The effects of embedding catgut in acupoints on behaviors of WKY rat,a putative animal model of depression
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学]
关 键 词：acupuncture depression anxiety spacial learning and memory nomifensine
摘 要：正Objective In China,acupuncture has been used for treatment of depressive disorders,while the evaluations of therapeutic effects have been lack of experimental *** catgut in acupoints（ECP） is an alternative method of acupuncture that continuously stimulates the acupoints via producing physiological and biochemical *** to hand-acupuncture or electro-acupuncture,ECP is more easily to perform in animals because which can be conducted under *** the current study we investigated the effect of ECP on Wistar Kyoto（WKY） rats,a genetic animal model for depressive *** WKY rats were treated with ECP once per week at GV20（Bai Hui）,bilateral BL15（Xin Shu）,BL23（Shen Shu）,PC6（Nei Guan）,ST36（Zu San Li） and SP6（San Yin Jiao） under *** depressive,anxiety-like and spatial learning behaviors were examined by behavior test battery including open field test,forced swim test,Morris water maze test,elevated plus maze test and light/dark transition *** Compared with sham ECP treatment,ECP treatment significantly increased total distance traveled and time stayed in the central area in open field test and the time spent in the target quadrant in Morris water maze *** These findings indicate that ECP treatment can improve depressive,anxietylike and spatial learning behaviors of WKY rats.