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Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China:insights from ERS-COVID-19 study

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1895-1897页

作者： Dongze Li You Chen Hong Liu Yu Jia Fanghui Li Wei Wang Jiang Wu Zhi Wan Yu Cao Rui Zeng Department of Emergency Medicine and Laboratory of Emergency Medicine Deep Underground Space Medical CenterDisaster Medical CenterWest China School of NursingWest China HospitalSichuan UniversityChengduChina Department of Cardiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Cardiology West China HospitalSichuan UniversityChengduChina

Dear Editor,A series of novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)since the end of 2019 is ongoing and triggering a global public health *** estimated case fatality rate is approximately 3.4%in ***,some patients experience dyspnea within 1 week and develop rapidly to organ injury and even death within 2 weeks after dyspnea.1 In addition,early organ injury could lead to higher risks of ***,early identification of patients at risk of organ injury and death is crucial,which saves the patients from classified and invasive treatment,improving clinical outcome and *** human immune system plays significant roles in the resistance of foreign pathogens and the progress of *** studies have mentioned that T cells were decreased in COVID-19 patients,excessive activated immune response was caused by pathogenic Th1 cells,and inflammatory CD14+CD16+monocytes may connect to pulmonary immunopathology,leading to deleterious clinical manifestations and even acute mortality after SARS-CoV-2 infections.2 SARS-CoV-2 might damage lymphocytes,especially T lymphocytes,and the immune system was impaired during the period of disease to cause tissue injury.

关键词： COVID-19 Immune dysfunction Mortality organ injury

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The toxicological effect of dietary excess of saccharicterpenin,the extract of camellia seed meal,in piglets

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Journal of Integrative Agriculture 2020年第1期19卷 211-224页

作者： WANG Man YU Bing HE Jun YU Jie LUO Yu-heng LUO Jun-qiu MAO Xiang-bin CHEN Dai-wen Key Laboratory of Animal Disease-Resistance Nutrition Animal Nutrition InstituteSichuan Agricultural University

Recently, saccharicterpenin extracted from Camellia oleifera seed meal has become a widely used feed supplement in animal husbandry. In order to assess its safety, this study was designed to investigate the toxicity and histopathological effects of saccharicterpenin on piglets. One hundred-fifty weaned pigs((Yorkshire×Landrace)×Duroc), 75 males and 75 females with body weight(BW) of(7.35±0.29) kg, were randomly allotted to groups receiving diets supplemented with 0, 500, 1 000, 2 500 or 5 000 mg kg^–1 saccharicterpenin for 70 d. The diet with 500 mg kg^–1 saccharicterpenin supplementation improved liver glutathione peroxidase(GSH-Px) activity, and the diet with 1 000 mg kg^–1 saccharicterpenin supplementation improved liver glutathione S-transferase(GSH-S) activity in piglets on d 70(Porgan injuries.

关键词： growth retardation hematology organ injury piglets saccharicterpenin

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Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis

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Chinese Medical Journal 2022年第23期135卷 2773-2784页

作者： Hongxin Kang Yue Yang Lv Zhu Xianlin Zhao Juan Li Wenfu Tang Meihua Wan Department of Integrated Traditional Chinese and Western Medicine National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China

Severe acute pancreatitis(SAP)is a life-threatening acute abdominal disease with two peaks of death:the first in the early stage,characterized by systemic inflammatory response-associated organ failure;and the second in the late stage,characterized by infectious *** are the main immune cells participating in the whole process of *** addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens,neutrophil extracellular traps(NETs)also play an important roles in inflammatory *** reviewed the role of NETs in the occurrence and development of SAP and its fatal complications,including multiple organs injury,infected pancreatic necrosis,and *** review provides novel insights into the involvement of NETs throughout the entire process of SAP,showing that targeting NETs might be a promising strategy in SAP ***,precision therapeutic options targeting NETs in different situations require further investigation.

关键词： Inflammation Neutrophil extracellular traps organ injury Sepsis Severe acute pancreatitis Thrombus

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Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization

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World Journal of Gastroenterology 2005年第9期11卷 1303-1316页

作者： Christine Fallsehr Christina Zapletal Michael Kremer Resit Demir Magnus von Knebel Doeberitz Ernst Klar Institute of Molecular Pathology Department of Surgery

AIM: To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs. METHODS: We used two strategies (SSH suppression subtractive hybridization and hybridization of cDNA arrays) to determine early changes in gene expression profiles in a rat model of partial WI/R, comparing postischemic and adjacent nonischemic liver lobes. Differential gene expression was verified (WI/R; 1 h/2 h) and analyzed in more detail after warm ischemia (1 h) in a reperfusion time kinetics (0, 1, 2 and 6 h) and compared to untreated livers by Northern blot hybridizations. Protein expression was examined on Western blots and by immunohistochemistry for four differentially expressed target genes (Hsp70, Hsp27, Gadd45a and IL-1rI). RESULTS: Thirty-two individual WI/R target genes showing altered RNA levels after confirmation by Northern blot analyzes were identified. Among them, six functionally uncharacteristic expressed sequences and 26 known genes (12 induced in postischemic liver lobes, 14 with higher transcriptional expression in adjacent nonischemic liver lobes). Functional categories of the verified marker genes indicate on the one hand cellular stress and tissue damage but otherwise activation of protective cellular reactions (AP-1 transcription factors, apoptosis related genes, heat shock genes). In order to assign the transcriptional status to the biological relevant protein level we demonstrated that Hsp70, Hsp27, Gadd45a and IL-1rI were clearly up-regulated comparing postischemic and untreated rat livers, suggesting their involvement in the WI/R context. CONCLUSION: This study unveils a WI/R response gene set that will help to explore molecular pathways involved in the tissue damage after WI/R. In addition, these genes especially Hsp70 and Gadd45a might represent promising new candidates indicating WI/R liver damage.

关键词： organ injury Liver ischemia AP-1 transcription factor Heat shock protein Gadd45A Suppression subtractive hybridization

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Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell injury

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World Journal of Gastroenterology 2011年第2期17卷 213-218页

作者： Sebastiaan J Hanssen Tim Lubbers Caroline M Hodin Frits W Prinzen Wim A Buurman Michael J Jacobs Department of Surgery Maastricht University Medical Center Cardiovascular Research Institute Maastricht Maastricht University Medical Center European Vascular Center Aachen-Maastricht Department of Vascular SurgeryUniversity Hospital Aachen Nutrition and Toxicology Research Institute Maastricht Maastricht University Medical Center Department of Physiology Maastricht University Medical Center

AIM:To study the effect of circulating cell-free oxy-hemoglobin(FHb) on intestinal microcirculation and intestinal epithelial injury in a rat model. METHODS:To induce elevated intravascular circulating FHb,male Sprague-Dawley rats received water or FHb *** changes in jejunum,ileum and colon were evaluated using fluorescent *** injury was quantified as plasmatic release of ileal lipid binding protein(iLBP) and verified by histological analysis of the ileum. RESULTS:Water and FHb infusions resulted,when compared with saline infusion,in reduced intestinal microcirculation(after 30 min Pinjury of the villi was histologically observed after water and FHb infusions. CONCLUSION:This study shows that circulating FHb leads to a reduction in intestinal microcirculatory blood flow with marked injury to intestinal epithelial cells. These data support the hypothesis that circulating FHb contributes to the development of intestinal injury.

关键词： Hemoglobin Microcirculation organ injury Vasoconstriction

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