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optogenetics stimulates nerve reorganization in the contralesional anterolateral primary motor cortex in a mouse model of ischemic stroke

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Neural Regeneration Research 2022年第7期17卷 1535-1544页

作者： Bei-Yao Gao Yi-Xing Cao Peng-Fei Fu Ying Xing Dan Liang Shan Jiang Yu-Xiao Xie Min Li Department of Rehabilitation Medicine China-Japan Friendship HospitalBeijingChina Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghaiChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Huashan HospitalFudan UniversityShanghaiChina

The anterolateral motor cortex of rodents is an important motor auxiliary area,and its function is similar to that of the premotor area in *** and inhibition of the contralesional anterolateral motor cortex(cALM)have been shown to have direct effects on motor ***,the significance of cALM activation and inhibition in the treatment of stroke remains *** study investigated the role of optogenetic cALM stimulation in a mouse model of cerebral *** results showed that 21-day optogenetic cALM inhibition,but not activation,improved neurological *** addition,optogenetic cALM stimulation substantially altered dendritic structural reorganization and dendritic spine plasticity,as optogenetic cALM inhibition resulted in increased dendritic length,number of dendritic spines,and number of perforated synapses,whereas optogenetic activation led to an increase in the number of multiple synapse boutons and the number of dendritic ***,RNA-seq analysis showed that multiple biological processes regulated by the cALM were upregulated immediately after optogenetic cALM inhibition,and that several immediate-early genes(including cFOS,Erg1,and Sema3f)were expressed at higher levels after optogenetic inhibition than after optogenetic *** results were confirmed by quantitative reverse transcription-polymerase chain ***,immunofluorescence analysis showed that the c-FOS signal in layer V of the primary motor cortex in the ischemic hemisphere was higher after optogenetic cALM activation than it was after optogenetic cALM *** together,these findings suggest that optogenetic cALM stimulation promotes neural reorganization in the primary motor cortex of the ischemic hemisphere,and that optogenetic cALM inhibition and activation have different effects on neural *** study was approved by the Experimental Animal Ethics Committee of Fudan University(approval No.201802173 S)on March

关键词： anterolateral motor cortex locomotion activity middle cerebral artery occlusion motor function neural plasticity optogenetics stroke synapse

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optogenetics:a novel optical manipulation tool for medical investigation

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 517-522页

作者： Jun-Ping Yao, Zheng-Qin Yin College of Biology Engineering Chongqing University Chongqing 400044 China Department of Ophthalmology the Third Military Medical University Chongqing 400038 China Chongqing Key Lab of Visual Damage and Regeneration and Restoration Chongqing 400038 China

optogenetics is a new and rapidly evolving gene and neuroengineering technology that allows optical control of specific populations of neurons without affecting other neurons in the brain at high temporal and spatial resolution. By heterologous expression of the light-sensitive membrane proteins, cell type-specific depolarization or hyperpolarization can be optically induced on a millisecond time scale. optogenetics has the higher selectivity and specificity compared to traditional electrophysiological techniques and pharmaceutical methods. It has been a novel promising tool for medical research. Because of easy handling, high temporal and spatial precision, optogenetics has been applied to many aspects of nervous system research, such as tactual neural circuit, visual neural circuit, auditory neural circuit and olfactory neural circuit, as well as research of some neurological diseases. The review highlights the recent advances of optogenetics in medical study.

关键词： light-sensitive proteins optogenetics optical manipulation medical

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Recent development in upconversion nanoparticles and their application in optogenetics:A review

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Journal of Rare Earths 2022年第6期40卷 847-861,I0001页

作者： Madhumita Patel Maninder Meenu Jitender Kumar Pandey Pawan Kumar Rajkumar Patel Department of Chemistry and Nano Science Ewha Womans UniversitySeodaemun-guSeoul120-750South Korea College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China School of Basic and Applied Sciences Adamas UniversityKolkata700126India Institut National de la Recherche Scientifique-Centreénergie Materiaux Télecommunications(INRS-EMT) VarennesQCCanada Department of Chemistry and Biochemistry University of Oklahoma101 Stephenson ParkwayNormanOK73019United States Energy&Environmental Science and Engineering(EESE) Integrated Science and Engineering Division(ISED)Underwood International CollegeYonsei University85 Songdogwahak-roYeonsu-guIncheon21983South Korea

Ion channels present in the plasma membrane are responsible for integration and propagation of electric signals,which transmit information in nerve *** of these ion channels leads to many neurological ***,optogenetic technology has gained a lot of attention for the manipulation of neuronal *** is a neuromodulation approach that has been developed to control neuronal functions and activities using *** lanthanide-doped upconversion nanoparticles(UCNPs)absorb low energy photons in near-infrared(NIR) window and emit high energy photons in the visible spectrum region via nonlinear *** the last few decades,UCNPs have gained great attention in various bio-medical applications such as bio-imaging,drug delivery and *** near-infrared illumination is considered more suitable for optogenetics application,due to its lower degree of light attenuation and higher tissue penetration compared to visible ***,UCNPs have been considered as the new promising candidates for optogenetics *** nanoparticlemediated optogenetic systems provide a great opportunity to manipulate the ion channel in deep ***,we summarize the upconversion photoluminescence in lanthanide doped nanomaterials and its mechanisms and several approaches adopted to tune emission color or enhance upconversion *** advances of lanthanide-doped UCNPs design strategy and their mechanism are ***,we discuss the neural circuitry modulation using upconversion nanoparticles mediated ***,the future perspectives towards optogenetics are also included.

关键词： Lanthanide Upconversion optogenetics Nanoparticles Neuronal modulation Rare earths

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Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain:Insights from optogenetics

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Neuroscience Bulletin 2022年第4期38卷 440-452页

作者： Fang Guo Yu Du Feng-Hui Qu Shi-Da Lin Zhong Chen Shi-Hong Zhang Department of Pharmacology and Department of Anesthesiology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China

Pain is an unpleasant sensory and emotional experience associated with,or resembling that associated with,actual or potential tissue *** processing of pain involves complicated modulation at the levels of the periphery,spinal cord,and *** pathogenesis of chronic pain is still not fully understood,which makes the clinical treatment ***,which combines optical and genetic technologies,can precisely intervene in the activity of specific groups of neurons and elements of the related *** advantage of optogenetics,researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission,pain modulation,and chronic pain both in the periphery and the central nervous *** this review,we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.

关键词： optogenetics Pain transmission Pain modulation Chronic pain Neural circu

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Visual prostheses, optogenetics, stem cell and gene therapies: splitting the cake

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Neural Regeneration Research 2018年第5期13卷 805-806页

作者： Alejandro Barriga-Rivera Gregg J.Suaning Division of Neuroscience University Pablo de Olavide Faculty of Engineering and Information Technologies The University of Sydney

The size of the blind population in 2015 was estimated to be approximately 36 million（Bourne et al.,2017）.According to the predictions by Bourne and co-workers,the number of the visually impaired is expected to reac... 详细信息

关键词： stem cell and gene therapies Visual prostheses optogenetics splitting the cake

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optogenetics in neuroscience:what we gain from studies in mammals

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Neuroscience Bulletin 2012年第4期28卷 423-434页

作者： Quanhui Chen Ziling Zeng Zhian Hu Department of Physiology Third Military Medical UniversityChongqing 400038China

optogenetics is a newly-introduced technology in the life sciences and is gaining increasing *** refers to the combination of optical technologies and genetic methods to control the activity of specific cell groups in living tissue,during which high-resolution spatial and temporal manipulation of cells is *** has been applied to numerous regions,including cerebral cortex,hippocampus,ventral tegmental area,nucleus accumbens,striatum,spinal cord,and retina,and has revealed new directions of research in neuroscience and the treatment of related *** optogenetic tools are controllable at high spatial and temporal resolution,we discuss its applications in these regions in detail and the recent understanding of higher brain functions,such as reward-seeking,learning and memory,and ***,the possibilities of improved utility of this newly-emerging technology are *** intend to provide a paradigm of the latest advances in neuroscience using optogenetics.

关键词： optogenetics channnelrhodopsin halorhodopsin mammals

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Application of optogenetics in the study of gastrointestinal motility:A mini review

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Journal of Innovative Optical Health Sciences 2023年第3期16卷 78-84页

作者： Song Zhao Ting Zhang Weidong Tong Department of General Surgery Gastric and Colorectal Surgery DivisionArmy Medical Center(Daping Hospital)Army Medical University ChongqingP.R.China Department of General Surgery The 983th Hospital of Joint Logistic Support Force of People's Liberation Army Tianjin P.R.China

Disorders of gastrointestinal(GI)motility are associated with various symptoms such as nausea,vomiting,and ***,the underlying causes of impaired GI motility remainunclear,which has led to variation in the efficacy of therapies to treat GI ***-netics is a novel approach through which target cells can be precisely controlled by light and hasshown great potential in GI motility ***,we summarized recent studies of GI motilitypatterns utilizing optogenetic devices and focused on the ability of opsins,which are geneticallyexpressed in different types of cells in the gut,to regulate the excitability of target *** hopethat our review of recent findings regarding optogenetic control of GI cells broadens the scope ofapplication for optogenetics in GI motility studies.

关键词： Gastrointestinal motility optogenetics

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Using optogenetics to translate the “inflammatory dialogue” between heart and brain in the context of stress

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Neuroscience Bulletin 2012年第4期28卷 435-448页

作者： Jinbo Cheng Jie Zhang Caiyi Lu Liping Wang Institute of Geriatric Cardiology PLA General HospitalBeijing 100853China Shenzhen Key Laboratory of Neuropsychiatric Modulation Shenzhen Institutes of Advanced TechnologyChineseAcademy of SciencesShenzhen 518055China

Inflammatory processes are an integral part of the stress response and are likely to result from a programmed adaptation that is vital to the organism＇s survival and *** whole inflammatory response is mediated by largely overlapping circuits in the limbic forebrain,hypothalamus and brainstem,but is also under the control of the neuroendocrine and autonomic nervous *** predisposed individuals who fail to tune the respective contributions of the two systems in accordance with stressor modality and intensity after adverse experiences can be at risk for stress-related psychiatric disorders and cardiovascular *** glucocorticoid（GC） homeostasis due to GC resistance leads to the failure of neural and negative feedback regulation of the hypothalamic-pituitary-adrenal axis during chronic inflammation,and this might be the mechanism underlying the ensuing brain and heart diseases and the high prevalence of co-morbidity between the two *** the combined use of light and genetically-encoded lightsensitive proteins,optogenetics allows cell-type-specific,fast（millisecond-scale） control of precisely defined events in biological *** method is an important breakthrough to explore the causality between neural activity patterns and behavioral profiles relevant to anxiety,depression,autism and *** also helps to understand the ＂inflammatory dialogue＂,the inflammatory processes in psychiatric disorders and cardiovascular diseases,shared by heart and brain in the context of stress.

关键词： stress inflammatory processes glucocorticoid resistance psychoneuroimmunology psychiatric disorders cardiovascular disease neuronal circuits optogenetics

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optogenetics:a new method to repair urination dysfunction after spinal cord injury?

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Neural Regeneration Research 2015年第12期10卷 1967-1967页

作者： Zhi-cheng Zhang Tian-sheng Sun Institute of Trauma Orthopedic Surgery of Chinese PLA General Hospital of Beijing Military Region

The main reason for late death in patients with spinal cord injury(SCI)is urinary tract infection and renal ***,reconstructing the urinary system functions of SCI patients can be highly *** bladder induced by SCI abov... 详细信息

关键词： optogenetics SCI

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Improved optrode array design and neural interface for optogenetics

Improved optrode array design and neural interface for optog...

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中国神经科学学会第十届全国学术会议

作者： Yi LU Cheng ZHONG Jian-Qing PAN Peng-Fei WEI Li-Ping WANG Shenzhen Key Lab of Neuropsychiatric Modulation Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Objective optogenetics is a technology that combines optical control and genetic targeting using cell-type specific and optically-sensitive proteins for the precise manipulation of neuronal *** technology has been successfully used to understand the mechanisms of neuropsychiatric diseases through the precise spatial and temporal control of specific groups of neurons in a neural ***,it remains a great challenge to integrate optogenetic modulation with electrophysiological and behavioral read out methods as a means to explore the causal,temporally precise,and behaviorally relevant interactions of neurons in the specific circuits of freely behaving ***,the aim of this study is to develop a novel optrode array for long term applications in awaken *** We have designed and fabricated a high spatial resolution,multi-channel,and drivable optrode array for optical stimulating and recording in different brain regions of a rodent model at one ***,we have also developed optimal modification methods to build a low impedance and tissue friendly optrode/neural interface based on electro-active and bio-active materials,such as conducting polymers,hydrogels,neurotrophins and *** According to the requirements in the application of implantable optrode arrays,evaluation processes and characterization of the optrode arrays,both in vitro and in vitro,were exploited and *** investigation includes the electrochemical properties and biocompatibility of the optrode/tissue interface,and the long-term stability of the electrophisiological recording signals in freely-behaving ***,some other devices based on the technique of optogenetics and electrophysiology were developed,which were used to investigate the complex neural circuit processing mechanisms at the functional *** This work will provide theoretic and technical support for the development of a new generation of optrode arrays,a

关键词： optogenetics optorde neural circuits neural modulation brain activity mapping

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