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Roles of paroxetine and corticosterone on adult mammalian ciliary body cell proliferation

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Chinese Medical Journal 2010年第10期123卷 1305-1310页

作者： WANG Hua LAU Benson WM YAU Suk-yu LI Suk-yee LEUNG Nelson WANG Ning-li TANG Siu-wa LEE Tatia MC SO Kwok-fai Department of Anatomy Li Ka Shing Faculty of Medicine the University of Hong Kong Hong Kong Special Administrative Region China the State Key Laboratory of Brain and Cognitive Sciences the University of Hong Kong Hong Kong Special Administrative Region China Neuropsychology Laboratory the University of Hong Kong Hong Kong Special Administrative Region China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China Joint Laboratory for Brain Function and Health (BFAH) Jinan University and the University of Hong Kong

Background The neurogenesis in retina of adult mammals is generally abolished, and this renders the retina lack of regenerative capacity. Despite this, there is a small population of nestin-positive cells in the ciliary epithelium which retains neurogenic potential. The present study aimed at investigating the effect of two drugs, corticosterone and paroxetine, on the cell proliferation of the ciliary body. Methods Adult Sprague-Dawley rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine treatment for 14 days. Cell proliferation in the ciliary body was quantified using 5-bromo-2-deoxyuridine （BrdU） immunohistochemistry. Co-labelling of BrdU and stem cell marker was used to phenotype the BrdU immunoreactive cells. Results Corticosterone treatment suppressed while paroxetine treatment increased the cell proliferation of the ciliary body. Co-labelling with cell markers revealed that the BrdU positive cells also showed nestin expression but not glial fJbrillary acidic protein （GFAP）. Conclusions The results illustrate that proliferation of retinal progenitor cells situated in ciliary body are subjected to regulation by selective serotonin reuptake Jnhibitors （SSRI） and corticosteroJd, which is similar to our previous findings in neurogenic regions in central nervous system （CNS）. paroxetine treatment could reverse the suppressive effect of corticosterone on ciliary body cell proliferation. This provides information for future investigation of retinal stem cell biology and potential treatment of retinal degenerative diseases.

关键词： paroxetine 5-bromo-2-deoxyuridine corticosterone ciliary body cell proliferation neurogenesis

Improvement in quality of life in depressed patients following verum acupuncture or electroacupuncture plus paroxetine:A randomized controlled study of 157 cases

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Neural Regeneration Research 2012年第27期7卷 2123-2129页

作者： Shenghui Ma Shanshan Qu Yong Huang Junqi Chen Renyong Lin Chongqi Wang Ganlong Li Canghuan Zhao Shenchang Guo Zhangjin Zhang First Clinical Medical College Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Guangzhou Overseas Chinese Hospital Guangzhou 510630Guangdong ProvinceChina Guangdong 999 Brain Hospital Guangzhou 510510Guangdong ProvinceChina School of Chinese Medicine LKS Faculty of Medicinethe University of Hong KongHong Kong Special Administrative Region 999077China

Depressed patients with scores of 17 or more on the 17 items of the Hamilton Depression Rating Scale were treated with the antidepressant drug paroxetine. They also underwent verum acupuncture or electroacupuncture at Baihui （GV20） and Yintang （GV29）. The World Health Organization Quality of Life Scale Brief Version showed a significant increase in the total scores of patients who underwent verum acupuncture and electroacupuncture for 6 weeks compared with those who were given paroxetine only; significantly increased physical domain and social relationship scores in verum acupuncture patients compared with paroxetine only; and significantly elevated psychological domain scores with electroacupuncture compared with paroxetine only. These results indicate that both verum acupuncture and electroacupuncture can improve quality of life in depressed patients undergoing paroxetine treatment,

关键词： acupuncture electroacupuncture depression paroxetine World Health Organization Quality of LifeScale Brief Version quality of life Chinese medicine neural regeneration

paroxetine overdose during pregnancy

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Forensic Sciences Research 2021年第4期6卷 237-239页

作者： Selin Acar Hilal Erol Elif Keskin Arslan Nusret Uysal BarışKaradaş Tijen Kaya Temiz Yusuf Cem Kaplan Faculty of Medicine Department of Pharmacologyizmir Katip celebi UniversityizmirTurkey Terafar(izmir Katip celebi University Teratology information Training and research center)izmirTurkey

paroxetine is a selective serotonin reuptake inhibitor(SSRI)used in the treatment of depression and anxiety *** some epidemiological studies,slightly increased risks of major malformations and cardiac malformations have been reported following paroxetine exposure in the first trimester of ***,such findings have been *** is only one report of any overdose of an SSRI during pregnancy,and that involved *** aim of this case report was to describe the impact of a paroxetine overdose in the first trimester of pregnancy on the health of the foetus.A 21-year-old mother of one child who was pregnant with a second child was prescribed 20 mg/day paroxetine hydrochloride for the treatment of anxiety/*** patient ingested 15 or 1620-mg tablets of paroxetine hydrochloride(300-320 mg)during the 5th week of pregnancy as a suicide *** 15 min of ingestion,she was admitted to hospital and treated for *** evidence of maternal SSRI intoxication was observed after *** patient consulted our teratology information service for further risk assessment regarding possible major congenital malformations following the paroxetine *** were unable to find previous reports of paroxetine overdose during pregnancy in the *** timely administration of the overdose treatment and the lack of maternal intoxication symptoms were considered positive for the foetal well-being,and the patient was referred for perinatology and psychiatry follow-ups.A healthy,3500-g male infant was born at 38 weeks’gestation,and his development at the age of 2 years was *** is the first reported case of paroxetine overdose during *** studies are needed to evaluate pregnancy outcomes after SSRI overdose.

关键词： Forensic sciences forensic toxicology paroxetine overdose teratogenicity case report

The Effect of paroxetine on Depressive Symptom with Somatic Disease and Change of Platelet 5-HT Concentration

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第1期23卷 29-31页

作者：郑凯史庭慧刘晓晴 DepartmentofNeurology TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnology DepartmentofInternalMedicine TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnology

To study the effect of paroxetine on depressive symptom accompanying somatic disease and the value of platelet 5-HT concentration in the diagnosis of depression, 30 patients with depressive symptom were treated with paroxetine. All patients were evaluated on Zung and HAMD scale and assayed of platelet 5-HT concentration before and after treatment. It was found that patients had a lower level of platelet 5-HT concentration than healthy people (P0.05). It was suggested that paroxetine was a good antidepressant and platelet 5-HT concentration was useful in the screening of depression.

关键词： paroxetine depressive symptom 5-HT

Clinical Observation on Treatment of Depression by Electro-Acupuncture Combined with paroxetine

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Chinese Journal of Integrative Medicine 2007年第3期13卷 228-230页

作者：张贵金石湛瑜柳森龚士虎刘继强刘吉善 Department of Psychology Hospital of Traditional Chinese Medicine of Shiyan City

Objective： To observe the clinical efficacy and adverse reactions of paroxetine combined with electro-acupuncture （EA） in treating depression. Methods： Forty-two patients with depression were randomly assigned to the observation group （22 patients） treated with EA combined with paroxetine, and the control group （20 patients） treated with paroxetine alone, and the therapeutic course for both groups was 6 weeks. The therapeutic efficacy and adverse reactions were evaluated with scores by Hamilton depression scale （HAMD） and treatment emergent symptoms scale （TESS）, respectively. Results： HAMD scores determined at the end of the 1st, 2nd, 4th, and 6th week of the treatment course were significantly lower in the observation group than those in the control group （P〈0.05）. The significant improvement rate evaluated at the end of the 6-week treatment was remarkably higher in the observation group than that in the control group （72.7% vs 40.0%）. No significant difference of TESS scores was found between the two groups. Conclusion： EA combined with paroxetine has better clinical efficacy than that of paroxetine alone, with milder adverse reaction and quicker initiation of effect.

关键词： depression paroxetine electro-acupuncture

paroxetine Augments while Naloxone Abolishes the Analgesic Effect of Paracetamol in Acute Nociceptive Pain in Mice

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Pharmacology & Pharmacy 2013年第4期4卷 398-405页

作者： Mohammad Raafat Abdalla Waleed Al Malki Muhammad Ahmed Department of Pharmacology and Toxicology Faculty of Pharmacy Umm Al-Qura University Makkah KSA

The mechanism(s) of analgesic action of paracetamol (acetaminophen;N-acetyl-p-aminophenol) remains controversial. Previous studies on rats suggested that the antinociceptive action of paracetamol might involve the central descending inhibitory pain pathways recruiting both a serotoninergic and an opioidergic system. This study explores this issue in mice using paroxetine, the most potent selective serotonin re-uptake inhibitor, and the nonselective opioid pure antagonist naloxone. Animals were divided into two main groups for two separate experiments, each subdivided into 3 subgroups. In both experiments;the first group served as control, the second group received paracetamol (200 mg/kg, i.p). In one experiment, the third group received paroxetine (20 mg/kg p.o for 7 days) before paracetamol. In the other experiment, animals of the third group were pretreated with naloxone (5 mg/kg, i.p) 30 min before paracetamol. The antinociceptive effect of paracetamol was tested using the hot plate test. Paracetamol displayed a significant antinociceptive activity that was augmented by pretreatment with paroxetine as was shown by maintenance of its effect beyond that shown by paracetamol alone. On the other hand, pretreatment with naloxone abolished paracetamol’s antinociceptive activity in the hot-plate test. These results extended the previous observation in rats that the antinociceptive effect of paracetamol involved activation of a central descending pain inhibitory pathway with serotonin and opioidergic peptides being potential mediators recruited.

关键词： Paracetamol paroxetine Naloxone Mice

paroxetine promotes neural function recovery in ischemic stroke patients without depression

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Paroxetine promotes neural function recovery in ischemic str...

Administration of Zinc with paroxetine Improved the Forced Swim Test Behavioral Pattern of Treated Mice in Acute and Sub-Acute Study

浙江省神经科学学会2015年会暨第七届宁波大学神经科学...

作者： Xiao-Ling Pan Xing Cheng Chuan-Chen Hu Jian-Wei Wang 陈红芳 Department of neurology Jinhua Hospital Affiliated to Zhejiang University

Objective:To investigate the effects of paroxetine on neural function recovery in ischemic stroke patients without ***:167 acute ischemic stroke hospitalized patients without depression were selected and divided into the treatment group and the control group *** patients received the conventional secondary prevention and rehabilitation training of ischemic stroke,the treatment group patients were additionally treated with paroxetine(20mg/d)for 3 months,observed for 6 ***,MoCA and HAMD were used at day 0,day 15,day 90 and day 180(90 days after the treatment stopped) after the start of the study,then we made a comparison about the scores between the two ***:There were statistical differences in the FMMS and MoCA scores between the treatment and control group at day 90 and day 180 after the start of the study(p0.05).There were statistical differences in the HAMD scores between the two groups at day 180(pparoxetine could improve motor and cognitive function recovery in acute ischemic stroke patients without ***,it would reduce the occurrence of depression after stroke.

关键词： paroxetine Ischemic stroke Neural function recovery

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Journal of Behavioral and Brain Science 2015年第7期5卷 213-220页

作者： Hesham El Refaey Hasan S. Al Amri Abdelkader E. Ashour Atallah F. Ahmed Pharmacology Department College of Pharmacy King Khalid University Abha Saudi Arabia Psychiatry Department College of Medicine King Khalid University Abha Saudi Arabia Department of Pharmacology and Toxicology College of Pharmacy King Saud University Abha Saudi Arabia Department of Pharmacognosy College of Pharmacy King Saud University Abha Saudi Arabia

Despite progressive improvement in treating major depressive disorder (MDD), it remains mostly unresponsive to one antidepressant medication. Zinc is a brain highly abundant trace metal, a brain derived neurotrophic factor (BDNF) inducer, a modulator of synaptic plasticity and potent suppressor of the NMDA receptors. We proposed that co-administration of zinc with the antide-pressants may represent a valuable regimen to improve the efficacy of these drugs. This work has been implemented to evaluate the behavioral changes of acute and sub-acute co-administration of zinc with Paroxtine in mice. Methods: The animals were injected intra-peritoneal with either Paroxtine (20 mg/kg) which was a selective serotonin reuptake inhibitor (SSRI), zinc sulfate (30 mg/kg) or Paroxtine in combination with zinc for one day and one week (once daily). The pattern of the animal behavior was assessed in the forced swim test (FST). Results and Discussion: The behavioral patterns of the animals in the FST include immobility, swimming and climbing. Successful antidepressant should decrease the immobility time with either increase in swimming and/or climbing behavior based on the drug pharmacological activity. Our results revealed a significant decrease of immobility and increase of swimming behavior indicating serotonin-dependent pharmacological activity of Paroxtine or zinc alone as well as in the animals treated with zinc in combination with Paroxtine. There was no significant difference in the animals’ behavior between acute and sub-acute treatment with zinc or even upon its addition to paroxetine. Our data support the concept that co-administration of zinc may provide further antidepressant activity. Zinc may offer additional clinical value particularly in geriatric patients or other populations where zinc level has shown dramatic decrease.

关键词： Depression Antidepressants paroxetine Zinc

Rate of social anxiety disorder, its comorbidity with depression and paroxetine effects in outpatients in Japan

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Open Journal of Psychiatry 2013年第1期3卷 191-194页

作者： Yukihiko Shirayama Michio Takahashi Masatoshi Suzuki Atsushi Kimura Koichi Sato Department of Psychiatry Teikyo University Chiba Medical Center Ichihara Japan

The prevalence of persons with social anxiety disorder (SAD) in Japan remains unknown. This study examined 293 patients with age between 20 and 60 at first visit on the outpatient clinic of psychiatry by the section of social phobia of M.I.N.I. and DSM-IV. After that, 10 patients with both SAD out of 16 patients (trial recruited) completed 12 weeks of treatment with paroxetine. Among 63 patients with 4 points and 40 patients with 3 points on the M.I.N.I., 21 patients (33%) and 16 patients (40%) were diagnosed as SAD on DSM-IV criteria, respectively. Together, 37 patients (12.6%) were diagnosed as SAD out of the 293 outpatients. Among 37 patients with SAD, 23 patients (62%) had comorbid depression. As for 10 patients after treatment with paroxetine, 8 patients improved from the point of recovery of depression (HAM-D scores below 10), whereas only 4 patients improved from the point of recovery of social phobia (L-SAS scores below 30). Three points as well as 4 points on the M.I.N.I. is meaningful for the diagnosis of SAD. For a while, paroxetine exerted less beneficial effects on SAD rather than on depression.

关键词： Social Anxiety Disorder Depression paroxetine Comorbidity