c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice:a possible target to reduce ganglion cell apoptosis

作     者：Yue He Jie Chen Shu-guang Zhang Yuan-sheng Yuan Yan Li Hong-bin Lv Jin-hua Gan 

作者机构：Department of Ophthalmologythe Affiliated Hospital of Luzhou Medical College Department of Rheumatology and Immunologythe Affiliated Hospital of Luzhou Medical College Department of Ophthalmologythe Second People’s Hospital of Zhengzhou City Department of Ophthalmologythe First Affiliated Hospital of Kunming Medical University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第3期

页      面：432-437页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100212[医学-眼科学] 10[医学] 

基　　金：supported by grants from the Youth Foundation of Luzhou Medical College of Luzhou City of Sichuan Province of China,No.108 the Talent Fund of the Affiliated Hospital of Luzhou Medical College of Luzhou City of Sichuan Province of China,No.43 

主　　题：nerve regeneration ocular hypertension ]NK3 retinal ganglion cell glaucoma laserphotocoagulation intraocular pressure neural regeneration 

摘      要：Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase （JNK） participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore a possible mechanism of action of JNK signaling pathway in glaucoma-induced retinal optic nerve damage. We established a mouse model of chronic ocular hypertension by reducing the aqueous humor followed by pho- tocoagulation using the laser ignition method. Results showed significant pathological changes in the ocular tissues after the injury. Apoptosis of retinal ganglion cells increased with increased intraocular pressure, as did JNK3 mRNA expression in the retina. These data indicated that the increased expression of JNK3 mRNA was strongly associated with the increase in intraocular pressure in the retina, and correlated positively with the apoptosis of retinal ganglion cells.