Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis

作     者：Hongxin Kang Yue Yang Lv Zhu Xianlin Zhao Juan Li Wenfu Tang Meihua Wan Hongxin Kang;Yue Yang;Lv Zhu;Xianlin Zhao;Juan Li;Wenfu Tang;Meihua Wan

作者机构：Department of Integrated Traditional Chinese and Western MedicineNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第23期

页      面：2773-2784页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Natural Science Foundation ofChina(Nos.81974552,81774160) the Scientific Research Foundation of the Science and Technology Department of Sichuan Province(No.2022YFS0417) 

主　　题：Inflammation Neutrophil extracellular traps Organ injury Sepsis Severe acute pancreatitis Thrombus 

摘      要：Severe acute pancreatitis(SAP)is a life-threatening acute abdominal disease with two peaks of death:the first in the early stage,characterized by systemic inflammatory response-associated organ failure;and the second in the late stage,characterized by infectious *** are the main immune cells participating in the whole process of *** addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens,neutrophil extracellular traps(NETs)also play an important roles in inflammatory *** reviewed the role of NETs in the occurrence and development of SAP and its fatal complications,including multiple organs injury,infected pancreatic necrosis,and *** review provides novel insights into the involvement of NETs throughout the entire process of SAP,showing that targeting NETs might be a promising strategy in SAP ***,precision therapeutic options targeting NETs in different situations require further investigation.