from Day 22 *** study provided a reference for biology research and aquaculture of turbot and other marine fishes.

关键词： turbot Scophthalmus maximus acidic digestion H+/K+-ATPase pepsinogen

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Type Ⅰ and type Ⅱ Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

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World Journal of Gastroenterology 2020年第25期26卷 3673-3685页

作者： Lin Yuan Jun-Bo Zhao Ying-Lei Zhou Ya-Bin Qi Qiong-Ya Guo Hai-Hui Zhang Muhammad Noman Khan Ling Lan Chang-He Jia Yan-Rui Zhang Song-Ze Ding Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou UniversityHenan ProvinceChina Henan Provincial People’s Hospital Henan ProvinceChina Henan University School of Medicine Zhengzhou 450003Henan ProvinceChina

BACKGROUND Type I Helicobacter pylori(***)infection causes severe gastric inflammation and is a predisposing factor for gastric ***,its infection status in stepwise gastric disease progression in this gastric cancer prevalent area has not been evaluated;it is also not known its impact on commonly used epidemiological gastric cancer risk markers such as gastrin-17(G-17)and pepsinogens(PGs)during clinical *** To explore the prevalence of type I and type II *** infection status and their impact on G-17 and PG levels in clinical *** Thirty-five hundred and seventy-two hospital admitted patients with upper gastrointestinal symptoms were examined,and 523 patients were enrolled in this *** infection was confirmed by both 13C-urea breath test and serological *** were divided into non-atrophic gastritis(NAG),nonatrophic gastritis with erosion(NAGE),chronic atrophic gastritis(CAG),peptic ulcers(PU)and gastric cancer(GC)*** serological G-17,PG I and PG II values and PG I/PG II ratio were also *** A total *** infection rate of 3572 examined patients was 75.9%,the infection rate of 523 enrolled patients was 76.9%,among which type I *** infection accounted for 72.4%(291/402)and type II was 27.6%;88.4%of GC patients were *** positive,and 84.2%of them were type I infection,only 11.6%of GC patients were *** *** rates of type I *** in NAG,NAGE,CAG,PU and GC groups were 67.9%,62.7%,79.7%,77.6%and 84.2%,*** infection resulted in significantly higher G-17 and PG II values and decreased PG I/PG II *** types of *** induced higher G-17 level,but type I strain infection resulted in an increased PG II level and decreased PG I/PG II ratio in NAG,NAGE and CAG groups over uninfected *** PG I levels showed no difference among all disease groups and in the presence or absence of ***;in stratified analysis,its level w

关键词： Helicobacter pylori Chronic gastric diseases Gastrin-17 pepsinogen Gastric cancer

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Diagnoses of gastric cancer and other gastric diseases by serum pepsinogen I and Ⅱ levels

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Nuclear Science and Techniques 1998年第3期 20-21页

作者： Xiao Zhi Jian 1, Jiang Meng Jun 1 and Cheng Zhao Ming 2 ( 1State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 2Hospital of Zhenjiang Medical College, Zhenjiang 2120001)

１ＩｎｔｒｏｄｕｃｔｉｏｎＭａｎｙｒｅｃｅｎｔｆｏｒｅｉｇｎａｎｄｄｏｍｅｓｔｉｃｒｅｐｏｒｔｓｓｈｏｗｅｄｔｈｅｈｕｍａｎｓｅｒｕｍｐｅｐｓｉｎｏｇｅｎ（ＰＧ）ｌｅｖｅｌｓｗｅｒｅｖａｌｕａｂｌｅｉｎｔｈｅｄｉａｇ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＭａｎｙｒｅｃｅｎｔｆｏｒｅｉｇｎａｎｄｄｏｍｅｓｔｉｃｒｅｐｏｒｔｓｓｈｏｗｅｄｔｈｅｈｕｍａｎｓｅｒｕｍｐｅｐｓｉｎｏｇｅｎ（ＰＧ）ｌｅｖｅｌｓｗｅｒｅｖａｌｕａｂｌｅｉｎｔｈｅｄｉａｇｎｏｓｉｓｏｆｇａｓｔｒｉｃｄｉｓ...

关键词： pepsinogen Radioimmunoassay Gastric cancer Early diagnosis

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Serum pepsinogen levels and their influencing factors:A population-based study in 6990 Chinese from North China

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World Journal of Gastroenterology 2007年第48期13卷 6562-6567页

作者： Li-Ping Sun Yue-Hua Gong Lan Wang Yuan Yuan Cancer Institute First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China

AIM: To explore the essential characteristics of serum pepsinogen (PG) levels in Chinese people, by analyzing the population-based data on the serum levels of PG Ⅰ and Ⅱ and the PGⅠ/Ⅱ ratio, and their influencing factors in Chinese from North China. METHODS: A total of 6990 subjects, who underwent a gastric cancer screening in North China from 1997 to 2002, were collected in this study. Serum pepsinogen levels were measured by enzyme-linked immunosorbent assay (ELISA). H pylori status was determined by histological examination and H pylori-IgG ELISA. The cut-off point was calculated by using receiving operator characteristics (ROC) curves. Factors linked to serum PG Ⅰ/Ⅱ ratio were identified using a multivariate logistic regression. RESULTS: The serum PGⅠ and PGⅡ levels were significantly higher in males than in females (95.2 μg/L vs 79.7 μg/L, P < 0.01; 12.1 μg/L vs 9.4 μg/L, P < 0.01), PGⅠ/Ⅱ ratio was significantly lower in males than in females (7.9 vs 8.3, P < 0.01). The PG Ⅰ/Ⅱ ratio decreased significantly in the aged groups following the progression of gastric mucosa from normal to non-atrophic and atrophic lesions (10.4, 8.8, and 6.6, respectively). The serum PGⅠand Ⅱ levels were significantly higher in patients with H pylori infection than in those without H pylori infection (88.7 μg/L vs 81.4 μg/L, P < 0.01; 11.4 μg/L vs 8.4 μg/L, P < 0.01), while the PGⅠ/Ⅱ ratio was significantly lower in patients with H pylori infection than in those without H pylori infection (7.7 vs 9.6, P < 0.01). For patients with atrophic lesions, the area under the PGⅠ/Ⅱ ROC curve was 0.622. The best cut-off point for PGⅠ/Ⅱ was 6.9, with a sensitivity of 53.2%, and a specificity of 67.5%. Factors linked to PGⅠ/Ⅱ were sensitive to identified PG using a multinomial logistic regression relying on the following inputs: males (OR: 1.151, 95% CI: 1.042-1.272, P = 0.006), age ≥ 61 years (OR: 1.358, 95% CI: 1.188-1.553, P = 0.000), atrophic lesion (OR: 2.075, 95% CI: 1.870-2.302, P = 0.000)

关键词： pepsinogen Gastric cancer Helicobacter pylori Screening

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Value of serum pepsinogen ratio screening for early gastric cancer and precancerous lesions in Youcheng area

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World Journal of Gastrointestinal Surgery 2024年第12期16卷 3729-3736页

作者： Xue Han Wei Yu Department of General Practice Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina Health Management Center Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina

BACKGROUND The 5-year survival rate of patients with advanced gastric cancer remains extremely low(90%.Consequently,strengthening the screening of patients with EGC and precancerous lesions(PCLs)is *** To identify the value of serum pepsinogen ratio(PGR)screening for EGC and PCLs in the Shengli Oilfield Central *** We first selected 385 patients with gastric lesions in the Youcheng area,deter-mining benign lesions,PCLs,and EGC in 135,123,and 127 cases,respec-tively,based on endoscopy and case *** positive rates of pepsinogen I,pep-sinogen II and Helicobacter pylori(***)in the three groups were detected,and the PGR was ***,we plotted receiver operating charac-teristic curves to analyze the screening value of PGR and ***-positive rates for PCLs and *** PGR expression demonstrated a decreasing trend in patients with benign lesions,PCLs,and EGC successively according to the detection results,whereas the ***-positive rate was notably increased in patients with PCLs and EGC compared to those with benign *** area under the curves(AUCs)of PGR,***,and their combination in differentiating patients with benign lesions from those with PCLs were 0.611,0.582,and 0.689,respectively;PGR,***,and their combination had an AUC of 0.618,0.502,and 0.618 in distinguishing PCL patients from EGC patients,respectively;the AUCs of PGR,***,and their combination in discriminating patients with benign lesions from those with EGC were 0.708,0.581,and 0.750,*** PGR has great screening potential for patients with EGC and PCLs in the Youcheng area,and the screening efficiency is further improved by combining the ***-positive rate.

关键词： pepsinogen pepsinogen ratio Early gastric cancer Precancerous lesions Screening value

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Clinical value of serum pepsinogen levels for the diagnosis of esophageal squamous cell carcinoma

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Oncology and Translational Medicine 2019年第1期5卷 19-24页

作者： D.J.Rivadeneira Hesheng Luo Jingyuan Tian Department of Gastroenterology Renmin Hospital of Wuhan University

Objective pepsinogens have been previously studied as markers of gastric atrophy. The objective of this study was to investigate the clinical significance of the serum levels of pepsinogen(PG) I and II, as well as the pepsinogen I/II ratio(PGR) in the diagnosis of esophageal squamous cell carcinoma. Methods A retrospective data analysis of patients who underwent gastroscopy and PG examination in Renmin Hospital was performed. The subjects were grouped into cancer and healthy control groups, and the differences in the serum levels of PGI and PGII, as well as the PGRs were compared. The receiver operating curve and the area under the curve(AUC) were also compared between the *** A total of 351 Chinese patients were enrolled in the study, 209 with esophageal squamous cell carcinoma and 142 healthy controls. Overall, the levels of PGI(P < 0.0001) and PGII(P = 0.0007), as well as the PGR(P = 0.007) of the cancer group were lower than those of the control group. Male subjects in the cancer group had lower PGI(P < 0.0001), PGII(P < 0.0001), and(P = 0.0138). The subjects < 65 years old in the cancer group showed lower PGI(P < 0.0001), PGII(P = 0.001), and PGR(P = 0.0087).Overall, these results show that the levels of PGI(AUC 0.64) and PGII(AUC 0.60) have a predictive ability for discriminating esophageal carcinoma. Moreover, in males < 65 years old, PGI(AUC 0.73) and PGII(AUC 0.69) also showed to have a predictive ability for discriminating esophageal *** Serum PG levels in patients with esophageal squamous cell carcinoma, especially in males aged < 65 years old, are lower than those in healthy people. PGI and PGII are useful for screening esophageal squamous cell carcinoma.

关键词： pepsinogen esophageal squamous cell carcinoma screening

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Value of gastroscopy combined with serum pepsinogen in the diagnosis of high risk Hp related gastric cancer

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Journal of Hainan Medical University 2018年第2期24卷 44-46页

作者： Lin Liu Rong Lu Ying Chen Wen-Tao Guo Digestive Department of Baoji City Center Hospital Baoji Shaanxi 721008

Objective:To explore the value of Helicobacter pylori antibody (Hp-IgG) and serum pepsinogen (PG) combined with gastroscopy for screening early gastric cancer and precancerous lesions in high-risk groups, so as to provide references for early clinical prevention and ***: A retrospective analysis of our hospital from December 2014 to December 2017 were elderly patients with gastric cancer 304 cases, selected admitted 122 cases of elderly patients with gastric precancerous lesion (divided into superficial gastritis group, 70 cases of chronic atrophic gastritis group 52 cases) and 156 cases to the hospital in healthy volunteers as the control group. The status and the positive rate of Helicobacter pylori 13C urea breath test and compared two groups of patients with infection;using enzyme-linked immunosorbent assay of serum pepsinogen I (PG I), II (PG II) and pepsin Hp-IgG quantitative and qualitative diagnosis of individual and combined diagnostic efficiency and the comparison of three kinds of ***: The four groups were compared, the serum PG level of I from high to low were superficial gastritis group, normal control group, atrophic gastritis group and gastric cancer group, the differences were statistically significant;serum PG II levels from high to low in gastric cancer group and superficial gastritis group. Atrophic gastritis group, normal control group, the differences were statistically significant. Compared with the three groups, the positive rate of Hp-IgG was 90.7% in the gastric cancer group, 45.6% in the superficial gastritis group, 52.5% in the atrophic gastritis group, and the gastric cancer group was higher than that in the precancerous lesion group, but there was no difference between the precancerous lesions group. In terms of diagnostic efficacy, the specificity and sensitivity of Helicobacter pylori combined with pepsinogen were higher than those of the single diagnosis. Conclusion: Hp-IgG and PG combined with gastroscopy in s

关键词： Helicobacter pylori pepsinogen High risk Hp related gastric cancer Gastroscope

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Correlation of serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation of cancer cells in patients with gastric cancer

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Journal of Hainan Medical University 2017年第23期23卷 108-111页

作者： Guo-Xu Feng Jia Cheng Kun-Qing Xing Xi Luo Qin Tan Department of Clinical Laboratory the Fifth People's Hospital of Wanzhou District ChongqingWanzhou DistrictChongqing404020

Objective: To investigate the correlation of serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation of cancer cells in patients with gastric cancer. Methods:Superficial gastritis group (n=247), gastric ulcer group (n=159) and gastric cancer group (n=97) who were pathologically diagnosed by gastroscopy in Chongqing wanzhou district people's hospital of 5 between August 2016 and August 2017 were selected, and the differences in serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content as well as proliferation and apoptosis gene expression in lesion tissue were compared among the three groups. Pearson test was used to evaluate the correlation of pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation activity of cancer cells in patients with gastric cancer. Results: Serum pepsinogenⅠ/Ⅱ ratio and gastrin-17 content in gastric cancer group were lower than those in gastric ulcer group and superficial gastritis group. Proliferation genes EIF5A2, MACF1 and PIK3CD mRNA expression levels in gastric cancer group were higher than those in gastric ulcer group and superficial gastritis group whereas SIRT1 mRNA expression level was lower than that in gastric ulcer group and superficial gastritis group;apoptosis gene Livin mRNA expression level was higher than that in gastric ulcer group and superficial gastritis group whereas Bad and Noxa mRNA expression levels were lower than those in gastric ulcer group and superficial gastritis group;serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content in gastric cancer group were negatively correlated with EIF5A2, MACF1, PIK3CD and Livin mRNA expression levels, and positively correlated with SIRT1, Bad and Noxa mRNA expression levels. Conclusion: The serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content abnormally reduce in patients with gastric cancer, and the specific levels are directly correlated with gastric cancer cell proliferation and apoptosis activity.

关键词： gastric cancer pepsinogen Ⅰ/Ⅱ ratio gastrin-17 malignant molecules

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Purification and characterization of lizard fish pepsinogens and pepsins

Purification and characterization of lizard fish pepsinogens...

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中国海洋生化学术会议

作者： Takeyuki Kanto Kenji Hara Faculty of Fisheries Nagasaki University Nagasaki 852 Japan

Five pepsinogens were identified in lizard fish (Saurida wanieso) stomach and two of them (PG-Ⅰand PG-Ⅱ) were purified to homogeneity by column chromatographies on DEAE-Sephacel, Ultrogel AcA54, DEAE-Sepharose and Poly-L-Lysine Agarose. The molecular weights of the two purified PGs were about 41 kDa. Both pepsinogens were converted into pepsins within a few minutes under pH 2. 5. Corresponding pepsins were also purified by a chromatography on S-Sepharose and their molecular weights were 36 kDa as determined on SDS-PAGE. Optimum pHs of the pepsins were around 3. 5 and optimum temperatures were 45℃using hemoglobin as substrate. Both enzymes showed high sensitivity toward pepstatin A, a specific inhibitor of aspartic proteinases. The N-terminal amino acid sequences of PG-Ⅰand PG-Ⅱas determined to the 16th residue were exactly the same and showed high identity to pepsinogens of other animals.

关键词： lizard fish pepsinogen pepsin purification stomach

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