pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

作     者：Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing 

作者机构：Division of Chemistry and Biological ChemistrySchool of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore School of Chemical and Biomedical EngineeringNanyang Technological University70 Nanyang DriveSingapore 637459Singapore School of Electrical and Electronic EngineeringNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2019年第12卷第1期

页      面：49-55页

核心收录：

学科分类：07[理学] 0702[理学-物理学] 

基　　金：the financial supports from NTU-AIT-MUV NAM/16001 RG110/16(S) (RG 11/13)and(RG 35/15)awarded in Nanyang Technological University and the National Natural Science Foundation of China(NSFC)(No.51628201) 

主　　题：charge-transfer nanocomplex second near-infrared window photoacoustic imaging pH-sensitive biodegradable tumor acidic microenvironment 

摘      要：The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable ***,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and ***,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3 ,5,5 -tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(*** pH5)in mice with higher signal-to-noise *** CTN is biodegradable under physiological conditions(*** 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in *** results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.