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nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

World Journal of Gastroenterology 2012年第4期18卷 331-339页

作者： Andreja Vujanac Vladimir Jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric Department of Physiology Faculty of MedicineUniversity of Kragujevac Department of Gastroenterology and Echosonography Unit Clinical Centre of Belgrade Internal Clinic Clinical Centre "Kragujevac"Faculty of MedicineUniversity of Kragujevac Department of Physical Medicine and Rehabilitation Faculty of MedicineUniversity of Kragujevac Institute of Medical Physiology Belgrade University School of Medicine

AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal ***:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the *** di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler ***-section area,portal flow and index of vascular resistance were *** collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were ***-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) ***:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate *** O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid *** blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood ***:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension.

关键词： Portal hypertension Endothelium nitroglycerine Oxidative stress Portal vein haemodynamics

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Effects of nitroglycerine on Erythrocyte Rheology:A Novel Mechanism to Explain the Enhancement of Nutrient Blood Flow to Ischemic Zones

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South China Journal of Cardiology 2007年第3期8卷 138-146页

作者： D.Elizabeth Le Sanjiv Kaul Cardiovascular Division Oregon Health and Science UniversityPortland

Objectives nitroglycerine (NTG) enhances coronary blood flow to compromised myocardium is important in relieving ischemia. However, the mechanism for this increase in myocardial blood flow (MBF) is not well defined. In small vessels and capillaries, relative blood viscosity plays a very important role in determining myocardial vascular resistance (MVR). MVR reduce is due partly to the increase in negative charge of erythrocyte surface. We therefore hypothesized that the enhancement of nutrient blood flow to zones of myocardial ischemia during NTG is partly secondary to reduced MVR and blood flow viscosity. The latter is affected by the negative charge of erythrocyte surface. Methods 6 dogs with LAD flow-limiting stenosis (group 1) and 6 dogs with LAD flow-limiting stenosis and LCx occmusion (group 2) were studied. At baseline and during intracoronary infusions of NTG (0.3-0.6 μg·kg-1·min-1), hemodynamics, MBF (mL·min-1·g-1), whole blood viscosity (WBη, mPa. S), elongation index (EI), eletrophoretic mobility of erythocytes (EME, [μ.s-1)/(***-1)]) and percent wall thickening (%WT) were determined. MVR was calculated using driving pressure/MBF. Results As compared to baseline, no changes in hemodynamics were seen during NTG. MBF increased and MVR decreased significantly in normal bed, the central 25% and the entire of stenosed bed (P<0.05), with a decrease in WBη in both group 1 and group 2 dogs (18.6±9.7 % and 19.2±14.5 %, respectively). However, the % decrease in WBη was proportioned to the % increase in MBF or the % decrease in MVR only in the central 25% of stenosed bed (r=0.87, P<0.001), but not in the entire stenosed bed and normal bed. EI did not show statistically significant differences between during NTG and at baseline, but EME did increase. And the % decrease in WBη during NTG was related to the % increase in EME (r=0.83, P=0.01). Conclusions NTG reduced myocardial vascular resistance and blood viscosity due to the change of negative charge of erythrocyte

关键词： nitroglycerine myocardial blood flow myocardial vascular resistance whole blood viscosity erythrocyte rheology

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Joint Effects of Mexidol and nitroglycerine on Nitric Oxide Formation in Animal Liver Tissues

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American Journal of Molecular Biology 2021年第3期11卷 73-82页

作者： Taasilkan Zhumabaeva Zoya Kuropteva Zhoomart Moldaliev Nazgul Zhumabaeva Amanai Kadyrbaeva Nurbek Bopoev Zhypargul Abdullaeva Department of Natural Sciences Osh State University Osh Kyrgyzstan Institute of Biochemical Physics Russian Academy of Sciences Moscow Russia Department of Medicine Kyrgyz-Turkish University Manas Bishkek Kyrgyzstan Department of Hospital Therapy Zhalal-Abad State University Zhalal-Abad Kyrgyzstan International Hope School Bangladesh of Gulshan Branch Dhaka Bangladesh Science and Research Department Osh State University Osh Kyrgyzstan

This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units;produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes.

关键词： nitroglycerine Liver Tissue Nitric Oxide Mexidol Joint Effect EPR Spectra

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Fabrication and thermal decomposition of glycidyl azide polymer modified nitrocellulose double base propellants

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Science China Chemistry 2016年第4期59卷 472-477页

作者： Benbo Zhao Tianfu Zhang Zhen Ge Yunjun Luo School of Materials Science and Engineering Beijing Institute of Technology

Glycidyl azide polymer （GAP） with the advantages of non-volatility and excellent thermal stability is a candidate as a re- placement for nitroglycerine （NG） in a double base propellant. The GAP-NC double base propellants were formulated with GAP and nitrocellulose （NC） fibers. Tensile test and SEM characterization indicated that GAP-NC propellants had a homoge- neous structure. Thermogravimetric analysis of GAP-NC propellants revealed that the onset decomposition temperature reached a high level ranging from 192.9 to 194.6 ℃, which indicated that the substitution of NG with GAP contributed to the safe storage and process operations for double base propellant. The result analysis of decomposition products of GAP-NC propellants showed that the main gas decomposition products of the propellants were NO, NO〉 CO, CO2, NH3, CH4, HCN, N2 CH20 and C2H40. The thermal decomposition process of the specimens was proposed.

关键词： glycidyl azide polymers (GAP) nitrocellulose double base propellant nitroglycerine thermal decomposition

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Effect of inhalation of nebulized NO donor substance on acute hypoxic lung injury in newborn piglets

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Chinese Medical Journal 2008年第17期121卷 1622-1626页

作者： XIA Hong-ping HUANG Guo-ying ZHU Jian-xing SUN Bo Department of Paediatrics Children's Hospital of Fudan University Shanghai Medical College Shanghai 200032 China Department of Neonatalogy Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China

Background Birth asphyxia may result in multiple organ dysfunction such as lung injury. Inhalation of nebulized nitric oxide precursor can selectively reduce pulmonary hypertension. However, it is unknown whether such precursors can alleviate lung injury induced by hypoxia. We evaluated the effect of inhalation of nebulized nitroglycerine and sodium nitroprusside on acute hypoxic lung injury in newborn piglets. Methods Acute hypoxic lung injury was induced by inspiring 10% 02 for 1 hour. Twenty-four anaesthetized and mechanically ventilated piglets （5-7 days old） were randomly divided into four groups：（1） group S, not hypoxic; （2） group C, nebulized saline after hypoxia; （3） group NTG, nebulized nitroglycerine after hypoxia; （4） group SNP, nebulized sodium nitroprusside after hypoxia, Respiratory dynamic compliance and resistance of respiratory system were recorded at baseline, 0.5 hour and 1 hour of hypoxia; then 0.5 hour, 1 hour, 3 hours and 5 hours following hypoxia. After nebulization, arterial blood was collected for measuring methaemoglobin and nitrate/nitrite levels. Right lung tissue, wet-dry ratio and myeloperoxidase level were determined. White blood cell count （WBC）, total surfactant phospholipids （TPL） and disaturated phosphatidyl choline （DSPC） of the bronchoalveolar lavage fluid （BALF） were calculated. Left lungs were used for examining pathological changes. Results No significant difference was observed in respiratory dynamic compliance, resistance of respiratory system, wet-dry ratio, levels of methaemoglobin and nitrate/nitrite after nebulization, TPL or DSPC/TPL among four groups. WBC in BALF in groups NTG and SNP significantly decreased as compared with group C： similarly for myeloperoxidase level in lung tissue. Lung histological findings showed infiltration of neutrophils in groups NTG and SNP decreased significantly as compared with group C. Conclusion Inhalation of nebulized nitroglycerine or sodium nitroprusside can alleviate the infiltratio

关键词： hypoxia newborn nitric oxide donor nitroglycerine sodium nitroprusside

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Prevalence and characteristics of myocardial bridging in coronary angiogram data from consecutive 5525 patients

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Chinese Medical Journal 2009年第6期122卷 632-635页

作者： QIAN Ju-ying ZHANG Feng DONG Min MA Jian-ying GE Lei LIU Xue-bo FAN Bing WANG Qi-bing CUI Shan-jing GE Jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China

Background Large discrepancy of the incidence of myocardial bridging （MB） has been reported either among the postmortem studies or among the studies with coronary angiogram. This study was to investigate the prevalence of MB in large number of coronary angiograms and the angiographic characteristics of MB.Methods A total of 5525 consecutive patients who underwent first diagnostic coronary angiography from January 2003 to March 2006 in Zhongshan Hospital were enrolled in this study. MB was diagnosed when the angiographical ＂milking effect＂, defined as the systolic compression and complete or partly release of the compression in diastole, was seen in the epicardial coronary arteries. Angiography was routinely repeated after intracoronary injection of 200 pg nitroglycerin. The systolic compression and length of MB were compared before and after the administration of nitroglycerin and also before and after stent implantation in patients with significant stenosis in segment proximal to the MB.Results Among 5525 patients, MBs were found in a total of 888 patients angiographically with the prevalence of 16.1%. Atherosclerotic lesions were found more often in the segment proximal to the MB with 344/854 （40.3%） patients than in the segment distal to the MB with 47/854 （5.5%）（P 〈0.01）. The systolic compression （（43.3±13.7）% at baseline vs （54.2±14.0）% after nitroglycerine） and the average length （（20.9±7.5） mm at baseline vs （22.7±8.0） mm after nitroglycerine） of the MB segment were increased after intracoronary injection of nitroglycerin （both P 〈0.01）. Stent implantation was performed in 88 patients with significant stenosis in the segment proximal to the MB. The systolic compression and the length of the MB segment were increased after stenting compared with those before stenting （systolic compression, （49.4±14.6）% at baseline vs （57.3±12.3）% after stenting, and length of MB, （19.5±6.1） mm at baseline vs （21.8±6.3） mm after stenting, P 〈0.01）.Conclusions MB was a fr

关键词： myocardial bridging coronary angiography prevalence nitroglycerine stent

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“Dermal Nitroglycerin Patch” in Treatment of Preterm Labour

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Journal of Biosciences and Medicines 2015年第11期3卷 82-90页

作者： Kunjan Shah B. D. Gupta Raksha Sharma NIMS Jaipur Rajasthan India

Although preterm birth is the delivery before 37 + 0 weeks of gestation, the majority of prema-turity-related complications occur before 33 + 0 weeks of gestation. The need of today is to select the best agent out of the broad spectrum of available tocolytic agents, for providing maximum benefit to unfortunate sufferers of prematurity. The study aims to assess the role of “Dermal Nitroglycerin Patch” in treatment of preterm labour. Method: Study conducted in Department of Obstetrics & Gynecology, NIMS Medical College & Hospital, Jaipur from July 2014-December 2014. A prospective randomized study of 50 women of preterm labor was enrolled after informed consent. Patients were given dermal nitroglycerin patch as tocolytic agent according to study protocol. Result: 1) Results of NTG PATCH are comparable with other tocolytic drugs in terms of successful tocolysis;2) Maternal and fetal outcome is favourable in cases of NTG PATCH USE in preterm labour;3) Side effect profile was also better with NTG Patch. Conclusion: This randomized prospective study lends support to the proportion that Transdermal nitroglycerine (NTG Patch) may be promising safe, effective, well tolerated, cost effective and non invasive method of tocolysis.

关键词： Transdermal nitroglycerine (NTG Patch) Preterm Labor

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Nitroglycerin reduces augmentation index and central blood pressure independent of effects on cardiac preload

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Journal of Pharmaceutical Analysis 2009年第2期21卷 114-119页

作者： Mike Saddon Karen McNeil Philip Chowienczyk Cardiovascular Division King's College London School of MedicineSt Thomas' Hospital

Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compared effects of NTG with those of lower body negative pressure (LBNP). Hemodynamic measurements were made at rest,during LBNP (10,20 and 30 mmHg,each for 15 min) and after NTG (10,30 and 100 μg/min,each dose for 15 min) in ten healthy volunteers. Cardiac pre-load,stroke volume and cardiac output were assessed by echocardiography. Central pressure augmentation and central systolic pressure were obtained by radial tonometry using a transfer function. Results LBNP (20 mmHg) and NTG (30 μg/min) reduced pre-load (as measured by the peak velocity of the S wave in the superior vena cava) to a similar degree [by (26.8±3.8)% and (23.9±3.4)%,respectively]. Compared to LBNP,NTG reduced systemic vascular resistance [by (32.9±7.5)%,P<0.01],decreased peripheral and central pressure augmentation [by (20.8±3.4)% units and (12.9±2.9)% units,respectively,each P<0.01]. Conclusion These results suggest that a reduction in pre-load does not explain reduction in pressure augmentation and central systolic blood pressure by NTG and that these effects are mediated through arterial dilation.

关键词： augmentation index central blood pressure nitroglycerine cardiac preload lower body negative pressure

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