Obstructive sleep apnea is associated with impaired glucose metabolism in Han Chinese subjects

作     者：GU Chen-juan LI Min LI Qing-yun LI Ning SHI Guo-chao WAN Huan-ying 

作者机构：Department of Respiratory Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of Medicine Shanghai200025 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第1期

页      面：5-10页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 10[医学] 

基　　金：The current study was supported by the Key Basic Research Program of Shanghai Science and Technology Commission (No.11JC1411302) 

主　　题：obstructive sleep apnea glucose metabolism pancreatic β-cell function insulin resistance 

摘      要：Background Increasingly, evidence from population, clinic-based and laboratory studies supports an independent association between obstructive sleep apnea syndrome （OSAS） and an increased risk of type 2 diabetes; however, this observation has yet to be replicated in China and the potential mechanisms that link these two conditions are not clear. Methods A total of 179 Han Chinese subjects were enrolled in this study. All subjects underwent polysomnography, the oral glucose tolerance-insulin releasing test （OGTT-IRT） and serum HbAlc measurement. Indexes including homeostasis model assessment-IR （HOMA-IR）, Matsuda index, HOMA-β, early phase insulinogenic index （△I30 / △G30）, AUC-I180 and oral disposition index （DIo） were calculated for the assessment of insulin resistance and pancreatic β-cell function. Results Based on OGTT, 25.4%, 44.6% and 54.5% subjects were diagnosed having glucose metabolic disorders respectively in control, mild to moderate and severe OSAS groups （P 〈0.05）. Serum HbA1c levels were highest in subjects with severe OSAS （P 〈0.05）. In contrast, compared with normal subjects, HOMA-β, △I30/△G30 and DIo were lower in severe OSAS group （P 〈0.05）. In stepwise multiple linear regressions, 0-min glucose and HbAlc were positively correlated with the percentage of total sleep time below an oxyhemoglobin saturation of 90% （T90） （Beta = 0.215 and 0.368, P 〈0.05）; 30-min and 60-min glucose was negatively correlated with the lowest SpO2 （LSpO2） （Beta = -0.214 and -0.241, P 〈0.05）. HOMA-β and Dlowere negatively correlated with T90 （Beta = -0.153 and -0.169, P 〈0.05） while body mass index （BMI） was the only determinant of HOMA-IR and Matsuda index. Conclusions OSAS is associated with impairment in glucose tolerance and pancreatic β-cell function in Han Chinese subjects while insulin sensitivity is mainly determined by obesity.