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Chinese Journal of Polymer Science 2019年第4期37卷 401-408,I0007页

作者： Lei-Jing Liu Wen Liu Guang Jia Zhi-Yuan Wu Bin Xu Jun Qian Wen-Jing Tian State Key Lab for Supramolecular Structure and Materials Jilin University State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchJORCEP (Sino-Swedish Joint Research Center of Photonics)Zhejiang University

Near-infrared(nir) nanoparticles(NPs) based on fluorescence resonance energy transfer(FRET) were prepared by coencapsulation of a red aggregation-induced emission(AIE) molecule, 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile(TB), and a commercial nir fluorescence dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide)(nir775) with an amphiphilic polymer poly(styrene-co-maleic anhydride)(PSMA). The surface of the NPs, PSMA@TB/nir775, was modified with poly(ethylene glycol)(PEG) to increase the in vivo biocompatibility of the NPs. The PSMA@TB/nir775 NPs showed a strong nir(780 nm) narrow emission and excellent two-photon absorption property. Moreover, the NPs exhibited good monodispersity, stability, and low *** the excitation of a 1040 nm femtosecond(fs) laser, the emission peaks at 680 nm of TB and 780 nm of nir775 excited by FRET were obtained. We utilized PSMA@TB/nir775 NPs as fluorescent contrast agents for two-photon excited nir microscopic imaging, and good nir imaging effect of mouse brain vasculature was obtained with the imaging depth of about 150 μm. The FRET strategy by coencapsulating AIE molecule and nir dye will be helpful in preparing more narrow emission nir probes for deep-tissue biological imaging.

关键词： nir emission AIE FRET Two-photon imaging Amphiphilic polymer

Integrating nir light photocage enables in vivo dual-channel tracking of drug release

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Science China Chemistry 2018年第11期61卷 1347-1348页

作者： Thorfinnur Gunnlaugsson School of Chemistry and Trinity Biomedical Sciences Institute (TBSI) Trinity College Dublin The University of Dublin

On-demand drug release at the right place and time becomes a central challenge in disease diagnosis and therapy. Light is a uniquely powerful tool to manipulate a biological process in space or time. Light-triggered drug delivery systems （DDSs） have proven to be an effective strategy for improving therapeutics. These caged prodrugs are functional lightsensitive probes that make the drug in an inactive form by covalent conjugation. Light irradiation liberates the caged drugs, permitting facile control intact and activate prodrugs in soace and time. It is limited, however.

关键词： vivo 版本 nir 集成追踪隧道用药疾病诊断

Construction of nir luminescent nanoscale lanthanide complexes with new flexible Schiff base ligands

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Journal of Rare Earths 2020年第2期38卷 143-147页

作者： Bichen Yuan Junbin Tao Fei Wang Chaoqun Zhu Min Li Xiaoping Yang Zhejiang Key Laboratory of Carbon Materials College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Four mono-and bi-nuclear lanthanide complexes [LnL1(No3)(H2O)DMF](Ln=Nd(1) and Yb(2)) and[Ln2(L2)2(OAc)2](Ln=Nd(3) and Yb(4)) were synthesized by using two new Schiff base ligands with long(CH2)2 NH(CH2)2 *** lengths of the Schiff base ligands are about 1.8 *** bi-nuclear lanthanide complexes 3 and 4 have nanoscale structures with sizes of approximately 0.7 nm×1.1 nm×1.6 *** 3,the molar ratio of Nd:Br:O obtained by the energy dispersive X-ray spectroscopy analysis is in agreement with the crystal *** chromogenic Schiff base ligands in1-4 can efficiently transfer energy to lanthanide ions,thus,these complexes exhibit the typical nir luminescence of lanthanide ***,3 and 4 have higher nir emission quantum yields(Φem)than 1 and 2,respectively.

关键词： Construction Schiff base ligands Lanthanide complexes Nanoscale structures nir luminescence Rare earths

Applying singular value decomposition technique for quantifying the insects in commercial Thai Hommali Rice from nir Spectrum

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Journal of Innovative Optical Health Sciences 2017年第2期10卷 93-104页

作者： Puttinun Jarruwat Prasan Choomjaihan Department of Agricultural Engineering Faculty of Engineering King Mongkut's Institute of Technology Ladkrabang LadkrabangBangkokThailand10520

Insect infestation in rice stock is a significant issue in rice exporting business,resulting in the loss of product quality,nutrient as well as the economic ***,detecting the insect cont amination with the traditional sorting techniques were destructive,inaccurate,time consuming and unable to detect the internal insect *** study used near infrared(nir)spectroscopy for obtaining the absorbent spectra from the insect cont amination in two kinds of rice samples,Milled Hommali rice(MHR)and Brown Hommali rice(BHR).The mathematical methods of partial least squares(PLSs)regression and singular value de-composition(SVD)were employed to construct the predicting *** statistical analysis results,R,RMSEP,RPD and bias,concluded that the predictive models from PLS for MHR and BHR were 0.95 and 0.90,0.014 and 0.019,4.79 and 3.11,as well as-0.007 and-0.008,respectively;while the statistical analysis results from SVD for MHR and BHR were 0.97 and 0.96,0.012 and 0.013,5.71 and 5.39,as well as-0.003 and 0.002,*** showed that SVD technique performed better than PLS technique which shows that using the advantage of SVD technique required less amounts of wave numbers for predicting and was possible to construct the low cost handheld equipment for detecting the insects in rice samples.

关键词： Insect rice nir SVD

Multi-organelle-targeting pH-dependent nir fluorescent probe for lysosomal viscosity

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Chinese Chemical Letters 2023年第3期34卷 378-382页

作者： Huili Wang Yishuo Sun Xuemei Lin Wei Feng Zhanxian Li Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences&Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China

The normal operation of lysosome, mitochondria, Golgi apparatus and endoplasmic reticulum plays a significant role in maintaining cell homeostasis. Reflecting the state and function of lysosomes, viscosity is a pivotal parameter to assess the stability of microenvironment. Herein, based on TICT mechanism,a new nir pH-dependent fluorescent probe DCIC with push-pull electronic moiety was synthesized to identify the lysosomes viscosity. In viscous media, DCIC was highly sensitive to viscosity, fluorescence intensity increased by 180 times as viscosity increased from 1.0 cp to 438.4 cp. In addition, DCIC have high localization ability for lysosome, mitochondria, Golgi apparatus, and endoplasmic reticulum and can monitor lysosomal viscosity fluctuations with laser confocal microscopy.

关键词： nir Lysosomal viscosity PH-dependent Multi-organelle localization

Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission nir spectroscopy

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 547-558页

作者： Elisabeth Peeters Ana Filipa Tavares da Silva Maunu Toiviainen Jeroen Van Renterghem Jurgen Vercruysse Mikko Juuti Joao Almeida Lopes Thomas De Beer Chris Vervaet Jean-Paul Remon Laboratory of Pharmaceutical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium Laboratory of Pharmaceutical Process Analytical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium REQUIMTE Department of Chemical SciencesUniversity of PortoRua de Jorge Viterbo Ferreira2284050-313PortoPortugal VTT Technical Research Centre of Finland Optical Measurement TechnologiesKaitoväylä190570 OuluFinland

This study investigated whether Raman and Near Infrared(nir) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares(PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn’t be established. Principal component analysis(PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression(MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.

关键词： Continuous production PAT Granulation Tableting nir Raman

Hyperbranched polylysine:Synthesis,mechanism and preparation for nir-absorbing gold nanoparticles

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Chinese Chemical Letters 2019年第7期30卷 1428-1431页

作者： Yiying Ge Pan Li Yanfei Guan Chang-Ming Dong School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal Aging Shanghai Jiao Tong University

The ring-opening polymerization (ROP) of N-(tetrafluoroboran ammonium)-L-lysine-N-carboxyanhydride (NH3BF4-Lys NCA) was initiated by triethylamine to prepare hyperbranched polylysine (HPlys) fluoroborate with narrow polydispersity at a low temperature. Both mass spectroscopy analysis and DFT computation evidenced that the resultant cyclic dimer mainly initiated ROP as a secondary species according to normal amine mechanism. The hyperbranched polylysine in aqueous solution existed in a unimolecular state at low concentrations, but transformed into spherical micellar aggregates at a high concentration of 5 mg/mL, as characterized by dynamic laser scattering and transmission electron microscopy. By utilizing multivalent coordination interactions between hyperbranched polylysine and gold, the plasmonic gold nanoparticles (HPlys@Au NPs) were successfully prepared in aqueous solution, which elevated the solution by 23.1℃ upon 5 min of nir laser irradiation (808 nm, 2 W/cm2).

关键词： Hyperbranched polylysine NCA ROP nir Gold nanoparticles

LapRLSR for nir spectral modeling and its application to online monitoring of the column separation of Salvianolate

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Chinese Chemical Letters 2007年第7期18卷 852-856页

作者： Hui Hua Yang Feng Qin Qiong Lin Liang Yong Wang Yi Ming Wang Guo An Lu Analysis Center Tsinghua University Beijing 100084 China College of Computer Science and Control Guilin University of Electronic Technology Guilin 541004 China Modern Engineering Center for Traditional Chinese Medicine School of Pharmacy East China University of Science and Technology Shanghai 200237 China

A novel near infrared （nir） modeling method-Laplacian regularized least squares regression （LapRLSR） was presented,which can take the advantage of many unlabeled spectra to promote the prediction performance of the model even if there are only few calibration samples. Using LapRLSR modeling, nir spectral analysis was applied to the online monitoring of the concentration of salvia acid B in the column separation of Salvianolate. The results demonstrated that LapRLSR outperformed partial least squares （PLS） significantly, and nir online analysis was applicable.

关键词： Laplacian regularized least squares regression (LapRLSR) PLS nir Salvianolate

Visualizing deeper into the body with a nir-Ⅱ small-molecule fluorophore

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Science China Chemistry 2016年第2期59卷 203-204页

作者： Weihong Zhu Shanghai Key Laboratory of Functional Materials Chemistry Institute of Fine Chemicals East China University of Science and Technology

Fluorescence imaging in the near-infrared（nir）window（750-900 nm）is one of the most popular work modes in biomedical sciences and clinical procedures for visualization of cells and tissues.

关键词：近红外可视化分子荧光荧光成像生物医学 nir

Determination of Vitamins B2,B3,B6 and B7 in Corn Steep Liquor by nir and PLSR

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Transactions of Tianjin University 2012年第5期18卷 372-377页

作者：肖雪侯媛媛杜军孙丹白钢罗国安 College of Pharmacy Nankai University Department of Chemistry Tsinghua University College of Life Science Nankai University China Biotech Fermentation Industry Association

Corn steep liquor(CSL) is an important raw material that has high nutritional value and serves as a nitrogen *** in CSL is especially of great importance to *** order to develop a fast,versatile,cheap,and environmentally safe analytical method for quantifying vitamins B2(VB2),B3(VB3),B6(VB6) and B7(VB7) in CSL,the near-infrared spectroscopy(nir) measurements of 66 samples(22 batches) of CSL were analyzed by partial least-square regression(PLSR).Multivariate models developed in the nir regions showed good predictive abilities for VB2,VB3,VB6 and *** confirmed the probability of the multivariate spectroscopic approach as a replacement for expensive and time-consuming conventional chemical methods.

关键词： corn steep liquor nir riboflavin nicotinic acid pyridoxine biotin multivariate calibration PLSR