检索结果-南通市图书馆

A focus on parietal cells as a renewing cell population

World Journal of Gastroenterology 2010年第5期16卷 538-546页

作者： Sherif M Karam Department of Anatomy Faculty of Medicine and Health Sciences United Arab Emirates University Al-Ain PO Box 17666 United Arab Emirates

The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthymidine radioautography in combination with electron microscopy, it was possible to demonstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem cells anchored in the isthmus region are responsible for the production of parietal cells. The stem cells give rise to three main progenitors: prepit, preneck and preparietal cells. parietal cells develop either directly from the noncycling preparietal cells or less commonly via differentiation of the cycling prepit and preneck cell progenitors. The formation of a parietal cell is a sequential process which involves diminishment of glycocalyx, production of cytoplasmic tubulovesicles, an increase in number and length of microvilli, an increase in number and size of mitochondria, and fi nally, expansion and invagination of the apical membrane with the formation of an intracellular canalicular system. Little is known about the genetic counterparts of these morphological events. However, the time dimension of parietal cell production and the consequences of its alteration on the biological features of the gastric gland are well documented. The production of a new parietal cell takes about 2 d. However, mature parietal cells have a long lifespan during which they migrate bidirectionally while their functional activity for acid secretion gradually diminishes. Following an average lifespan of about 54 d, in mice, old parietal cells undergo degeneration and elimination. Various approaches for genetic alteration of the development of parietal cells have provided evidence in support of their role as governors of the stem/progenitor cell proliferation and differentiation programs. Revealing the dynamic features and the various roles of parietal cells would help

关键词： cell differentiation cell dynamics cell renewal Oxyntic gland Oxyntic mucosa parietal cell Preparietal cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Mica Monomer Powder on Chief and parietal cells as well as G and D cells in Gastric Mucosa of Chronic Atrophic Gastritis in Rats

引用

Chinese Journal of Integrative Medicine 2008年第2期14卷 111-116页

作者：朱方石姒健敏王良静王冬飞陈萍 Academy of Traditional Chinese Medicine of Jiangsu Province Sir Run Run Shaw Clinical Medical Institute Zhejiang University

Objective： To study the regulative action of mica monomer powder preparation on the chief and parietal cells as well as G and D cells in the gastric mucosa of the experimental atrophic gastritis （CAG） rats. Methods： Intervention therapy was given to the experimental CAG rats at three different doses of mica monomer powder preparation to evaluate the changes of chief and parietal cells as well as G and D cells in the gastric mucosa and the histopathological changes of gastric mucosa. Results： Mica monomer powder preparation at three different doses could increase the amount of chief and parietal cells as well as G and D cells in gastric mucosa of the experimental CAG rats and alleviate and control the inflammation of gastric mucosa and the atrophy of gastric mucosa glands. Especially, better effects were shown in the mid and high dose groups. Conclusion： Mica has the pharmacological action of protecting the gastric mucosa, promoting the regeneration of gastric glands, enhancing blood flow of the gastric mucosa, and consequently improving the inflammatory responses of the gastric mucosa. One of the mechanisms is associated with promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism including gut hormone secretion （gastrin and somatostatin） by increasing the number of chief and parietal cells as well as G and D cells.

关键词： mica chronic atrophic gastritis chief cell parietal cell G cell D cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig

引用

Journal of Animal Science and Biotechnology 2021年第3期12卷 1031-1041页

作者： P.Trevisi D.Luise F.Correa S.Messori M.Mazzoni J.P.Lallès P.Bosi Department of Agricultural and Food Sciences University of BolognaViale G.Fanin 4640127 BolognaItaly Present Address:World Organisation for Animal Health(OIE) Scientific Secretariat for the STAR-IDAZ International Research Consortium on animal health12 rue de Prony75017 ParisFrance Department of Veterinary Sciences University of BolognaVia Tolara di SopraOzzano nell’Emilia(BO)BolognaItaly INRAE Human Nutrition DivisionSite of Theix63122 Saint-Genès-ChampanelleFrance

Background:Scarce is knowledge on the process regulating the development of acid secretion,orexigenic signaling,and chemosensing in the stomach of young *** of early microbial encounters by suckling pigs can interact with the gut maturation,by the induction of different molecular *** goal was to assess if the age of offspring and the maternal environment,influenced by sow antibiotic treatment peripartum,could affect gastric morphology and the expression of genes involved in the control of hydrochloric secretion,feed intake,taste,and inflammation in offspring ***:84 pigs from sows fed a diet with amoxicillin(on-d10 to+d21 from farrowing,ANT)or without(CON)were sacrificed at d14,d21,d28(weaning)or *** of oxyntic(OXY),pyloric(PY)and cardiac mucosae close to OXY were collected and parietal and enteroendocrine cells(EECs)were *** gene expression of a set of 11 key genes(ATP4A,SSTR2,GAST,GHRL,MBOAT4,PCSK1,GNAT1,TAS1R1,TAS1R3,IL8 and TNF)was assessed by *** addition,40 offspring obtained from the same ANT and CON sows were offered a normal or a fatenriched diet for 4 weeks between 140 and 169 d of age,and then OXY and PY were ***:The number of parietal and EECs increased with age(P<0.001).ATP4A increased with age(within suckling,P=0.043,post-weaning ***,P<0.001),SSTR2 increased only after weaning(P<0.001).In OXY,GHRL increased during suckling(P=0.012),and post-weaning as a trend(P=0.088).MBOAT4 tended to increase during suckling(P=0.062).TAS1R1 increased from suckling to post-weaning period(P=0.001)and was lower in ANT offspring(P=0.013).GNAT1 in PY was higher in ANT offspring(P=0.041).Antibiotic treatment of sows peripartum increased expression of GHRL and MBOAT4 in OXY of growing-finishing offspring aged 5 ***:Data show that sensing for umami taste and ghrelin regulation can be affected by maternal environment,but the development of acid secretion,orexigenic signaling and taste

关键词： Enteroendocrine cell Gastrin Ghrelin parietal cell Stomach Taste receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dysregulation of gastric H,K-ATPase by cigarette smoke extract

引用

World Journal of Gastroenterology 2009年第32期15卷 4016-4022页

作者： Muna Hammadi Mohamed Adi Rony John Ghalia AK Khoder Sherif M Karam Department of Anatomy Faculty of Medicine & Health SciencesUAE UniversityAl-AinPO Box 17666United Arab Emirates

AIM:To test whether the expression and activity of H,K-ATPase in parietal cells would be affected by cigarette smoke ***: Extracts of cigarette smoke were administered into mice by gastric gavage (5 mg/kg body weight/day) for 3 d or in drinking water for 7 or 14 d. For the latter, each day a mouse consumed 5 mL water containing extracts of two cigarettes, on average. Control littermate mice received only vehicle. To compare the amount of H,K-ATPase in control and smoke-treated mice, the stomach was processed for Western blotting and immunohistochemical analysis using monoclonal antibodies specific for α- or β-subunits of H,K-ATPase. The p-nitrophenylphospatase activity assay was used as a measurement for K-dependent H,K-ATPase ***: Probed transblots showed an increase in the amount of H,K-ATPase in smoke-treated mice which was confirmed by immunohistochemistry and was found to be due to increased amounts of protein per parietal cell rather than an increased parietal cell number. The increase in the amount of H,K-ATPase was associated with an enhancement of its enzymatic activity. K-dependent activity in control and smoke-treated mice was significantly different (respectively, 0.12 μmol/mg vs 0.27 μmol/mg per minute, P<0.05).CONCLUSION: Administration of cigarette smoke extract is associated with an increase in the amount and activity of H,K-ATPase and hence, smokers are susceptible to development of peptic ulcer.

关键词： Proton pump H,K-ATPase parietal cell Gastric gland Oxyntic mucosa Cigarette smoke extract Smoking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of potassium in acid secretion

引用

World Journal of Gastroenterology 2005年第34期11卷 5259-5265页

作者： John P Geibel Professor of Surgery and cellular and Molecular Physiology Director of Surgical Research Yale University School of Medicine CT United States

Potassium (K+) ions are critical for the activation and catalytic cycle of the gastric H+,K+-ATPase, resulting in the secretion of hydrochloric acid into the parietal cell canaliculus. As both symptom, severity and esophageal mucosal damage in gastro-esophageal reflux disease (GERD) are related to the degree of acid exposure, K+ is a logical target for approaches to inhibit acid *** probable K+ binding site on the gastric H+,K+-ATPase has recently been described and studies are elucidating how K+ activates the enzyme. K+ channels in the apical membrane of the parietal cell are implicated in the recycling of K+ and, to date, three potential K+ channels (KCNQ1, Kir2.1 and Kir4.1) have been identified. The channels represent theoretical sites for agents to control acid secretion but it will be difficult to develop selective blockers. An alternative strategy is to prevent K+ from activating gastric H+,K+-ATPase; the potassiumcompetitive acid blocker (P-CAB) class inhibits acidsecretion by binding at or near the K+ binding *** research is further defining the role of K+ in the functioning of the gastric H+,K+-ATPase, as well as determining the clinical utility of agents directed toward this important cation.

关键词： Gastric H%+,K^+-ATPase HCl parietal cell Potassium Potassium channel Potassium channel blocker Potassium-competitive acid blocker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis

引用

World Journal of Gastrointestinal Pathophysiology 2010年第5期1卷 154-165页

作者： Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L Merchant Departments of Internal Medicine-Gastroenterology University of Michigan Department of Molecular and cellular Physiology University of Cincinnati Department of Surgery Austin and Repatriation Medical CenterUniversity of Melbourne Departments of Internal Medicine and Molecular and Integrative Physiology University of Michigan

AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in ***:Helicobacter felis(***)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 *** treatment,mice were analyzed for morphological changes and gastric acid *** RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of *** ***, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented ***-induced inflammation and *** to the uninfected controls,infected mice also had significantly decreased gastric *** eradication of *** with THIO treatment,gastric acidity was *** to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during *** elevated gastric acid levels, after eradication of *** with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was *** revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during *** infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R *** stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin.

关键词： Gastrin Somatostatin Histamine parietal cell Helicobacter felis Nα-methylhistamine Rα-methylhistamine Thioperamide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：