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Agreement of intraocular pressure measurement with Corvis ST,non-contact tonometer,and Goldmann applanation tonometer in children with ocular hypertension and related factors

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国际眼科杂志:英文版 2023年第10期16卷 1601-1607页

作者： Hou-Gang Li Yan-Hui Chen Fang Lin Si-Yu Li Qing-Hua Liu Chun-Ge Yin Xi-Yue Chen Xin-Jie Zhang Yue Qu Yan-Nian Hui Ophthalmic Hospital of Tangshan Tangshan 063000Hebei ProvinceChina Tianjin Jizhou District Tianyi Vision Hospital Tianjin 300070China Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’an 710023Shaanxi ProvinceChina

AIM:To access the agreement of intraocular pressure(IOP)values obtained from biomechanically corrected tonometer[Corvis ST(CST)],non-contact tonometer(NCT),and Goldmann applanation tonometer(GAT)in children with NCT measured-IOP(NCT-IOP)values of 22 mm Hg or more,and related ***:A total of 51 eyes with NCT-IOP≥22 mm Hg in children aged 7 to 14y were examined and IOP was measured by CST,NCT,and *** on GAT measured IOP(GAT-IOP),ocular hypertension(OHT)group(≥22 mm Hg,24 eyes)and the non-OHT group(<22 mm Hg,27 eyes)were *** compared the agreement of the three measurements,i.e.,CST measured IOP(CST-IOP),GAT-IOP,and NCT-IOP,and further analyzed the correlation between the differences in tonometry readings,central corneal thickness(CCT),axial length(AL),optic disc rim volume,and ***:Compared with the OHT group,thicker CCT,larger rim volume,and higher differences between NCTIOP and GAT-IOP,were found in the non-OHT *** differences between CST-IOP and GAT-IOP were lower than the differences between NCT-IOP and GAT-IOP in both *** mean differences in CST-IOP and GAT-IOP were 1.26 mm Hg(95%limit of agreement ranged from 0.1 to 2.41 mm Hg,OHT group)and 1.20 mm Hg(95%limit of agreement ranged from-0.5 to 3.00 mm Hg,non-OHT group),and the mean differences in NCT and GAT were 3.90 mm Hg(95%limit of agreement ranged from-0.19 to 9.70 mm Hg,OHT group)and 6.00 mm Hg(95%limit of agreement ranged from 1.50 to 10.50 mm Hg,non-OHT group).The differences between CST-IOP and GAT-IOP were not related to CCT,age,and AL in both groups;while the differences between NCT-IOP and GAT-IOP were related to CCT in the OHT group(r=0.93,P<0.001)and to CCT and AL in the non-OHT group(r=0.66,P<0.001,r=-0.81,P<0.001).CONCLUSION:The accuracy of NCT in the diagnosis of pediatric OHT is *** agreement of CST-IOP and GATIOP was significantly higher in children with and without OHT than in those with NCT-IOP and ***,CST can be used as a good alter

关键词： ocular hypertension children non-contact tonometer Goldmann applanation tonometer Corvis ST corneal biomechanics central corneal thickness axial length

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ocular hypertension and severe intraocular pressure elevation after posterior subtenon injection of triamcinolone acetonide for various diseases

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 946-951页

作者： Yun-Hsiang Yang Hua-Hsuan Kuo Wei-Cherng Hsu Yi-Ting Hsieh Department of Ophthalmology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei 231TaiwanChina School of Medicine Tzu Chi UniversityHualien 970TaiwanChina Department of Ophthalmology National Taiwan University HospitalTaipei 10002TaiwanChina

AIM:To evaluate and compare the incidences of ocular hyper tension and severe intraocular pressure(IOP)elevation after posterior subtenon injection of triamcinolone acetonide(PSTA)for various ***:Totally 179 eyes that had received PSTA for diabetic macular edema(n=108),pseudophakic cystoid macular edema(n=20),branch retinal vein occlusion(n=16),central retinal vein occlusion(CRVO,n=14),choroidal neovascularization(n=14)or noninfectious uveitis(n=7)were retrospectively *** primary outcomes included ocular hypertension defined as an IOP>21 mm Hg,and severe IOP elevation defined as a rise of 10 mm Hg or more in IOP compared with *** regression models were used to analyze the hazard ratios(HRs)among different ***:After PSTA,the mean IOPs from month 1 to month 6 all significantly increased(Pocular hypertension occurred in 30.7%of eyes(median time:8 wk),and severe IOP elevation occurred in 16.2%of eyes(median time:9 wk).Patients receiving PSTA for CRVO or uveitis had a significantly higher risk for ocular hypertension(HR=3.049,P=0.004 for CRVO;HR=5.464,P=0.019 for uveitis)and severe IOP elevation(HR=2.913,P=0.034 for CRVO;HR=7.650,P=0.009 for uveitis).CONCLUSION:IOP significantly increases within 6 mo after PSTA,with the onset of ocular hypertension happening mostly at 2 to 3 *** of CRVO or noninfectious uveitis have a higher risk of ocular hypertension or severe IOP elevation after PSTA and should be monitored for IOP more carefully.

关键词： intraocular pressure ocular hypertension uveitis retinal vein occlusion triamcinolone acetonide

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ocular hypertension in patients with central/hemicentral retinal vein occlusions： cumulative prevalence and management

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1173-1178页

作者： Dan Calugaru Mihai Calugaru Stefan Talu Department of Ophthalmology University of Medicine Cluj-Napoca 400467 Romania Department of AET Discipline of Descriptive Geometry and Engineering Graphics Faculty of Mechanical EngineeringTechnical University of Cluj-Napoca Cluj-Napoca 400012Romania

AIM： To prospectively evaluate the cumulative prevalence and the management of ocular hypertension（OH） in patients with unilateral acute central/hemicentral retinal vein occlusions（C/HCRVOs） over the course of 3 y. METHODS： The study included 57 patients with unilateral acute C/HCRVOs. All patients underwent a comprehensive ophthalmological examination of both eyes. OH associated with C/HCRVO in patients showing a score 〉5% for the risk of conversion to primary open angle glaucoma（POAG） was treated with OH medication. The treatment aimed for a decrease in intraocular pressure（IOP） to 〈21 mm Hg with a 〉22% reduction from the initial values. The cumulative prevalence of OH and the effectiveness of treatment assessed by the cumulative prevalence of conversion from OH to POAG, were estimated. RESULTS： Fifteen patients had OH associated with C/HCRVOs, the cumulative prevalence of OH was 29.4%（95% confidence interval, 16.9-41.9）. The mean value of the risk score of OH conversion to POAG for the 5 subsequent years was 11.7%±5.4%. The IOP significantly decreased from 25.67±2.16 mm Hg to 18.73±2.96 mm Hg. None of the OH patients converted to POAG during the follow-up period. CONCLUSION： The increased cumulative prevalence of OH in C/HCRVO patients indicates that OH is a risk factor for the appearance of venous occlusion. Patients with OH associated with C/HCRVO must be considered to be at high risk for conversion to POAG. Treatment with OH medications prevented conversion to POAG during the 3-year follow-up.

关键词： ocular hypertension acute central/hemicentral retinal vein occlusion intraocular pressure primary openangle glaucoma risk factor

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Neuroprotective Effect of Compound Anisodine in a Mouse Model with Chronic ocular hypertension

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Chinese Medical Journal 2015年第19期128卷 2652-2657页

作者： Wen-Dong Liu Lan-Lan Chen Ce-Ying Shen Li-Bin Jiang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China

Background：Compound anisodine （CA） is a compound preparation made from hydrobromide anisodine and procaine *** former is an M-choline receptor blocker with the function of regulating the vegetative nervous system,improving microcirculation,and so *** latter is an antioxidant with the activities *** study aimed to investigate the potential neuroprotection of CA,which affects the degeneration of the retinal ganglion cells （RGCs） in an animal model with chronic ocular ***：Female C57BL/6J mice （n =24） were divided randomly into four groups：Normal control group without any treatment （Group A,n =6）;CA control group with feeding the CA solution （Group B,n =6）;microbeads （MBs） control group with injecting MB into the anterior chamber （Group C,n =6）;CA study group with MB injection and with feeding the CA solution （Group D,n =6）.Intraocular pressure （IOP） was measured every 3 days after MB *** the 21st day,neurons were retrograde-labeled by Fluoro-Gold （FG）.Animals were sacrificed on the 27th *** flat mounts were stained immunohistologically by β-Ⅲ-***-retrograde-labeled RGCs,β-Ⅲ-tubulin-positive RGCs,and β-Ⅲ-tubulin-positive nerve fibers were ***：Mice of Groups C and D expressed the incidence of consistent IOP elevation,which is above the IOP level of Group A with the normal *** is no significant difference in IOP between Groups A and B （P ＞ 0.05）.On the 27th day,there were distinct loss in stained RGCs and nerve fibers from Groups C and D compared with Group A （all P ＜ 0.00l）.The quantity was significantly higher in Group D as compared to Group C （all P ＜ 0.00l） but lower than Group A （all P ＜ 0.001）.There was no significant difference in the quantity of RGCs and nerve fibers between Groups A and B （all P ＞ 0.05）.Conclusions：These findings suggest that CA plays an importantly neuroprotective role on RGCs in a mouse model with chronic ocular hypertension.

关键词： Compound Anisodine Glaucoma Neuroprotection ocular hypertension

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c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice:a possible target to reduce ganglion cell apoptosis

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Neural Regeneration Research 2015年第3期10卷 432-437页

作者： Yue He Jie Chen Shu-guang Zhang Yuan-sheng Yuan Yan Li Hong-bin Lv Jin-hua Gan Department of Ophthalmology the Affiliated Hospital of Luzhou Medical College Department of Rheumatology and Immunology the Affiliated Hospital of Luzhou Medical College Department of Ophthalmology the Second People’s Hospital of Zhengzhou City Department of Ophthalmology the First Affiliated Hospital of Kunming Medical University

Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase （JNK） participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore a possible mechanism of action of JNK signaling pathway in glaucoma-induced retinal optic nerve damage. We established a mouse model of chronic ocular hypertension by reducing the aqueous humor followed by pho- tocoagulation using the laser ignition method. Results showed significant pathological changes in the ocular tissues after the injury. Apoptosis of retinal ganglion cells increased with increased intraocular pressure, as did JNK3 mRNA expression in the retina. These data indicated that the increased expression of JNK3 mRNA was strongly associated with the increase in intraocular pressure in the retina, and correlated positively with the apoptosis of retinal ganglion cells.

关键词： nerve regeneration ocular hypertension ]NK3 retinal ganglion cell glaucoma laserphotocoagulation intraocular pressure neural regeneration

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Ultrasound biomicroscopic evaluation of anterior segment cysts as a risk factor for ocular hypertension and closure angle glaucoma

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 515-520页

作者： Abdurrahim Dusak Mehmet Baykara Guven Ozkaya Cuneyt Erdogan Hikmet Ozcetin Ercan Tuncel Department of Radiology School of MedicineUludag University Department of Ophthalmology School of MedicineUludag University Department of Statistics School of MedicineUludag University

AIMTo investigate the relationship between the ultrasound biomicroscopic (UBM) features of anterior-segment cysts (ASCs) and increased intraocular pressure (IOP) as a risk factor for closed-angle glaucoma (CAG).

关键词： anterior-segment cyst ocular hypertension closed-angle glaucoma intraocular pressure ultrasound biomicroscopy

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Bimatoprost/timolol fixed combination(BTFC) in patients with primary open angle glaucoma or ocular hypertension in Greece

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 69-75页

作者： Tryfon G.Rotsos Vasso G.Kliafa Kevin J.Asher Dimitrios Papaconstantinou 1st Department of Ophthalmology University of Athens Department of Regulatory Affairs Nexus Medicals S.A. Department of Regional Scientific Services Allergan Holdings Limited

AIM：To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%（BTFC）in patients in Greece with primary open angle glaucoma（POAG）or ocular hypertension（OHT）whose previous therapy provided insufficient lowering of intraocular pressure（IOP）.·METHODS：A multicenter,prospective,open-label,non-interventional,observational study of the use of BTFC in clinical practice was conducted at 41 sites in *** primary endpoint was the reduction in IOP from baseline at study end,approximately 12wk after initiation of BTFC therapy.·RESULTS：A total of 785 eligible patients were enrolled in the study and 97.6%completed the *** mean±SD IOP reduction from baseline at 12wk after initiation of BTFC was 6.3±2.8 mm Hg（=764;〈0.001）.In patients（=680）who replaced their previous IOP-lowering monotherapy（a single drug,or a fixed combination of 2drugs in a single ophthalmic drop）with once-daily BTFC,the mean±SD IOP reduction from baseline at 12wk was 6.2±2.8 mm Hg（〈0.001）.IOP was reduced from baseline in 99.2%of patients,and 58.0%of patients reached or exceeded their target *** mean IOP reductions were observed regardless of the previous *** was well tolerated,with 96.0%of patients who completed the study rating the tolerability of BTFC as＂good＂or＂very good.＂Adverse events were reported in 8.3%of patients;only 0.6%of patients discontinued the study due to adverse events.·C ONCLUSION：In clinical practice in Greece,BTFC is well tolerated and effectively lower the IOP in patients with POAG or OHT who requires additional IOP lowering on their previous therapy.

关键词： fixed combination glaucoma intraocularpressure ocular hypertension primary open angle glaucoma prostaglandin prostamide timolol

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The assessment of structural changes on optic nerve head and macula in primary open angle glaucoma and ocular hypertension

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1631-1637页

作者： Kenan Dagdelen Emrah Dirican Department of Ophthalmology Eskisehir Yunus Emre State Hospital Department of Ophthalmology Konya Training and Research Hospital

AIM：To assess morphological changes in macula, retinal nerve fiber layer （RNFL） and optic nevre head （ONH） of cases with primary open angle glaucoma （POAG） and ocular hypertension （OH） with spectral domain optic coherence tomography （OCT）.METHODS：This study included 109 eyes from 62 POAG patients, 50 eyes from 30 OH patients, and 101 eyes from 53 healthy volunteers. Data gained by OCT were compared with perimetry indexes. ONH, RNFL and macula analysis were performed for all subjects. Rim area, disc area,average cup/disc （C/D） ratio, vertical C/D ratio, cup volume data were recorded during ONH analysis. Average RNFL thickness and the thickness of four quadrants （superior,inferior, nasal and temporal） was established in *** total, nine macular quadrants involving the foveal region mentioned in the Early Treatment Diabetic Treatment Study（ETDRS） template were measured, and average macular thickness and macular volume data were recorded during macula analysis. Differences between groups were evaluated with the one-way ANOVA test. Tukey’s multiple comparison test was performed to detect difference between ***-operating characteristic （ROC） analysis was done for early stage POAG patients to establish sensitivity and specificity of chosen parameters in early stage *** under the receiver operating characteristic （AUROC）values were calculated to compare ROC ***：Statistically significant differences were found in all ONH parameters, except optic disc area. Neuroretinal rim area was identified as the parameter with the highest difference between groups （F=21.72, P〈0.05）. The highest correlation between ONH parameters and perimetry was observed at neuroretinal rim region （r=0.487）. Inferior RNFL thickness was established as the parameter with the highest difference between groups among RNFL parameters. In the mean of all glaucoma patients, the highest correlation between data handled with OCT and mean deviation was observed in RNFL thickness.

关键词： glaucoma ocular hypertension optic coherence tomography

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Mid-term results of patterned laser trabeculoplasty for uncontrolled ocular hypertension and primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1199-1204页

作者： Gustavo Espinoza Yuly Andrea Castellanos-Castellanos Angelica Pedraza-Concha Ignacio Rodriguez-Una Maria Fernanda Acuna Juan Camilo Parra Centro Oftalmologico Virgilio Galvis BucaramangaSantander 681004Colombia Fundacion Oftalmologica de Santander BucaramangaSantander 681004Colombia Universidad Industrial de Santander BucaramangaSantander 680002Colombia Instituto Oftalmologico Fernandez-Vega Universidad de OviedoOviedo 33012Spain

AIM:To describe the safety and efficacy of patterned laser trabeculoplasty(PLT)as an adjunctive treatment in primary open angle glaucoma(POAG)and ocular hypertension(OHT)after 18-month follow-up in Hispanic ***:A single-center,retrospective study was *** patients with OHT or POAG undergoing PLT from June 2016 to August 2016 were included in the *** parameters were intraocular pressure(IOP),the number of IOP-lowering medications,best corrected visual acuity(BCVA),laser parameters and postoperative adverse *** efficacy outcome measures were the proportion of eyes achieving an IOP reduction≥20%at 18 mo versus baseline medicated IOP or a reduction in the number of medications while maintaining IOP ***:From 40 PLT-treated eyes(mean baseline IOP 20.3±1.7 mm Hg),24 patients were analyzed(age 63.4±7.3 y).The mean IOP reductions from baseline across visits(months 1,3,6,9,12,and 18)ranged from 14.1%to 20.8%.Success rate after 18-month follow-up was 61.7%with a mean IOP of 16±3.2 mm Hg(P<0.001).The number of glaucoma IOP-lowering medications per eye(preoperative 2.1±1.1 and postoperative 2.3±1.1,P=0.86)and the mean BCVA(preoperative 0.10±0.22 and postoperative 0.11±0.22 logMAR,P=0.42)remained *** events comprised transitory IOP spikes in 4 eyes(10%)and peripheral anterior synechiae in 7 eyes(17.5%).CONCLUSION:Mid-term results of PLT show that this procedure may be an efficacious and safe technique to approach medically uncontrolled OHT or POAG patients.

关键词： glaucoma intraocular pressure ocular hypertension patterned laser trabeculoplasty

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Relationship between intraocular pressure and parameters of obesity in ocular hypertension

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 794-800页

作者： Min Won Ahn Ji Woong Lee Jong Hoon Shin Jong Soo Lee Busan Sungmo Eye Hospital Busan 48064Korea Department of Ophthalmology Pusan National University College of Medicine and Medical Research Institute of Pusan National University HospitalBusan 49241Korea Department of Ophthalmology Pusan National University Yangsan HospitalYangsan 50612Korea

AIM:To evaluate the correlation between intraocular pressure(IOP)and various obesity-related health factors in patients with ocular hypertension in ***:A total of 40850 subjects underwent age,sex,body weight,and height assessments and automated multiphasic tests,including non-contact tonometry,automated perimetry,fundus photography,systolic/diastolic blood pressure measurement,and evaluation of obesity-related health parameters such as obesity index,body mass index(BMI),a body shape index(ABSI),and waist-to-height ratio(WtHR).Subjects were divided into ocular hypertension group and normal IOP group according to IOP after matching of age and ***:Of 40850 participants,1515(3.7%)had ocular hypertension,and 1515 with normal IOP were selected as controls using propensity score *** mean IOP of control group was 15.3±2.3 mm Hg,compared with 23.3±1.6 mm Hg in ocular hypertension ***,obesity index,BMI,and WtHR in the ocular hypertension group were significantly higher than in the normal IOP group(Pocular hypertension was positively correlated with obesity index(P=0.027)and BMI(P=0.016),whereas IOP of control was positively correlated with blood pressure(Pocular hypertension according to multiple regression ***:Among various obesity-related health parameters,obesity index is the best indicator for further increase in IOP in ocular hypertension group.

关键词： intraocular pressure ocular hypertension body mass index body shape index waist-to-height ratio

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