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nomifensine和Domperidone结合应用对高泌乳血症鉴别诊断的价值

上海第二医学院学报 1982年第2期 86-86页

作者：潘允平

Nomifénsime能抑制多巴胺的再吸收或刺激多巴胺释放,伕多巴胺的神经传递作用受到激活,而Domperidone是多巴胺受体阻滞剂,作者在同一病人中结合应用二种药物进行试验,认为对鉴别功能性和瘤肿性泌乳素血症有诊断价值。本文研究了41个病... 详细信息

Nomifénsime能抑制多巴胺的再吸收或刺激多巴胺释放,伕多巴胺的神经传递作用受到激活,而Domperidone是多巴胺受体阻滞剂,作者在同一病人中结合应用二种药物进行试验,认为对鉴别功能性和瘤肿性泌乳素血症有诊断价值。本文研究了41个病人均有血浆泌乳素(简称PRL)升高,其中女38例,几乎全部有闭径或月径失调,男性3例有阳萎无泌乳。

关键词：高泌乳血症病人 nomifensine Domperidone 结合应用

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Attenuated inhibition of medium spiny neurons participates in the pathogenesis of childhood depression

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Neural Regeneration Research 2014年第10期9卷 1079-1088页

作者： Dan Liu Linghan Hu Junqi Zhang Ping Zhang Shengtian Li Bio-X Institutes Shanghai Jiao Tong University

Accumulating evidence suggests that the nucleus accumbens, which is involved in mechanisms of reward and addiction, plays a role in the pathogenesis of depression and in the action of anti-depressants. In the current study, intraperitoneal injection of nomifensine, a dopamine reuptake inhibitor, decreased depression-like behaviors in the Wistar Kyoto rat model of depression in the sucrose-preference and forced swim tests. nomifensine also reduced membrane excitability in medium spiny neurons in the core of the nucleus accumbens in the childhood Wistar Kyoto rats as evaluated by electrophysiological recording. In addition, the expression of dopamine D2-like receptor mRNA was downregulated in the nucleus accumbens, striatum and hippocampus of nomifensine-treated childhood Wistar Kyoto rats. These experimental ifndings indicate that impaired inhibition of medium spiny neurons, mediated by dopamine D2-like receptors, may be involved in the formation of depression-like behavior in childhood Wistar Kyoto rats, and that nomifensine can alleviate depressive behaviors by reducing medium spiny neuron membrane excitability.

关键词： nerve regeneration brain injury neurophysiology MSNs dopamine D2-like receptors childhood depression Wistar Kyoto rats nucleus accumbens excitatory inhibition neural plasticity nomifensine NSFC grant neural regeneration

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The effects of embedding catgut in acupoints on behaviors of WKY rat,a putative animal model of depression

The effects of embedding catgut in acupoints on behaviors of...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ting WANG~(1,2),Chun-Lei DING~2,Bu-Yi WANG~2,Yang GUO~2,Shou-Shan MA~2,Sheng-Tian LI~(2,*) 1 Kao(China)Research & Development Center,No.623 Ziri Rd.,Minhang District,Shanghai 200241,China 2 School of Life Sciences & Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China

＜正＞Objective In China,acupuncture has been used for treatment of depressive disorders,while the evaluations of therapeutic effects have been lack of experimental *** catgut in acupoints（ECP） is an alternative method of acupuncture that continuously stimulates the acupoints via producing physiological and biochemical *** to hand-acupuncture or electro-acupuncture,ECP is more easily to perform in animals because which can be conducted under *** the current study we investigated the effect of ECP on Wistar Kyoto（WKY） rats,a genetic animal model for depressive *** WKY rats were treated with ECP once per week at GV20（Bai Hui）,bilateral BL15（Xin Shu）,BL23（Shen Shu）,PC6（Nei Guan）,ST36（Zu San Li） and SP6（San Yin Jiao） under *** depressive,anxiety-like and spatial learning behaviors were examined by behavior test battery including open field test,forced swim test,Morris water maze test,elevated plus maze test and light/dark transition *** Compared with sham ECP treatment,ECP treatment significantly increased total distance traveled and time stayed in the central area in open field test and the time spent in the target quadrant in Morris water maze *** These findings indicate that ECP treatment can improve depressive,anxietylike and spatial learning behaviors of WKY rats.

关键词： acupuncture depression anxiety spacial learning and memory nomifensine

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