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The Improvement of Soybean Salt Tolerance by overexpressed GmPAO1

Phyton-International Journal of Experimental Botany 2023年第4期92卷 1109-1124页

作者： Yeyao Du Yang Song Ye Zhang Sujie Fan Hanzhu Zhang Piwu Wang College of Agronomy Jilin Agricultural UniversityChangchun130118China

Polyamines play an important regulatory role during plant growth and development and adversity stress,and polyamine oxidase(PAO)is involved in polyamine *** this study,an up-regulated polyamine oxidase gene GmPAO1 was obtained by transcriptome sequencing analysis and screening at soybean seedling ***,its expression pattern and function were *** identification results of transgenic GmPAO1 soybean positive lines showed that the relative expression level of GmPAO1 in the overexpressed lines was increased under salt *** increasing stress concentration,the seed germination rate ***,the seed germination rate of the overexpressed lines was significantly higher than that of the control lines,and the phenotypic character of the root systems was also better than that of the control *** measurement of superoxide dismutase(SOD)and peroxidase(POD)activities and malondialdehyde and hydrogen peroxide contents revealed that the overexpressed soybean lines significantly increased the SOD and POD activities,significantly reducing the malondialdehyde *** the hydrogen peroxide content in the transformed plants gradually increased,the hydrogen peroxide content in the overexpression lines was still lower than that in the gene editing *** on this,it was preliminarily judged that GmPAO1 can improve soybean salt tolerance.

关键词： Soybean polyamine oxidase salt tolerance overexpressed

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5-Fluorocytosine–Sugar Conjugates for Glucose Transporter-Mediated Tumor Targeting: Synthesis, Cytotoxicity, and Cellular Uptake Mechanism

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Transactions of Tianjin University 2019年第6期25卷 611-617页

作者： Yu Wang Xiaofei Cheng Hongxia Zhao Qingzhi Gao Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and Technology Tianjin University

Two novel sugar-conjugated 5-fluorocytosine(5-FC)antineoplastic compounds were designed and synthesized to improve the selective drug uptake by targeting the tumor-specific glucose transporter(GLUT).The antitumor activity of these compounds was evaluated in four different human cancer cell lines:A549(human lung cancer cell line),HT29(human colorectal cancer cell line),H460(human lung cancer cell line),and PC3(human prostate cancer cell line).The sugar conjugates exhibited cytotoxicity similar to or higher than 5-FC and 1-hexylcarbamoyl-5-FC in A549,HT29,H460,and ***,GLUT-mediated transport of the glycoconjugate was investigated with GLUT inhibitor-mediated cytotoxicity analysis in a GLUT-overexpressing HT29 cell *** cell-killing potency of 5-FC glycoconjugate was found to depend significantly on the GLUT inhibitor,and the cellular uptake of molecules was regulated by GLUT-mediated *** the results demonstrate the potential advantages of glycoconjugation for Warburg effect-targeted drug design.

关键词： Warburg effect Glucose transporter overexpressed 5-Fluorocytosine glycoconjugate Tumor targeting

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Developmental study on the immunocytochemical localization of NOV protein-containing neurons in the rat brain

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Chinese Science Bulletin 1999年第15期44卷 1397-1401页

作者： Perbal.B Universite Paris Ⅶ Paris France

The localization and development of nephroblastoma overexpressed gene (nov) protein-immunoreactive neurons in the brain of E8-P300 rats have been studied using immunocytochemistry and image analysis. Results are as follows: No NOV protein-immunoreactive cells were detected in the rat brain during prenatal development. A few of positive cells were detected at the early postnatal stage. However, the number and the immunoreactivity of these cells increased gradually at later stages. NOV-immunoreactive cells were widely distributed in the rat brain during P30-P60. The number of immunoreactive cells and their intensity also peaked within this stage. The number and staining intensity of NOV-positive cells decreased gradually with age. The positive cells were mainly located in cingulate cortex, striatum, hippocampus, hypothalamus, cerebellum and brain stem. The present results indicate that nov may play an important role in the development and differentiation of brain as well as maintaining the function of

关键词： nephroblastoma overexpressed gene (nov) immunocytochemistry brain rat development.

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