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ph-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

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Nano Research 2019年第1期12卷 49-55页

作者： Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing Division of Chemistry and Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637459Singapore School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable ***,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and ***,we in troduce a new class of ph-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to ph change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(*** ph5)in mice with higher signal-to-noise *** CTN is biodegradable under physiological conditions(*** 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in *** results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng ph-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.

关键词： charge-transfer nanocomplex second near-infrared window photoacoustic imaging ph-sensitive biodegradable tumor acidic microenvironment

ph-sensitive KHA/CMC-Fe^(3+)@CS hydrogel loading and the drug release properties of riboflavin

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Particuology 2024年第3期86卷 13-23页

作者： Jie Song Xi Li Yuhua Niu Lijun Chen Zhiqiang Wei Yidan Li Youqian Wang Shaanxi University of Science&Technology Xi'an710021China

To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball *** tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal *** stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were *** results showed that the hydrogel spheres were significantly ph-sensitive,with 11.16 g/g higher swelling in an alkaline environment(ph=7.4)than that in an acidic environment(ph=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

关键词： Potassium humate Hydrogel spheres ph-sensitive Drugsustained-release Drug release model

ph-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy

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Acta pharmaceutica Sinica B 2021年第2期11卷 520-533页

作者： Zhiming Zhangy Chenlu Huangy Li Zhang Qing Guo Yu Qin Fan Fan Boxuan Li Bao Xiao Dunwan Zhu Linhua Zhang Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Chemotherapy has been a major option in clinic treatment of malignant ***,single chemotherapy faces some drawbacks,such as multidrug resistance,severe side effects,which hinder its clinic application in tumor *** nanoparticles loading with chemotherapeutic agent and photosensitizer could be a promising way to efficiently conduct tumor combination *** the current study,a novel ph-sensitive and bubble-generating mesoporous silica-based drug delivery system(denoted as M(a)D@PI-PEG-RGD)was *** bicarbonate(NH4 HCO3;abc)and chemotherapeutic agent doxorubicin(DOX)were loaded into the pores of mesoporous *** green(ICG)as a photothermal and photodynamic agent was loaded onto the polydopamine(PDA)layer *** synthesized nanoparticles displayed a narrow polydispersity(PDI)and small particle size as characterized through dynamic light scattering-autosizer *** nanoparticles also showed high targeting efficacy through RGD modification as indicated by cellular uptake and animal *** release analysis confirmed that the nanoparticles were ph-dependent and that NH4 HCO3 accelerated drug *** the same time,the nanoparticles had obvious photothermal and photodynamic effects performed by ICG which restrained tumor growth *** summary,the multifunctional nanoparticles presented a promising system for combination therapy.

关键词： Mesoporous silica ph-sensitive Bubble-generating Targeting modification Combination therapy

NOVEL ph-sensitive DRUG DELIVERY SYSTEM BASED ON NATURAL POLYSACCHARIDE FOR DOXORUBICIN RELEASE

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Chinese Journal of Polymer Science 2008年第3期26卷 369-374页

作者：樊渝江 National Engineering Research Center for Biomaterials Engineering Research Center of BiomaterialsSichuan UniversityChengdu 610064China

A novel ph-sensitive nanoparticle drug delivery system (DDS) derived fl om natural polysaccharide pullulan for doxorubicin (DOX) release was *** was functionalized by successive carboxymethylization and amidation to introduce hydrazide *** was then grafted onto pullulan backbone through the ph-sensitive hydrazone bond to form a pullulan/DOX *** conjugate self-assembled to form nano-sized particles in aqueous solution as a result of the hydrophobic interaction of the ***...

关键词： Natural polysaccharide ph-sensitive Nanoparticle drug delivery system Doxorubicin

Encapsulating maytansinoid in ph-sensitive nanocarriers:The importance of using extremely potent cytotoxic agents and fast release for nanomedicine to achieve tumor elimination

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Nano Research 2019年第8期12卷 1959-1966页

作者： Bo Dai Xingyu Wu Christopher J. Butch Jianquan Wang Ziyang Wang Yisheng Wang Shuming Nie Qian Lu Yiqing Wang Yitao Ding Drum Tower Clinical Medical College Nanjing Medical UniversityNanjing 210008China Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing UniversityNanjing 210008China Department of Biomedical Engineering University of Illinois at Urbana-ChampaignIllinois 61801USA

The clinical translation of nanomedicine is hindered by the low delivery efficiency, and consequently drug concentration in tumor sites falls short of the therapeutic effective range which leads to poor clinical outcomes. One important lesson learned from the development of antibody-drug-conjugates (ADCs) is that to achieve significant clinical benefits, extremely potent cytotoxic agents and cleavable linkers should be used. By encapsulating maytansinoid, AP3, which is 100-1,000 times more potent than most conventional small molecule anticancer drugs, in ph-sensitive acetalated dextran-polyethylene glycol (PEG)(ADP) nanocarriers, even with only 1% drug loading, we were able to eradicate tumors in 50% of tested animals with negligible side effects, while free AP3 only showed marginal efficacy and severe liver damages. This study suggests that besides improving the low efficiency of nano-delivery systems, the potency of drug to be delivered is also critical to the clinical outcomes of nanomedicine. Our results also showed that ADP nanoparticles (NPs) were able to expand the narrow therapeutic window of maytansinoids in a similar manner to the ADCs.

关键词： nanomedicine drug delivery maytansinoid extremely potent drug ph-sensitive nanocarrier

Preparation and functional study of ph-sensitive amorphous calcium phosphate nanocarriers

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Chinese Journal of Chemical Engineering 2022年第8期35卷 244-252页

作者： Baolong Niu Min Li Jianhong Jia Lixuan Ren Xin Gang Bin Nie Yanying Fan Xiaojie Lian Wenfeng Li College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024China Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength&Structural Impact Institute of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030001China

Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor *** this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting ***-FCNs/ACP shows an ability to load curcumin(Cur)with ph-sensitive responsive drug release behavior and excellent ***-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in *** prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer ***,the as-prepared nanoparticles have promising applications in treating tumor disease.

关键词： Hyaluronic acid Amorphous calcium phosphate Fluorescent carbon nanoparticles ph-sensitive Tumor targeting

Microneedle-array patch with ph-sensitive formulation for glucoseresponsive insulin delivery

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Nano Research 2021年第8期14卷 2689-2696页

作者： Feng-Qin Luo Guojun Chen Wei Xu Daojia Zhou Jia-Xian Li Yong-Cong Huang Run Lin Zhen Gu Jin-Zhi Du Guangzhou First People’s Hospital and Institutes for Life SciencesSchool of MedicineSouth China University of TechnologyGuangzhou 510006China Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095-1413USA School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of TechnologyGuangzhou 510006China Department of Radiology the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China National Engineering Research Center for Tissue Restoration and Reconstruction Key Laboratory of Biomedical Materials and Engineering of the Ministry of EducationKey Laboratory of Biomedical Engineering of Guangdong ProvinceInnovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China College of pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China

Glucose-responsive insulin delivery systems show great promise to improve therapeutic outcomes and quality of life for people with ***,a new microneedle-array patch containing ph-sensitive insulin-loaded nanoparticles(NPs)(SNP(I))together with glucose oxidase(GOx)-and catalase(CAT)-loaded ph-insensitive NPs(iSNP(G+C))is constructed for transcutaneous glucose-responsive insulin ***(I)are prepared via double emulsion from a ph-sensitive amphiphilic block copolymer,and undergo rapid dissociation to promote insulin release at a mild acidic environment induced by GOx in iSNP(G+C)under hyperglycemic *** in iSNP(G+C)can further consume excess H_(2)O_(2) generated during GOx oxidation,and thus reduce the risk of inflammation toward the normal *** in vivo study on type 1 diabetic mice demonstrates that the platform can effectively regulate blood glucose levels within normal ranges for a prolonged period.

关键词： drug delivery diabetes glucose-responsive ph-sensitive microneedle

Tribological behavior of thermal- and ph-sensitive microgels under steel/CoCrMo alloy contacts

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Friction 2023年第4期11卷 602-616页

作者： Kequn SUN Yuanhua HU Yinghui DONG Lulu YAO Ruhong SONG Yufu XU Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China

The tribological behavior of 316L stainless steel/CoCrMo alloy contacts under aqueous lubrication was investigated in this *** types of microgels including poly(N-isopropylacrylamide)(PNIPAM),polyacrylic acid(PAA),and poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA)were prepared and used as lubricant additives in aqueous *** tests were conducted using a ball-on-disk reciprocating tribometer,over a range of temperatures,ph,and concentrations of the *** PNIPAM-co-PAA microgels were proven to have excellent anti-friction and anti-wear properties,depending on the temperature and ph values of the *** maximum friction coefficient coincided with the lower critical solution temperature of the PNIPAM-co-PAA microgels at 32°*** the same time,the friction coefficient increased with the increase in ph value of the lubricant solution with the PNIPAM-co-PAA *** unique thermal-and ph-sensitive properties of the PNIPAM-co-PAA microgels provided a new strategy for controlling the friction and wear of steel/CoCrMo alloy contacts under aqueous lubrication.

关键词： poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA) microgel aqueous lubrication thermal-sensitive ph-sensitive

Two-photon AIE probe conjugated theranostic nanoparticles for tumor bioimaging and ph-sensitive drug delivery

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Nano Research 2019年第7期12卷 1703-1712页

作者： Boxuan Ma Weihua Zhuang Haiyang He Xin Su Tao Yu Jun Hu Li Yang Gaocan Li Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China

Nanoparticles armed with chemotherapy drug and fluorescence probe have become an effective anticancer strategy for their advantages in cancer diagnosis and ***,fluorophore for diagnostic medicine with deep penetration depth and high resolution are still very rare,while rational designs are also required to improve the tumor retention and target-site drug ***,a two-photon fluorophore with aggregation-induced emission and large two-photon absorption cross-section has been designed for two-photon bioimaging,and a novel theranostic nanoplatform is also constructed based on doxorubicin and the two-photon fluorophore conjugated copolymer,P(TPMA-co-AEMA)-PEI(DA)-Blink-PEG (PAEEBlink-DA).The micelles maintain a “stealth” property during blood circulation and is activated in the acidic tumor microenvironment,which triggers the charge-conversion and results in enhanced micellar ***,PAEMA chains can convert from hydrophobicity to hydrophilicity with accelerated drug release and particle size *** enlarged particle size would potentially extend the retention time of these ***,a great AIE active two-photon bioimaging with tissue penetration depth up to 150 μm is observed and the in vivo biodistribution of nanoparticles can be *** in vivo antitumor results further indicate the obvious reduction of adverse effect and enhanced treatment effect of these micelles,proving that these PAEEBlink-DA micelles would be a potential candidate for tumor theranostic applications.

关键词： polymeric micelle two-photon aggregation-induced emission ph-sensitive charge conversion tumor retention