Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy

作     者：Jun Luo Yuming Jiang Xinhua Chen Yuehong Chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu Jun Luo;Yuming Jiang;Xinhua Chen;Yuehong Chen;Jhang Lopsang Gurung;Tingyu Mou;Liying Zhao;Guoqing Lyu;Tuanjie Li;Guoxin Li;Jiang Yu

作者机构：Department of General SurgeryNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Gastrointestinal SurgeryPeking University Shenzhen HospitalShenzhen 518036China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2020年第32卷第2期

页      面：186-196页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Grant of Wu Jieping Medical Funding(No.320.2710.1819) 

主　　题：Gastric cancer margin distance nomograms distal gastrectomy 

摘      要：Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains *** study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction ***:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were *** first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were *** analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm ***≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 *** patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM *** the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,***:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more