检索结果-南通市图书馆

The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

Neural Regeneration Research 2024年第1期19卷 22-28页

作者： Caiyun Liu Haixin Yu Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture Science Tianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina Binhai New Area Hospital of TCM TianjinChina Fourth Teaching Hospital of Tianjin University of TCM TianjinChina

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system *** present,no effective clinical treatment *** one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord ***,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord *** hibernation is a futureoriented disruptive technology for human life *** involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold ***,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia *** review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation *** summarizes the relevant research on hypothermia and hibernation for organ and nerve *** studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central *** also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine *** review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial *** present,artificial hibernation technology is not mature,and research fa ces various *** rtheless,the effort is wo rthwhi

关键词： artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liver protection strategies in liver transplantation

引用

Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 34-42页

作者： Jun-Jun Jia Jian-Hui Li Li Jiang Bin-Yi Lin Li Wang Rong Su Lin Zhou Shu-Sen Zheng Key Laboratory of Combined Multi-organ Transplantation Ministry of Health Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND： Liver transplantation is the therapy of choice for patients with end-stage liver diseases. However, the gap between the low availability of organs and high demand is continuously increasing. Innovative strategies for organ protection are necessary to expand donor pool and to achieve better outcomes for liver transplantation. The present review analyzed and compared various strategies of liver *** SOURCES： Databases such as PubM ed, Embase and Ovid were searched for the literature related to donor liver protection strategies using following key words：＂ischemia reperfusion injury＂, ＂graft preservation＂, ＂liver transplantation＂, ＂machine perfusion＂ and ＂conditioning＂. Of the 146 studies identified,only those with cutting edge strategies were ***： A variety of therapeutic approaches were proposed to alleviate graft ischemia/reperfusion injury, which included static cold storage, machine perfusion （hypothermic, normothermic and subnormothermic）, manual conditioning （pre,post and remote）, and pharmacological conditioning. Evidences from animal experiments and clinical trials suggested that all these strategies could potentially protect liver graft; however, their clinical applications are limited partially due to their own ***： There are a plenty of methods suggested to decrease the degree of donor liver transplantation-related injury. However, none of these approaches is perfect in clinical practice. More translational researches （molecular and clinical studies） are needed to improve the techniques in liver graft protection.

关键词： ischemia reperfusion injury liver transplantation organ protection conditioning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome?

引用

Journal of Intensive Medicine 2022年第4期2卷 241-248页

作者： Jiangli Cheng Aijia Ma Meiling Dong Yongfang Zhou Bo Wang Yang Xue Peng Wang Jing Yang Yan Kang Department of Critical Care Medicine West China Hospital of Sichuan UniversityChengduSichuan 610041China

Mechanical ventilation(MV)is an essential life support method for patients with acute respiratory distress syn-drome(ARDS),which is one of the most common critical illnesses with high mortality in the intensive care unit(ICU).A lung-protective ventilation strategy based on low tidal volume(LTV)has been recommended since a few years;however,as this did not result in a significant decrease of ARDS-related mortality,a more optimal venti-lation mode was *** pressure release ventilation(APRV)is an old method defined as a continuous positive airway pressure(CPAP)with a brief intermittent release phase based on the open lung concept;it also perfectly fits the ARDS treatment *** this,APRV has not been widely used in the past,rather only as a rescue measure for ARDS patients who are difficult to *** recent years,with an increased under-standing of the pathophysiology of ARDS,APRV has been reproposed to improve patient ***,this mode is still not routinely used in ARDS patients given its vague definition and ***,in this paper,we summarize the studies that used APRV in ARDS,including adults,children,and animals,to illustrate the settings of parameters,effectiveness in the population,safety(especially in children),incidence,and mechanism of ventilator-induced lung injury(VILI)and effects on extrapulmonary ***,we found that APRV is likely associated with improvement in ARDS outcomes,and does not increase injury to the lungs and other organs,thereby indicating that personalized APRV settings may be the new hope for ARDS treatment.

关键词： Acute respiratory distress syndrome Airway pressure release ventilation Ventilator-induced lung injury Outcome organ protection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel intravenous general anesthetic—emulsified isoflurane:from bench to bedside

引用

Frontiers of Medicine 2012年第4期6卷 381-387页

作者： Cheng Zhou Jin Liu Department of Anesthesiology and Translational Neuroscience Center West China HospitalSichuan UniversityChengdu 610041China

Application of volatile anesthetics greatly alters modern *** are obvious advantages of volatile anesthetics such as strong anesthetic potency,rapid onset and elimination through respiration *** is one of the most widely used volatile anesthetics in *** isoflurane,the emulsion of isoflurane,is a novel intravenous general *** the development of emulsified isoflurane in the past fifteen years,its utility has spread from intravenous general anesthesia to various fields including regional anesthesia,organ protection,as well as anesthetic pharmacological *** this review,we will summarize literatures of emulsified isoflurane about its history,clinical application and future potential utility in the above mentioned fields.

关键词： emulsified isoflurane(EI) general anesthesia regional anesthesia organ protection anesthetic pharmacological study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure

引用

Liver Research 2021年第2期5卷 37-44页

作者： Transplantation Immunology Committee of Branch of organ Transplantation Physician of Chinese Medical Doctor Association Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Society Guihua Chen Yang Yang Huimin Yi Jianrong Liu Pinglan Lu Lijuan Li Mingming Fan Xiaomeng Yi Haijin Lv Xuxia Wei 不详 The Third Affiliated Hospital of SunYat-sen University Department of Hepatic Surgery Liver Transplantation CenterIntensive Care Unit of Organ TransplantationThe Third Affiliated Hospital of SunYat-sen UniversityGuangzhouChina

Acute-on-chronic liver failure(ACLF)is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver ***,liver transplantation is the only effective treatment for *** is still room for discussion on the optimal surgery timing for ACLF,perioperative infection prevention and control,and maintenance of nutrition and organ *** Transplantation Immu-nology Committee of Branch of organ Transplantation Physician of Chinese Medical Doctor Association and Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Association invited relevant experts to discuss the perioperative management of ACLF liver transplantation in areas including surgery timing,organ protection,nutritional support,infection prevention and control,rehabilitation exercises,regulation of the internal environment,*** expert consensus was developed as reference for clinicians.

关键词： Acute-on-chronic liver failure Chronic liver disease Infection prevention and control Liver transplantation Nutritional support organ protection Rehabilitation exercise Surgery timing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：