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The art of nomograms

Eye and Vision 2018年第1期5卷 11-23页

作者： Samuel Arba Mosquera Diego de Ortueta Shwetabh Verma Recognized Research Group in Optical Diagnostic Techniques University of ValladolidValladolidSpain SCHWIND eye-tech-solutions Mainparkstr.6-10D-63801 KleinostheimGermany Department of Ophthalmology and Sciences of Vision University of OviedoOviedoSpain Augenzentrum Recklinghausen RecklinghausenGermany Experimental Radiation Oncology University Medical Center MannheimHeidelberg UniversityHeidelbergGermany Interdisciplinary Center for Scientific Computing(IWR) Heidelberg UniversityHeidelbergGermany Central Institute for Computer Engineering(ZITI) Heidelberg UniversityHeidelbergGermany

Background:To retrospectively analyse strategies for adjusting refractive surgery plans with reference to the preoperative manifest ***:We constructed seven nomograms based on the refractive outcomes(sphere,cylinder,axis[SCA])of 150 consecutive eyes treated with laser in situ keratomileusis for myopic *** limited the initial data to the SCA of the manifest *** nomograms were based on the strategy:if for x diopters(D)of attempted metric,y D is achieved;we can reverse this sentence and state for achieving y D of change in the metric,x D will be *** effects of the use of plus or minus astigmatism notation,spherical equivalent,sphere,principal meridians notation,cardinal and oblique astigmatism,and astigmatic axis were ***:All nomograms detected subtle differences in the spherical component(pnomograms 5 and 7(using power vectors)and 6(considering axis shifts)detected significant astigmatic differences(nomogram 5,pnomograms;differences of~0.25 D in the proposals for sphere or cylinder were not *** nomograms suggested minor improvements versus actual observed outcomes,with no clinically relevant differences among ***:All nomograms anticipated minor improvements versus actual observed outcomes without clinically relevant differences among *** minimal uncertainties in determining the manifest refraction(~0.6 D)are the major limitation to improving the accuracy of refractive surgery nomograms.

关键词： Refraction nomograms Refractive outcomes Sphere Cylinder

Risk factors,prognostic predictors,and nomograms for pancreatic cancer patients with initially diagnosed synchronous liver metastasis

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 128-142页

作者： Bi-Yang Cao Fang Tong Le-Tian Zhang Yi-Xin Kang Chen-Chen Wu Qian-Qian Wang Wei Yang JingWang Department of Radiation Oncology First Medical Center of Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China

BACKGROUND Liver metastasis(LM)remains a major cause of cancer-related death in patients with pancreatic cancer(PC)and is associated with a poor ***,identifying the risk and prognostic factors in PC patients with LM(PCLM)is essential as it may aid in providing timely medical interventions to improve the prognosis of these ***,there are limited data on risk and prognostic factors in PCLM *** To investigate the risk and prognostic factors of PCLM and develop corresponding diagnostic and prognostic *** Patients with primary PC diagnosed between 2010 and 2015 were reviewed from the Surveillance,Epidemiology,and Results *** factors were identified using multivariate logistic regression analysis to develop the diagnostic *** least absolute shrinkage and selection operator Cox regression model was used to determine the prognostic factors needed to develop the prognostic *** performance of the two nomogram models was evaluated using receiver operating characteristic(ROC)curves,calibration plots,decision curve analysis(DCA),and risk subgroup *** Kaplan-Meier method with a logrank test was used for survival *** We enrolled 33459 patients with PC in this *** them,11458(34.2%)patients had LM at initial *** at diagnosis,primary site,lymph node metastasis,pathological type,tumor size,and pathological grade were identified as independent risk factors for LM in patients with ***>70 years,adenocarcinoma,poor or anaplastic differentiation,lung metastases,no surgery,and no chemotherapy were the independently associated risk factors for poor prognosis in patients with *** C-index of diagnostic and prognostic nomograms were 0.731 and 0.753,*** two nomograms could accurately predict the occurrence and prognosis of patients with PCLM based on the observed analysis results of ROC curves,calibration plots,and DCA *** prognostic nomogram could strati

关键词： Pancreatic neoplasms Neoplasm metastasis Liver Prognosis nomograms Surveillance,Epidemiology,and End Result program

Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy

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Chinese Journal of Cancer Research 2020年第2期32卷 186-196页

作者： Jun Luo Yuming Jiang Xinhua Chen Yuehong Chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036China

Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains *** study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction ***:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were *** first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were *** analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm ***≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM>5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 *** patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size>5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM>5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM *** the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,***:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more

关键词： Gastric cancer margin distance nomograms distal gastrectomy

Uroflowmetric analysis and derivation of nomograms for normal paediatric Indian population between 5 to 15 years of age

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Asian Journal of Urology 2022年第2期9卷 125-131页

作者： Abhay D.Mahajan Lakshman P.Singh Prashant P.Darakh Sandeep T.Bathe Martand G.Patil Arpit R.Sharma Mahatma Gandhi Mission Medical College and Hospital AurangabadMaharashtraIn

Objective:We aimed to established normal uroflowmetric values and subsequently derived nomograms of _(max)imum flow rate(Q_(max))and average flow rate(Q_(avg))against voided volume(VV)in children aged 5-15 years at our ***:A total of 440 children underwent uroflowmetric evaluation with no history of urological,renal,psychiatric,or neurological disorder between 5 and 15 years of *** subject data regarding Q_(max),Q_(avg),VV,time to Q_(max),and flow time,as well as age,sex,height,and weight were *** the 440 children,around 300(68.18%)children could produce a normal flow rate at VV of more than 50 *** the remaining 140(31.82%)children,50.00%voided less than 50 mL,and remaining 50.00%had abnormal voiding pattern,staccato or interrupted(21.43%each)and plateau or tower shaped(3.57%each).Cases were divided into two age groups(5-9 years and 10-15 years),and uroflowmetric analysis was done between boys and girls in both age groups to derive nomograms of Q_(avg) and Q_(max).Results:Q_(max) and Q_(avg) flow nomograms were plotted for boys and *** Q_(max) for boys was 16.68 mL/s and for girls 20.69 mL/*** mean Q_(avg) values were 11.04 mL/s and 8.60 mL/s for girls and boys,*** Q_(max) and Q_(avg) values were higher in *** were significant increases in flow rates with increasing age,body surface area,and VV in both ***:nomograms for Q_(max) and Q_(avg) may be a useful tool in evaluation of lower urinary tract disturbances in children.

关键词： Uroflowmetry nomograms Pediatric Voided volume Flow rate

Analysis of factors related to postpartum depression in pregnancyinduced hypertension syndrome patients and construction and evaluation of nomograms

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World Journal of Psychiatry 2023年第9期13卷 654-664页

作者： Jie-Wei Pan Gang Zhao Department of Obstetrics and Gynecology Huzhou Maternity and Child Health Care HospitalHuzhou 313000Zhejiang ProvinceChina

BACKGROUND It is positive to integrate and evaluate the risk factors for postpartum depression in patients with pregnancy-induced hypertension syndrome and to detect highrisk patients as early as possible,which has application value for the clinical development of personalized prevention programs and prognosis of *** To analyze factors related to postpartum depression in patients with pregnancyinduced hypertension and construct and evaluate a nomogram *** The clinical data of 276 patients with pregnancy-induced hypertension admitted to Huzhou Maternity and Child Health Care Hospital between January 2017 and April 2022 were retrospectively *** evaluated the depression incidence at 6 wk *** depression group included patients with postpartum depression,and the remainder were in the non-depression *** logistic regression analysis and the LASSO regression model were applied to analyze the factors related to postpartum depression in patients with pregnancyinduced *** that,a risk prediction model nomogram was constructed and *** Multivariate logistic regression analysis showed that vitamin A deficiency(VAD)during pregnancy and puerperium,family history of hypertension,maternal intestinal flora imbalance,eicosapentaenoic acid(EPA),and docosahexaenoic acid(DHA)were independent risk factors for postpartum depression in patients with pregnancy-induced hypertension(P<0.05).We constructed the nomogram model based on these five risk *** area under the curve,specificity,and sensitivity of the model in predicting postpartum depression in patients with pregnancy-induced hypertension was 0.867(95%confidence interval:0.828–0.935),0.676,and 0.889,*** average absolute error was 0.037(Hosmer-Lemeshow testχ2=10.739,P=0.217).CONCLUSION VAD during pregnancy and puerperium,family history of hypertension,maternal intestinal flora imbalance,EPA,and DHA affect postpartum depression in patients

关键词： Pregnancy-induced hypertension syndrome Postpartum depression Unhealthy emotions Related factors nomograms Evaluation

Prognostic nomograms on inflammatory markers in hepatitis B virus-related hepatocellular carcinoma patients who underwent hepatectomy

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Cancer Biology & Medicine 2018年第S1期15卷 9-10页

作者： Yifei Wang Shuling Chen Bin Li Zebin Chen Zhenwei Peng Ming Kuang Department of Liver Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Division of Interventional Ultrasound The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Clinical Trials Unit The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Objective:This study aims to develop prognostic nomograms based on inflammatory markers for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)***:Between November 2003 and December 2017,1,350HCC patients who were HBV surface antigen(HBsAg)positive and underwent curative hepatectomy were retrospectively collected from two medical centers.

关键词： Prognostic nomograms inflammatory

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膀胱癌的nomograms预测模型

国际外科学杂志 2011年第2期38卷 128-132页

作者：丁飞郝钢跃首都医科大学北京100069 华北电网有限公司北京电力医院泌尿外科北京100073 首都医科大学附属北京友谊医院泌尿外科北京100050

膀胱癌的自然病史存在显著变异性，这使得对个体患者进行预后评估显得十分重要。nomograms模型较其他模型具有更高的预测准确性和应用简便性，它可以提供准确的个体化风险评估，方便临床决策。nomograms模型被认为是预测膀胱癌患者预后... 详细信息

膀胱癌的自然病史存在显著变异性，这使得对个体患者进行预后评估显得十分重要。nomograms模型较其他模型具有更高的预测准确性和应用简便性，它可以提供准确的个体化风险评估，方便临床决策。nomograms模型被认为是预测膀胱癌患者预后的最准确、最具鉴别力的预测工具，具有广阔的发展前景。然而，这种模型也有其自身的不足，这需要更多的研究和新的预测因子来弥补。并且，在nomograms模型真正用于临床实践之前，需要更多的证据来证明这种模型能够改善患者的治疗效果。

关键词： nomograms 膀胱肿瘤泌尿学预后

Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes

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World Journal of Clinical Cases 2023年第5期11卷 1019-1030页

作者： Qi-Zhe Meng Yang Wang Bing Li Zhi Xi Ming Wang Jia-Qi Xiu Xiao-Peng Yang Department of Neurology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Lacunes are the manifestations of lacunar infarction which can lead many patients to the clinical outcome of disability or ***,the relationship between lacune burden,cognitive function and blood glucose fluctuation in patients with type 2 diabetes mellitus(T2DM)complicated with lacunes is not very *** To explore the correlation between glucose variability,lacune burden and cognitive function in patients with lacunes complicated with *** The clinical and imaging data of 144 patients with lacunes combined with T2DM were reviewed retrospectively.72 h continuous glucose monitoring was *** Montreal Cognitive Assessment was used to assess cognitive *** burden of lacunes was evaluated using magnetic resonance imaging *** logistic regression analysis was used to study the affecting the lacune load and cognitive impairment in *** predict the value of patients’cognitive impairment with lacunes complicated with T2DM,a receiver operating characteristic(ROC)curve and a nomogram prediction model were *** The standard deviation(SD)of the average blood glucose concentration,percentage coefficient of variation(%CV)and time of range(TIR)were significantly different between the low and the high load groups(P<0.05).The SD,%CV and TIR of the cognitive impairment group and non-cognitive impairment group were significantly different(P<0.05).SD(odds ratio(OR):3.558,95%confidence interval(CI):1.268-9.978,P=0.006),and%CV(OR:1.192,95%CI:1.081-1.315,P<0.05)were the risk factors for an increased infarct burden in lacunes patients complicated with ***(OR:0.874,95%CI:0.833-0.928,P<0.05)is a protective *** addition,an increased SD(OR:2.506,95%CI:1.008-6.23,P=0.003),%CV(OR:1.163,95%CI:1.065-1.270,P<0.05)were the risk factors for cognitive impairment in patients with lacunes complicated with T2DM,TIR(OR:0.957,95%CI:0.922-0.994,P<0.05)is a protective factor.A nomogram prediction model o

关键词： Blood glucose variability Lacunes Type 2 diabetes Cognitive impairment nomograms

Clinical diagnosis of severe COVID-19:A derivation and validation of a prediction rule

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World Journal of Clinical Cases 2021年第13期9卷 2994-3007页

作者： Ming Tang Xia-Xia Yu Jia Huang Jun-Ling Gao Fu-Lan Cen Qi Xiao Shou-Zhi Fu Yang Yang Bo Xiong Yong-Jun Pan Ying-Xia Liu Yong-Wen Feng Jin-Xiu Li Yong Liu Department of Critical Care Medicine Shenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Buddhism and Science Research Laboratory Centre of Buddhist StudiesThe University of Hong KongHong Kong 999077China Department of Critical Care Medicine Wuhan Third HospitalWuhan 433304Hubei ProvinceChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina Department of Pediatrics Wuhan Asia General HospitalWuhan 430022Hubei ProvinceChina Department of Critical Care Medicine Southern University of Science and Technology HospitalShenzhen 518055Guangdong ProvinceChina Department of Critical Care Medicine The Second People's Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Department of Critical Care Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Shenzhen Hospital Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND The widespread coronavirus disease 2019(COVID-19)has led to high morbidity and ***,early risk identification of critically ill patients remains *** To develop predictive rules at the time of admission to identify COVID-19 patients who might require intensive care unit(ICU)*** This retrospective study included a total of 361 patients with confirmed COVID-19 by reverse transcription-polymerase chain reaction between January 19,2020,and March 14,2020 in Shenzhen Third People’s *** logistic regression was applied to develop the predictive *** performance of the predictive model was externally validated and evaluated based on a dataset involving 126 patients from the Wuhan Asia General Hospital between December 2019 and March 2020,by area under the receiver operating curve(AUROC),goodness-of-fit and the performance matrix including the sensitivity,specificity,and precision.A nomogram was also used to visualize the *** Among the patients in the derivation and validation datasets,38 and 9 participants(10.5%and 2.54%,respectively)developed severe COVID-19,*** univariate analysis,21 parameters such as age,sex(male),smoker,body mass index(BMI),time from onset to admission(>5 d),asthenia,dry cough,expectoration,shortness of breath,asthenia,and Rox index<18(pulse oxygen saturation,SpO2)/(FiO2×respiratory rate,RR)showed positive correlations with severe *** multivariate logistic regression analysis,only six parameters including BMI[odds ratio(OR)3.939;95%confidence interval(CI):1.409-11.015;P=0.009],time from onset to admission(≥5 d)(OR 7.107;95%CI:1.449-34.849;P=0.016),fever(OR 6.794;95%CI:1.401-32.951;P=0.017),Charlson index(OR 2.917;95%CI:1.279-6.654;P=0.011),PaO2/FiO2 ratio(OR 17.570;95%CI:1.117-276.383;P=0.041),and neutrophil/lymphocyte ratio(OR 3.574;95%CI:1.048-12.191;P=0.042)were found to be independent predictors of *** factors were found to be significant risk f

关键词： COVID-19 Communicable diseases Clinical decision rules Prognosis nomograms