检索结果-南通市图书馆

Burden of routine orthopedic implant removal a single center retrospective study

World Journal of orthopedics 2024年第2期15卷 139-146页

作者： Ammar K AlOmran Nader Alosaimi Ahmed A Alshaikhi Omar M Bakhurji Khalid J Alzahrani Basil Ziyad Salloot Tamim Omar Alabduladhem Ahmed I AlMulhim Arwa Alumran Department of orthopedic College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Health Information Management and Technology Department Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND Open reduction and internal fixation represent prevalent orthopedic procedures,sparking ongoing discourse over whether to retain or remove asymptomatic implants.Achieving consensus on this matter is paramount for orthopedic surgeons.This study aims to quantify the impact of routine implant removal on patients and healthcare facilities.A retrospective analysis of implant removal cases from 2016 to 2022 at King Fahad Hospital of the University(KFHU)was conducted and subjected to statistical scrutiny.Among these cases,44%necessitated hospitalization exceeding one day,while 56%required only a single day.Adults exhibited a 55%need for extended hospital stays,contrasting with 22.8%among the pediatric cohort.The complication rate was 6%,with all patients experiencing at least one complication.Notably,34.1%required sick leave and 4.8%exceeded 14 d.General anesthesia was predominant(88%).Routine implant removal introduces unwarranted complications,particularly in adults,potentially prolonging hospitalization.This procedure strains hospital resources,tying up the operating room that could otherwise accommodate critical surgeries.Clearly defined institutional guidelines are imperative to regulate this practice.AIM To measure the burden of routine implant removal on the patients and hospital.METHODS This is a retrospective analysis study of 167 routine implant removal cases treated at KFHU,a tertiary hospital in Saudi Arabia.Data were collected in the orthopedic department at KFHU from February 2016 to August 2022,which includes routine asymptomatic implant removal cases across all age categories.Nonroutine indications such as infection,pain,implant failure,malunion,nonunion,restricted range of motion,and prominent hardware were excluded.Patients who had external fixators removed or joints replaced were also excluded.RESULTS Between February 2016 and August 2022,360 implants were retrieved;however,only 167 of those who met the inclusion criteria were included in this study.The remaining implants were rejected due

关键词： implant removal Healed fracture orthopedic implant Complications Healthcare system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface

引用

World Journal of Stem Cells 2020年第7期12卷 545-561页

作者： Shi-Cheng Huo Bing Yue Department of Bone and Joint Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Bone marrow-derived mesenchymal stem cells(BMSCs)play a critical role in the osseointegration of bone and orthopedic implant.However,osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium’s inherent defects.Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate.Here,we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys.We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration,and discuss recent advances in understanding their role in regenerative medicine.We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

关键词： Bone marrow mesenchymal stem cells Osseointegration orthopedic implant Biofunctionalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accelerated fracture healing by osteogenic Ti45Nb implants through the PI3K–Akt signaling pathway

引用

Bio-Design and Manufacturing 2023年第6期6卷 718-734页

作者： Jia Tan Jiaxin Li Zhaoyang Ran Junxiang Wu Dinghao Luo Bojun Cao Liang Deng Xiaoping Li Wenbo Jiang Kai Xie Lei Wang Yongqiang Hao Shanghai Key Laboratory of Orthopaedic implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Ningxia Orient Ta Ind Co. Ltd.Shizuishan 753000China

The key to managing fracture is to achieve stable internal fixation,and currently,biologically and mechanically appropriate internal fixation devices are urgently needed.With excellent biocompatibility and corrosion resistance,titanium–niobium alloys have the potential to become a new generation of internal fixation materials for fractures.However,the role and mechanism of titanium–niobium alloys on promoting fracture healing are still undefined.Therefore,in this study,we systematically evaluated the bone-enabling properties of Ti45Nb via in vivo and in vitro experiments.In vitro,we found that Ti45Nb has an excellent ability to promote MC3T3-E1 cell adhesion and proliferation without obvious cytotoxicity.Alkaline phosphatase(ALP)activity and alizarin red staining and semiquantitative analysis showed that Ti45Nb enhanced the osteogenic differentiation of MC3T3-E1 cells compared to the Ti6Al4V control.In the polymerase chain reaction experiment,the expression of osteogenic genes in the Ti45Nb group,such as ALP,osteopontin(OPN),osteocalcin(OCN),type 1 collagen(Col-1)and runt-related transcription factor-2(Runx2),was significantly higher than that in the control group.Meanwhile,in the western blot experiment,the expression of osteogenic-related proteins in the Ti45Nb group was significantly increased,and the expression of PI3K–Akt-related proteins was also higher,which indicated that Ti45Nb might promote fracture healing by activating the PI3K–Akt signaling pathway.In vivo,we found that Ti45Nb implants accelerated fracture healing compared to Ti6Al4V,and the biosafety of Ti45Nb was confirmed by histological evaluation.Furthermore,immunohistochemical staining confirmed that Ti45Nb may promote osteogenesis by upregulating the PI3K/Akt signaling pathway.Our study demonstrated that Ti45Nb exerts an excellent ability to promote fracture healing as well as enhance osteoblast differentiation by activating the PI3K/Akt signaling pathway,and its good biosafety has been confirmed,which indicates its clinical translation potent

关键词： Fracture healing Ti45Nb alloy PI3K–Akt pathway orthopedic implant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

orthopedic implants and devices for bone fractures and defects:Past,present and perspective

再生工程(英文)

引用

再生工程(英文) 2020年第1期1卷 6-18页

作者： Tiffany Kim Carmine Wang See Xiaochun Li Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNew York 11794United States Department of Mechanical and Aerospace Engineering &Department of Materials Science and EngineeringUniversity of California Los AngelesLos AngelesCA 90095United States

Bone is a unique tissue that is capable of repairing itself after damage.However,there are certain instances of fractures and defects that require clinical intervention for proper alignment and healing.As with any implant,careful consideration of the material used to create the implants to treat these problems is needed.If the incorrect material is chosen,the implants themselves can lead to bone fractures or defects,or bone healing may not take place at all.All three classes of biomaterials-metals,ceramics,and polymers-have been used in the treatment of both bone fractures and bone defects,and each has its own unique benefits and limitations for its applications.Furthermore,composites of these different materials have also been created to try to take advantage of all the different benefits offered by each different material.This review highlights different materials that have been used for the development of internal fixators and bone graft substitutes to treat fracture and bone defects as well as their limitations and needed future research.

关键词： Bone scaffold Bone fracture Bone defect orthopedic implant orthopedic device

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Innovations in osteomyelitis research:A review of animal models

引用

Animal Models and Experimental Medicine 2021年第1期4卷 59-70页

作者： Kylie M.Roux Leah H.Cobb Marc A.Seitz Lauren B.Priddy College of Veterinary Medicine Mississippi State UniversityMississippi StateMSUSA Department of Agricultural and Biological Engineering Mississippi State UniversityMississippi StateMSUSA

Infection of bone tissue,or osteomyelitis,has become a growing concern in modern healthcare due in no small part to a rise in antibiotic resistance among bacteria,notably Staphylococcus aureus.The current standard of care involves aggressive,prolonged antibiotic therapy combined with surgical debridement of infected tissues.While this treatment may be sufficient for resolving a portion of cases,recurrences of the infection and associated risks including toxicity with long-term antibiotic usage have been reported.Therefore,there exists a need to produce safer,more efficacious options of treatment for osteomyelitis.In order to test treatment regimens,animal models that closely mimic the clinical condition and allow for accurate evaluation of therapeutics are necessary.Establishing a model that replicates features of osteomyelitis in humans continues to be a challenge to scientists,as there are many variables involved,including choosing an appropriate species and method to establish infection.This review addresses the refinement of animal models of osteomyelitis to reflect the clinical disease and test prospective therapeutics.The aim of this review is to explore studies regarding the use of animals for osteomyelitis therapeutics research and encourage further development of such animal models for the translation of results from the animal experiment to human medicine.

关键词： animal model bone infection orthopedic implant osteomyelitis Staphylococcus aureus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle

引用

Bioactive Materials 2021年第7期6卷 1853-1866页

作者： Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye Department of orthopedics Centre for Orthopaedic ResearchOrthopedics Research Institute of Zhejiang UniversityThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000PR China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang-California International Nanosystem InstituteZhejiang UniversityHangzhou 310058PR China School of Material Science and Engineering University of New South WalesSydney 2052Australia New York University Medical Center New York UniversityNew York10016USA

Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength.

关键词： Antibacterial properties Zinc orthopedic implant Biomimetic apatite mineral Multifunctional coating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved osteointegration and angiogenesis of strontium-incorporated 3D-printed tantalum scaffold via bioinspired polydopamine coating

引用

Journal of Materials Science & Technology 2021年第10期69卷 106-118页

作者： Shi Cheng Jin Ke Mengyu Yao Hongwei Shao Jielong Zhou Ming Wang Xiongfa Ji Guoqing Zhong Feng Peng Limin Ma Yu Zhang Department of orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China

Tantalum(Ta)is used in orthopedic implants because it has excellent biocompatibility.However,high elastic modulus,bio-inertness,and unsatisfactory osteointegration limits its wider use in clinical applications.Herein,a 3 D porous Ta scaffold with low elastic modulus was fabricated using selective laser melting(SLM).Strontium(Sr)was incorporated on the surface of the scaffold with the aid of polydopamine(PDA)to further improve its osteointegration ability.The prepared scaffolds exhibited a stable Sr ion release in 14 d.Rat bone marrow stem cells(BMSCs)showed improved early adhesion and spreading after Sr was incorporated on the porous Ta surface.The osteogenic behavior,including extracellular matrix mineralization(ECM),alkaline phosphatase activity(ALP),and expression of bone-related RNA,were all enhanced.Furthermore,the Sr-incorporated porous Ta scaffolds exhibited better angiogenic behavior,such as promoting migration,tube formation,and angiogenesis-related RNA expression abilities of human vascular endothelial cells(HUVECs).Additionally,histological images(H&E,Masson and CD31 immunofluorescent staining)suggested that Sr-incorporated porous Ta scaffolds displayed enhanced osteointegration and angiogenesis after implantation in rat femur for 12 weeks.These findings prove that the PDA-based Sr-incorporated porous Ta scaffolds show promising use in orthopedic implants.

关键词： 3D Ta scaffold Strontium Osteogenesis Angiogenesis orthopedic implant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Titanium-niobium pentoxide composites for biomedical applications

引用

Bioactive Materials 2016年第2期1卷 127-131页

作者： Yuncang Li Khurram S.Munir Jixing Lin Cuie Wen School of Engineering RMIT UniversityMelbourneVictoria 3001Australia Department of Materials Science and Engineering Jilin UniversityChangchunJilin 130025China Advanced Material Research and Development Center Zhejiang Industry&Trade Vocational CollegeWenzhouZhejiang 325003China

The strength of titanium scaffolds with the introduction of high porosity decreases dramatically and may become inadequate for load bearing in biomedical applications.To simultaneously meet the requirements of biocompatibility,low elastic modulus and appropriate strength for orthopedic implant materials,it is highly desirable to develop new biocompatible titanium based materials with enhanced strength.In this study,we developed a niobium pentoxide(Nb2O5)reinforced titanium composite via powder metallurgy for biomedical applications.The strength of the Nb2O5 reinforced titanium composites(Ti-Nb2O5)is significantly higher than that of pure titanium.Cell culture results revealed that the Ti-Nb2O5 composite exhibits excellent biocompatibility and cell adhesion.Human osteoblast-like cells grew and spread healthily on the surface of the Ti-Nb2O5 composite.Our study demonstrated that Nb2O5 reinforced titanium composite is a promising implant material by virtue of its high mechanical strength and excellent biocompatibility.

关键词： Titanium-niobium pentoxide composite Particulate-reinforcement orthopedic implant Mechanical property Biocompatibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：