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The Effect of Tuberculosis Infection on pancreatic Beta-cell function in Patients with Type 2 Diabetes Mellitus

Advances in Bioscience and Biotechnology 2024年第2期15卷 129-139页

作者： Mengdan Kong Ailin Zhong Shilin Qu Junli Xue Department of Endocrinology Jingzhou Hospital Affiliated to Changjiang University Jingzhou China Department of Tuberculosis The First People’s Hospital of Jingzhou City Jingzhou China Department of Endocrinology The Third People’s Hospital of Jingzhou City Jingzhou China

Objective: The aim of this study is to investigate how individuals with type 2 diabetes mellitus’ pancreatic β-cell function index and insulin resistance index are affected by tuberculosis infection. Methods: The study group consisted of 89 patients with type 2 diabetes mellitus and tuberculosis infection who were admitted to Jingzhou Chest Hospital between March 2019 and March 2021. Gender and duration of diabetes were matching conditions. The control group was made up of 89 patients with type 2 diabetes who were admitted to Jingzhou Central Hospital’s endocrinology department during the same period. The two patient groups provided general information such as gender, age, length of diabetes, and blood biochemical indexes such as glycosylated hemoglobin (HbA1c), fasting glucose (FPG), and fasting C-peptide (FC-P). The HOMA calculator was used to calculate the HOMA-β and the HOMA-IR, and intergroup comparisons and correlation analyses were carried out. Results: Regarding gender, age, disease duration, FC-P, and HbA1c, the differences between the two groups were not statistically significant (P > 0.05). However, BMI, FPG, HOMA-β, and HOMA-IR showed statistically significant differences (P 0.05) and HbA1c. Conclusions: In type 2 diabetes mellitus combined with tuberculosis infection, the patients had higher FPG levels and lower FC-P levels, the secretory function of pancreatic β-cells was more severely impaired, and insulin resistance was more obvious.

关键词： Tuberculosis Infection Type 2 Diabetes Mellitus pancreatic β-cell function Insulin Resistance

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Obstructive sleep apnea is associated with impaired glucose metabolism in Han Chinese subjects

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Chinese Medical Journal 2013年第1期126卷 5-10页

作者： GU Chen-juan LI Min LI Qing-yun LI Ning SHI Guo-chao WAN Huan-ying Department of Respiratory Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of Medicine Shanghai200025 China

Background Increasingly, evidence from population, clinic-based and laboratory studies supports an independent association between obstructive sleep apnea syndrome （OSAS） and an increased risk of type 2 diabetes; however, this observation has yet to be replicated in China and the potential mechanisms that link these two conditions are not clear. Methods A total of 179 Han Chinese subjects were enrolled in this study. All subjects underwent polysomnography, the oral glucose tolerance-insulin releasing test （OGTT-IRT） and serum HbAlc measurement. Indexes including homeostasis model assessment-IR （HOMA-IR）, Matsuda index, HOMA-β, early phase insulinogenic index （△I30 / △G30）, AUC-I180 and oral disposition index （DIo） were calculated for the assessment of insulin resistance and pancreatic β-cell function. Results Based on OGTT, 25.4%, 44.6% and 54.5% subjects were diagnosed having glucose metabolic disorders respectively in control, mild to moderate and severe OSAS groups （P 〈0.05）. Serum HbA1c levels were highest in subjects with severe OSAS （P 〈0.05）. In contrast, compared with normal subjects, HOMA-β, △I30/△G30 and DIo were lower in severe OSAS group （P 〈0.05）. In stepwise multiple linear regressions, 0-min glucose and HbAlc were positively correlated with the percentage of total sleep time below an oxyhemoglobin saturation of 90% （T90）（Beta = 0.215 and 0.368, P 〈0.05）; 30-min and 60-min glucose was negatively correlated with the lowest SpO2 （LSpO2）（Beta = -0.214 and -0.241, P 〈0.05）. HOMA-β and Dlowere negatively correlated with T90 （Beta = -0.153 and -0.169, P 〈0.05） while body mass index （BMI） was the only determinant of HOMA-IR and Matsuda index. Conclusions OSAS is associated with impairment in glucose tolerance and pancreatic β-cell function in Han Chinese subjects while insulin sensitivity is mainly determined by obesity.

关键词： obstructive sleep apnea glucose metabolism pancreatic β-cell function insulin resistance

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